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• W4313644992 endingPage "111605" @default.
• W4313644992 startingPage "111605" @default.
• W4313644992 abstract "The advancement in additive manufacturing in recent years opened a new era for bone reconstruction methods, allowing for the design of customized implants that perfectly match clinical needs. This challenge is even more prominent in critical-sized bone defects, where the bone cannot heal independently. Here we present a novel workflow for such cases. First, a multidisciplinary team conducted the surgical plan, including the design of an intraoperative patient-specific instrument. Then, a Ti-6Al-4V implant was created to exactly fit the resected tumor's bone gap. An ambitious bone regenerative approach was taken in designing the implants with a porous-lattice body acting as a scaffold for new bone formation, reinforced with standard orthopedic instruments for adequate mechanical support. To prevent future failure of the implant, a finite element analysis was used to evaluate stress distribution simulation according to the multi-axis forces and moments applied on the bone during walking. Our results demonstrate the potential for Ti-6Al-4V implants to become the best practice for reconstructing significant bone defects. This proof-of-concept may enhance clinical care and catalyze new frontiers in patient-specific medicine. To the best of our knowledge, this is the first study to describe in detail the design and fabrication of this method." @default.
• W4313644992 created "2023-01-07" @default.
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• W4313644992 date "2023-02-01" @default.
• W4313644992 modified "2023-10-18" @default.
• W4313644992 title "Patient-specific Ti-6Al-4V lattice implants for critical-sized load-bearing bone defects reconstruction" @default.
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• W4313644992 doi "https://doi.org/10.1016/j.matdes.2023.111605" @default.
• W4313644992 hasPublicationYear "2023" @default.
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