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- W4313645100 abstract "Dendritic and monocytic cells co-operate to initiate and shape adaptive immune responses in secondary lymphoid tissue. The complexity of this system is poorly understood, also because of the high phenotypic and functional plasticity of monocytic cells. We have sequenced mononuclear phagocytes in mesenteric lymph nodes (LN) of three adult cows at the single-cell level, revealing ten dendritic-cell (DC) clusters and seven monocyte/macrophage clusters with clearly distinct transcriptomic profiles. Among DC, we defined LN-resident subsets and their progenitors, as well as subsets of highly activated migratory DC differing in transcript levels for T-cell attracting chemokines. Our analyses also revealed a potential differentiation path for cDC2, resulting in a cluster of inflammatory cDC2 with close transcriptional similarity to putative DC3 and monocyte-derived DC. Monocytes and macrophages displayed sub-clustering mainly driven by pro- or anti-inflammatory expression signatures, including a small cluster of cycling, presumably self-renewing, macrophages. With this transcriptomic snapshot of LN-derived mononuclear phagocytes, we reveal functional properties and differentiation trajectories in a command center of immunity, and identify elements that are conserved across species." @default.
- W4313645100 created "2023-01-07" @default.
- W4313645100 creator A5026079974 @default.
- W4313645100 creator A5046700079 @default.
- W4313645100 creator A5058027953 @default.
- W4313645100 creator A5084203689 @default.
- W4313645100 creator A5028583970 @default.
- W4313645100 date "2023-01-06" @default.
- W4313645100 modified "2023-10-14" @default.
- W4313645100 title "Single-cell transcriptomics reveals striking heterogeneity and functional organization of dendritic and monocytic cells in the bovine mesenteric lymph node" @default.
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