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- W4313646893 startingPage "233" @default.
- W4313646893 abstract "Rapid responses to changes within subcellular compartments of highly polarized cells, such as neuron axons, depend on local translation and post-transcriptional regulation. The mechanism by which microRNAs (miRNAs) regulate this process is not fully understood. Here, using live cell imaging and RNA sequencing analysis, we demonstrated how miRNAs can differentially control hundreds of transcripts at the subcellular level. We demonstrated that the seed match length of the miRNA target-sequence regulates both mRNA stability and protein translation rates. While longer seed matches have an increased inhibitory effect, transcriptome analysis did not reveal differences in seed match length between axonal and somata mRNAs of motor neurons. However, mRNA variants with longer 3′UTR are enriched in axons and contain multiple repeats of specific miRNA target sequences. Finally, we demonstrated that the long 3′UTR mRNA variant of the motor protein Kif5b is enriched explicitly in motor neuron axons and contains multiple sequence repeats for binding miR-129-5p. This subsequently results in the differential post-transcriptional regulation of kif5b and its synthesis in axons. Thus, we suggest that the number of miRNA binding sites at the 3′UTR of the mRNA, rather than the miRNA seed match length, regulates the axonal transcriptome." @default.
- W4313646893 created "2023-01-07" @default.
- W4313646893 creator A5008264999 @default.
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- W4313646893 creator A5077490908 @default.
- W4313646893 date "2023-01-06" @default.
- W4313646893 modified "2023-10-01" @default.
- W4313646893 title "Multiple Copies of microRNA Binding Sites in Long 3′UTR Variants Regulate Axonal Translation" @default.
- W4313646893 cites W1968683040 @default.
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- W4313646893 cites W1986028587 @default.
- W4313646893 cites W1986172894 @default.
- W4313646893 cites W1993799748 @default.
- W4313646893 cites W1997231473 @default.
- W4313646893 cites W1997759588 @default.
- W4313646893 cites W2005564932 @default.
- W4313646893 cites W2018368761 @default.
- W4313646893 cites W2018384224 @default.
- W4313646893 cites W2026570544 @default.
- W4313646893 cites W2030373893 @default.
- W4313646893 cites W2036065307 @default.
- W4313646893 cites W2036950925 @default.
- W4313646893 cites W2050869737 @default.
- W4313646893 cites W2059357290 @default.
- W4313646893 cites W2060737779 @default.
- W4313646893 cites W2062890651 @default.
- W4313646893 cites W2068962163 @default.
- W4313646893 cites W2070571588 @default.
- W4313646893 cites W2072977612 @default.
- W4313646893 cites W2073256947 @default.
- W4313646893 cites W2077921825 @default.
- W4313646893 cites W2079030743 @default.
- W4313646893 cites W2081663509 @default.
- W4313646893 cites W2083381199 @default.
- W4313646893 cites W2088930981 @default.
- W4313646893 cites W2102883851 @default.
- W4313646893 cites W2106117608 @default.
- W4313646893 cites W2109936556 @default.
- W4313646893 cites W2124239182 @default.
- W4313646893 cites W2127122830 @default.
- W4313646893 cites W2131642921 @default.
- W4313646893 cites W2132798017 @default.
- W4313646893 cites W2134223330 @default.
- W4313646893 cites W2134526812 @default.
- W4313646893 cites W2134629862 @default.
- W4313646893 cites W2139622708 @default.
- W4313646893 cites W2145021085 @default.
- W4313646893 cites W2157157037 @default.
- W4313646893 cites W2169456326 @default.
- W4313646893 cites W2171108941 @default.
- W4313646893 cites W2171376759 @default.
- W4313646893 cites W2179438025 @default.
- W4313646893 cites W2180388440 @default.
- W4313646893 cites W2203221155 @default.
- W4313646893 cites W2500444210 @default.
- W4313646893 cites W2519208414 @default.
- W4313646893 cites W2544684176 @default.
- W4313646893 cites W2560541836 @default.
- W4313646893 cites W2595733686 @default.
- W4313646893 cites W2606391892 @default.
- W4313646893 cites W2725805506 @default.
- W4313646893 cites W2789909579 @default.
- W4313646893 cites W2790053519 @default.
- W4313646893 cites W2791640295 @default.
- W4313646893 cites W2798058472 @default.
- W4313646893 cites W2890638884 @default.
- W4313646893 cites W2891058115 @default.
- W4313646893 cites W2895793011 @default.
- W4313646893 cites W2899851803 @default.
- W4313646893 cites W2906533249 @default.
- W4313646893 cites W2907315139 @default.
- W4313646893 cites W2907496349 @default.
- W4313646893 cites W2920007917 @default.
- W4313646893 cites W2945232783 @default.
- W4313646893 cites W2950985970 @default.
- W4313646893 cites W2951912016 @default.
- W4313646893 cites W3001462302 @default.
- W4313646893 cites W3018861406 @default.
- W4313646893 cites W3024244753 @default.
- W4313646893 cites W3099613440 @default.
- W4313646893 cites W3114362143 @default.
- W4313646893 cites W3131024606 @default.
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- W4313646893 doi "https://doi.org/10.3390/cells12020233" @default.
- W4313646893 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36672174" @default.
- W4313646893 hasPublicationYear "2023" @default.
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