FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313646816> ?p ?o ?g. }

• W4313646816 endingPage "1627" @default.
• W4313646816 startingPage "1613" @default.
• W4313646816 abstract "Abstract Background Numerous studies have shown that various products of Citrus sinensis , for example, crude extracts, essential oil, and purified components, possess anti‐acne properties. However, the development of chlorogenic acid‐functionalized silver nanoparticles of C. sinensis in gel matrix aiding QbD design has not been evaluated for acne treatment. Aim In this study, we have developed chlorogenic acid‐functionalized silver nanoparticles of C. sinensis in a gel matrix employing a QbD approach for acne treatment. Material and Method Citrus sinensis extract‐loaded silver nanoparticles were functionalized with chlorogenic acid, which acted as a bio‐reducing agent and further improved anti‐acne properties. The developed formulation was optimized via Box‐Behnken Design. The formulation morphology was evaluated by transmission electron microscopy (TEM). The release profile of C. sinensis extract formulation was assessed by an in vitro release study and confocal laser scanning microscopy (CLSM). Moreover, the characterization study of the gel was performed that included an evaluation of the extrudability and spreadability of the developed gel. Furthermore, the anti‐oxidant efficacy of AgN‐CA formulation was validated using the DPPH test. Results The results showed a particle size of 71.78 nm, a polydispersity index of 0.297, a zeta potential of −36.12 mV, and an entrapment efficiency of 79.42% ± 6.79%. The results also indicated a uniform particle size. The release profile of C. sinensis extract revealed that 73.95% of the drug was released, whereas CLSM pictures of mice skin evidently demonstrated that the rhodamine B‐treated AgN‐CA gel penetrated much more extensively in comparison to the control. Furthermore, the anti‐oxidant efficacy of AgN‐CA formulation was validated using the DPPH test. Moreover, the characterization study of the developed gel, including its extrudability and spreadability, was found to be 16.02 ± 3.21 g and 30.73 ± 5.94 g cm/s, respectively. Also, texture analysis findings revealed that AgN‐CA gel had firmness, consistency, cohesiveness, and viscosity index of 159.69 g, 634.95 g s, −116.33 g, and −501.80 g s, respectively, indicating that the AgN‐CA gel was stable. Conclusion The current study showed that AgN‐CA is an effective drug carrier system for the topical administration of C. sinensis extract for the treatment of acne." @default.
• W4313646816 created "2023-01-07" @default.
• W4313646816 creator A5002913214 @default.
• W4313646816 creator A5009890325 @default.
• W4313646816 creator A5078733837 @default.
• W4313646816 creator A5080246176 @default.
• W4313646816 date "2023-01-06" @default.
• W4313646816 modified "2023-10-18" @default.
• W4313646816 title "Microwave‐assisted and chemically tailored chlorogenic acid‐functionalized silver nanoparticles of <i>Citrus sinensis</i> in gel matrix aiding QbD design for the treatment of acne" @default.
• W4313646816 cites W1970642338 @default.
• W4313646816 cites W2013645301 @default.
• W4313646816 cites W2022371085 @default.
• W4313646816 cites W2026948599 @default.
• W4313646816 cites W2035287530 @default.
• W4313646816 cites W2069574681 @default.
• W4313646816 cites W2083056135 @default.
• W4313646816 cites W2168427420 @default.
• W4313646816 cites W2321509975 @default.
• W4313646816 cites W2398308946 @default.
• W4313646816 cites W2412497043 @default.
• W4313646816 cites W2536586726 @default.
• W4313646816 cites W2725644489 @default.
• W4313646816 cites W2886632756 @default.
• W4313646816 cites W3006242464 @default.
• W4313646816 cites W3083220852 @default.
• W4313646816 cites W3084849923 @default.
• W4313646816 cites W3101837835 @default.
• W4313646816 cites W3118898368 @default.
• W4313646816 cites W3122026632 @default.
• W4313646816 cites W3174778648 @default.
• W4313646816 cites W4229443482 @default.
• W4313646816 doi "https://doi.org/10.1111/jocd.15611" @default.
• W4313646816 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36606381" @default.
• W4313646816 hasPublicationYear "2023" @default.
• W4313646816 type Work @default.
• W4313646816 citedByCount "8" @default.
• W4313646816 countsByYear W43136468162023 @default.
• W4313646816 crossrefType "journal-article" @default.
• W4313646816 hasAuthorship W4313646816A5002913214 @default.
• W4313646816 hasAuthorship W4313646816A5009890325 @default.
• W4313646816 hasAuthorship W4313646816A5078733837 @default.
• W4313646816 hasAuthorship W4313646816A5080246176 @default.
• W4313646816 hasBestOaLocation W43136468161 @default.
• W4313646816 hasConcept C106487976 @default.
• W4313646816 hasConcept C11432220 @default.
• W4313646816 hasConcept C147789679 @default.
• W4313646816 hasConcept C155672457 @default.
• W4313646816 hasConcept C171250308 @default.
• W4313646816 hasConcept C178790620 @default.
• W4313646816 hasConcept C185592680 @default.
• W4313646816 hasConcept C187530423 @default.
• W4313646816 hasConcept C188027245 @default.
• W4313646816 hasConcept C192562407 @default.
• W4313646816 hasConcept C2778004101 @default.
• W4313646816 hasConcept C2780117898 @default.
• W4313646816 hasConcept C2781401929 @default.
• W4313646816 hasConcept C31499863 @default.
• W4313646816 hasConcept C43617362 @default.
• W4313646816 hasConcept C86181022 @default.
• W4313646816 hasConceptScore W4313646816C106487976 @default.
• W4313646816 hasConceptScore W4313646816C11432220 @default.
• W4313646816 hasConceptScore W4313646816C147789679 @default.
• W4313646816 hasConceptScore W4313646816C155672457 @default.
• W4313646816 hasConceptScore W4313646816C171250308 @default.
• W4313646816 hasConceptScore W4313646816C178790620 @default.
• W4313646816 hasConceptScore W4313646816C185592680 @default.
• W4313646816 hasConceptScore W4313646816C187530423 @default.
• W4313646816 hasConceptScore W4313646816C188027245 @default.
• W4313646816 hasConceptScore W4313646816C192562407 @default.
• W4313646816 hasConceptScore W4313646816C2778004101 @default.
• W4313646816 hasConceptScore W4313646816C2780117898 @default.
• W4313646816 hasConceptScore W4313646816C2781401929 @default.
• W4313646816 hasConceptScore W4313646816C31499863 @default.
• W4313646816 hasConceptScore W4313646816C43617362 @default.
• W4313646816 hasConceptScore W4313646816C86181022 @default.
• W4313646816 hasIssue "5" @default.
• W4313646816 hasLocation W43136468161 @default.
• W4313646816 hasLocation W43136468162 @default.
• W4313646816 hasOpenAccess W4313646816 @default.
• W4313646816 hasPrimaryLocation W43136468161 @default.
• W4313646816 hasRelatedWork W1971645600 @default.
• W4313646816 hasRelatedWork W1997967820 @default.
• W4313646816 hasRelatedWork W2140907237 @default.
• W4313646816 hasRelatedWork W2203584037 @default.
• W4313646816 hasRelatedWork W2352333521 @default.
• W4313646816 hasRelatedWork W3013981841 @default.
• W4313646816 hasRelatedWork W3097648928 @default.
• W4313646816 hasRelatedWork W3191972723 @default.
• W4313646816 hasRelatedWork W3200438866 @default.
• W4313646816 hasRelatedWork W4382811226 @default.
• W4313646816 hasVolume "22" @default.
• W4313646816 isParatext "false" @default.
• W4313646816 isRetracted "false" @default.
• W4313646816 workType "article" @default.