Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313644805> ?p ?o ?g. }
- W4313644805 endingPage "104548" @default.
- W4313644805 startingPage "104548" @default.
- W4313644805 abstract "Protein aggregation and associated amyloid formation is linked with several harmful human pathophysiologies including Alzheimer's, Parkinson's, and cerebrovascular diseases. A potential approach for modulating and exploring amyloid fibrillization is the control of protein self-assembly. Herein, anti-aggregation effects of salidroside, its influence on the kinetics of amyloid fibrillization of Aβ1-42 peptide and its cytotoxicity against cerebrovascular endothelial cells (bEnd.3) were assessed by using a wide range of spectroscopic and cellular techniques. The present outcome of Thioflavin T (ThT) and 8-anilino-1-naphthalenesulfonic acid (ANS) fluorescence, Congo red (CR), and circular dichroism (CD) analyses indicated that salidroside potentially inhibits protein fibril formation. The cellular studies inferred that salidroside protects bEnd.3 cells against Aβ1-42 oligomers -triggered cytotoxicity through modulation of oxidative stress [reactive oxygen species (ROS), superoxide dismutase (SOD) and catalase (CAT) activities] and apoptosis (caspase-3 activity). Therefore, the data signifies the role of salidroside as a promising small molecule in inhibiting Aβ1-42 aggregation and associated cerebrovascular endothelial cell toxicity. Hence, salidroside can serve as a potential inhibitor in the therapeutic advancement to combat cerebrovascular diseases." @default.
- W4313644805 created "2023-01-07" @default.
- W4313644805 creator A5017188043 @default.
- W4313644805 creator A5028179790 @default.
- W4313644805 creator A5030574650 @default.
- W4313644805 creator A5035302440 @default.
- W4313644805 creator A5043424443 @default.
- W4313644805 creator A5052147941 @default.
- W4313644805 creator A5066849610 @default.
- W4313644805 creator A5090802872 @default.
- W4313644805 date "2023-04-01" @default.
- W4313644805 modified "2023-09-25" @default.
- W4313644805 title "An in vitro study on probable inhibition of cerebrovascular disease by salidroside as a potent small molecule against induction of protein amyloid fibrils and cytotoxicity" @default.
- W4313644805 cites W1525374648 @default.
- W4313644805 cites W1897351868 @default.
- W4313644805 cites W1971286661 @default.
- W4313644805 cites W1971351365 @default.
- W4313644805 cites W1971800836 @default.
- W4313644805 cites W1971960647 @default.
- W4313644805 cites W1976115853 @default.
- W4313644805 cites W1983469460 @default.
- W4313644805 cites W1987066756 @default.
- W4313644805 cites W2004217814 @default.
- W4313644805 cites W2005813746 @default.
- W4313644805 cites W2006035554 @default.
- W4313644805 cites W2014600874 @default.
- W4313644805 cites W2026218920 @default.
- W4313644805 cites W2027001486 @default.
- W4313644805 cites W2032210346 @default.
- W4313644805 cites W2039169280 @default.
- W4313644805 cites W2047908784 @default.
- W4313644805 cites W2047909392 @default.
- W4313644805 cites W2052749821 @default.
- W4313644805 cites W2058963617 @default.
- W4313644805 cites W2062071602 @default.
- W4313644805 cites W2066835973 @default.
- W4313644805 cites W2073566962 @default.
- W4313644805 cites W2079275694 @default.
- W4313644805 cites W2080848479 @default.
- W4313644805 cites W2082955344 @default.
- W4313644805 cites W2084484659 @default.
- W4313644805 cites W2093274908 @default.
- W4313644805 cites W2100764155 @default.
- W4313644805 cites W2103859034 @default.
- W4313644805 cites W2106695363 @default.
- W4313644805 cites W2123915283 @default.
- W4313644805 cites W2157902443 @default.
- W4313644805 cites W2332681686 @default.
- W4313644805 cites W2401053207 @default.
- W4313644805 cites W2486642379 @default.
- W4313644805 cites W2552743040 @default.
- W4313644805 cites W2604840146 @default.
- W4313644805 cites W2612326057 @default.
- W4313644805 cites W2613251895 @default.
- W4313644805 cites W2614053601 @default.
- W4313644805 cites W2616724130 @default.
- W4313644805 cites W2761487449 @default.
- W4313644805 cites W2769369612 @default.
- W4313644805 cites W2780452922 @default.
- W4313644805 cites W2791074822 @default.
- W4313644805 cites W2890224686 @default.
- W4313644805 cites W2944931332 @default.
- W4313644805 cites W2979286945 @default.
- W4313644805 cites W3047014653 @default.
- W4313644805 cites W3092964313 @default.
- W4313644805 cites W3124348440 @default.
- W4313644805 cites W4322703192 @default.
- W4313644805 cites W834156084 @default.
- W4313644805 doi "https://doi.org/10.1016/j.arabjc.2023.104548" @default.
- W4313644805 hasPublicationYear "2023" @default.
- W4313644805 type Work @default.
- W4313644805 citedByCount "0" @default.
- W4313644805 crossrefType "journal-article" @default.
- W4313644805 hasAuthorship W4313644805A5017188043 @default.
- W4313644805 hasAuthorship W4313644805A5028179790 @default.
- W4313644805 hasAuthorship W4313644805A5030574650 @default.
- W4313644805 hasAuthorship W4313644805A5035302440 @default.
- W4313644805 hasAuthorship W4313644805A5043424443 @default.
- W4313644805 hasAuthorship W4313644805A5052147941 @default.
- W4313644805 hasAuthorship W4313644805A5066849610 @default.
- W4313644805 hasAuthorship W4313644805A5090802872 @default.
- W4313644805 hasBestOaLocation W43136448051 @default.
- W4313644805 hasConcept C109316439 @default.
- W4313644805 hasConcept C12554922 @default.
- W4313644805 hasConcept C136238340 @default.
- W4313644805 hasConcept C142724271 @default.
- W4313644805 hasConcept C179104552 @default.
- W4313644805 hasConcept C185592680 @default.
- W4313644805 hasConcept C202751555 @default.
- W4313644805 hasConcept C27523624 @default.
- W4313644805 hasConcept C2775838275 @default.
- W4313644805 hasConcept C2776151105 @default.
- W4313644805 hasConcept C2777633098 @default.
- W4313644805 hasConcept C2778896982 @default.
- W4313644805 hasConcept C2779134260 @default.
- W4313644805 hasConcept C2779526882 @default.
- W4313644805 hasConcept C43617362 @default.
- W4313644805 hasConcept C48349386 @default.