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• W4313644908 abstract "In the olfactory bulb (OB), a large population of axon-less inhibitory interneurons, the granule cells (GCs), coordinate network activity and tune the output of principal neurons, the mitral and tufted cells (MCs), through dendrodendritic interactions. Furthermore, GCs undergo neurogenesis throughout life, providing a source of plasticity to the neural network of the OB. The function and integration of GCs in the OB are regulated by several afferent neuromodulatory signals, including noradrenaline (NA), a state-dependent neuromodulator that plays a crucial role in the regulation of cortical function and task-specific decision processes. However, the mechanisms by which NA regulates GC function are not fully understood. Here, we show that NA modulates hyperpolarization-activated currents (I h ) via the activation of α 2 -adrenergic receptors (ARs) in adult-born GCs (abGCs), thus directly acting on channels that play essential roles in regulating neuronal excitability and network oscillations in the brain. This modulation affects the dendrodendritic output of GCs leading to an enhancement of lateral inhibition onto the MCs. Furthermore, we show that NA modulates subthreshold resonance in GCs, which could affect the temporal integration of abGCs. Together, these results provide a novel mechanism by which a state-dependent neuromodulator acting on I h can regulate GC function in the OB." @default.
• W4313644908 created "2023-01-07" @default.
• W4313644908 creator A5007483638 @default.
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• W4313644908 creator A5082035213 @default.
• W4313644908 date "2023-01-06" @default.
• W4313644908 modified "2023-09-26" @default.
• W4313644908 title "α2-Adrenergic modulation of Ih in adult-born granule cells in the olfactory bulb" @default.
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• W4313644908 doi "https://doi.org/10.3389/fncel.2022.1055569" @default.
• W4313644908 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36687519" @default.
• W4313644908 hasPublicationYear "2023" @default.
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