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- W4313646589 abstract "Abstract Trehalose is the nonreducing disaccharide of glucose, evolutionarily conserved in invertebrates. The living skin equivalent (LSE) is an organotypic coculture containing keratinocytes cultivated on fibroblast-populated dermal substitutes. We demonstrated that human primary fibroblasts treated with highly concentrated trehalose promote significantly extensive spread of the epidermal layer of LSE without any deleterious effects. The RNA-seq analysis of trehalose-treated 2D and 3D fibroblasts at early time points revealed the involvement of the CDKN1A pathway, the knockdown of which significantly suppressed the upregulation of DPT , ANGPT2 , VEGFA , EREG , and FGF2 . The trehalose-treated fibroblasts were positive for senescence-associated β-galactosidase. Finally, transplantation of the dermal substitute with trehalose-treated fibroblasts accelerated wound closure and increased capillary formation significantly in the experimental mouse wounds in vivo, which was canceled by the CDKN1A knockdown. These data indicate that high-concentration trehalose can induce the senescence-like state in fibroblasts via CDKN1A/p21, which may be therapeutically useful for optimal wound repair." @default.
- W4313646589 created "2023-01-07" @default.
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- W4313646589 date "2023-01-06" @default.
- W4313646589 modified "2023-10-18" @default.
- W4313646589 title "Highly concentrated trehalose induces prohealing senescence-like state in fibroblasts via CDKN1A/p21" @default.
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- W4313646589 doi "https://doi.org/10.1038/s42003-022-04408-3" @default.
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