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- W4313644792 endingPage "122589" @default.
- W4313644792 startingPage "122589" @default.
- W4313644792 abstract "Myocardial ischaemia is one of the leading dead causes worldwide. Although animal experiments have historically provided a wealth of information, animal models are time and money consuming, and they usually miss typical human patient's characteristics associated with ischemia prevalence, including aging and comorbidities. Generating reliable in vitro models that recapitulate the human cardiac microenvironment during an ischaemic event can boost the development of new drugs and therapeutic strategies, as well as our understanding of the underlying cellular and molecular events, helping the optimization of therapeutic approaches prior to animal and clinical testing. Although several culture systems have emerged for the recreation of cardiac physiology, mimicking the features of an ischaemic heart tissue in vitro is challenging and certain aspects of the disease process remain poorly addressed. Here, current in vitro cardiac culture systems used for modelling cardiac ischaemia, from self-aggregated organoids to scaffold-based constructs and heart-on-chip platforms are described. The advantages of these models to recreate ischaemic hallmarks such as oxygen gradients, pathological alterations of mechanical strength or fibrotic responses are highlighted. The new models represent a step forward to be considered, but unfortunately, we are far away from recapitulating all complexity of the clinical situations." @default.
- W4313644792 created "2023-01-07" @default.
- W4313644792 creator A5000843814 @default.
- W4313644792 creator A5033086178 @default.
- W4313644792 creator A5050029035 @default.
- W4313644792 creator A5076380047 @default.
- W4313644792 creator A5081849853 @default.
- W4313644792 creator A5087575355 @default.
- W4313644792 date "2023-02-01" @default.
- W4313644792 modified "2023-09-30" @default.
- W4313644792 title "Current approaches for the recreation of cardiac ischaemic environment in vitro" @default.
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