Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313646940> ?p ?o ?g. }
- W4313646940 endingPage "830" @default.
- W4313646940 startingPage "817" @default.
- W4313646940 abstract "Clopidogrel is the only antiplatelet agent whose activity is significantly affected by CYP2C19 polymorphism.This review has summarized the available evidence on the clinically significant association between CYP2C19 polymorphism and clopidogrel-based therapy; reviewed the current recommendations for clinical use of CYP2C19 genotype test results in patients on clopidogrel treatment; and discussed possible pitfalls of routine application, and future perspectives of antiplatelets pharmacogenetics.The available body of evidence, reflected in several meta-analyses and high-quality clinical practice guidelines, shows that the presence of CYP2C19 LOF alleles, especially CYP2C19*2, correlates with impaired activation of clopidogrel and variable platelet inhibition, followed by minimal or no antiplatelet effect, and higher risk of treatment failure. In combination with other known risk factors, CYP2C19 genetic testing could be very valuable in predicting low clopidogrel efficacy. At the same time, it could be very successful in selecting patients who will most probably benefit from the clopidogrel-based therapy, thus decreasing the pool of those who might need more expensive and otherwise riskier antiplatelet alternatives." @default.
- W4313646940 created "2023-01-07" @default.
- W4313646940 creator A5006203968 @default.
- W4313646940 date "2022-12-02" @default.
- W4313646940 modified "2023-09-23" @default.
- W4313646940 title "Genotyping genetic variants of <i>CYP2C19</i> for precision antiplatelet dosing: state of the art and future perspectives" @default.
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