FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313647037> ?p ?o ?g. }

• W4313647037 endingPage "108" @default.
• W4313647037 startingPage "108" @default.
• W4313647037 abstract "Traumatic brain injury (TBI) is a serious global risk factor leading to the onset of cognitive impairment and neurodegenerative diseases. Cognitive and memory impairment following a TBI is associated with the dysregulation of cholinergic neurotransmission in the brains of subjects. The extent of memory impairment following a TBI is linked with the sex of the subject. This study aimed to identify the sex-dimorphic role of muscarinic cholinergic modulation in neurological functioning and episodic memory retrieval in a mouse model of TBI. Balb/c mice were divided into four groups of males and four groups of females (i.e., Sham, TBI, TBI + Scopolamine 1 mg/kg, and TBI + Donepezil 1 mg/kg). After training with the Morris water maze test and fear conditioning, all groups were subjected to brain injury (7.84 × 10-5 J impact force) except for the Sham mice. Following brain injury, scopolamine or donepezil was administered to the respective groups for 5 days. Acute scopolamine immediately after brain trauma showed a neuroprotective effect in the males only, while subchronic donepezil significantly impaired neurological functioning in both sexes. Subchronic scopolamine and donepezil treatment reversed the TBI-induced retrograde amnesia for spatial memory in male mice. Contextual fear memory retrieval was not affected by the TBI and treatments in both sexes. Thus, we concluded that the sex-dimorphic response of the muscarinic receptors in TBI-induced memory impairment depends on the type of memory. This study highlights the potential for therapeutic modalities in TBI subjects." @default.
• W4313647037 created "2023-01-07" @default.
• W4313647037 creator A5050832322 @default.
• W4313647037 creator A5091597392 @default.
• W4313647037 date "2023-01-06" @default.
• W4313647037 modified "2023-10-06" @default.
• W4313647037 title "Influence of Sex and Muscarinic Activity on Memory Retrieval in Mouse Model of Traumatic Brain Injury" @default.
• W4313647037 cites W1499271369 @default.
• W4313647037 cites W1510266002 @default.
• W4313647037 cites W1550447348 @default.
• W4313647037 cites W1913365550 @default.
• W4313647037 cites W1970991292 @default.
• W4313647037 cites W1985900925 @default.
• W4313647037 cites W1989990363 @default.
• W4313647037 cites W1993083632 @default.
• W4313647037 cites W2000057840 @default.
• W4313647037 cites W2002242287 @default.
• W4313647037 cites W2003397159 @default.
• W4313647037 cites W2009397486 @default.
• W4313647037 cites W2016456740 @default.
• W4313647037 cites W2017414318 @default.
• W4313647037 cites W2021978868 @default.
• W4313647037 cites W2024005713 @default.
• W4313647037 cites W2024325218 @default.
• W4313647037 cites W2034354239 @default.
• W4313647037 cites W2034607987 @default.
• W4313647037 cites W2034979448 @default.
• W4313647037 cites W2036264929 @default.
• W4313647037 cites W2043526429 @default.
• W4313647037 cites W2061629609 @default.
• W4313647037 cites W2068462003 @default.
• W4313647037 cites W2072974386 @default.
• W4313647037 cites W2081496525 @default.
• W4313647037 cites W2090902868 @default.
• W4313647037 cites W2092828502 @default.
• W4313647037 cites W2094880322 @default.
• W4313647037 cites W2101327029 @default.
• W4313647037 cites W2107307178 @default.
• W4313647037 cites W2120174717 @default.
• W4313647037 cites W2122431232 @default.
• W4313647037 cites W2146031912 @default.
• W4313647037 cites W2150281971 @default.
• W4313647037 cites W2162870648 @default.
• W4313647037 cites W2202636361 @default.
• W4313647037 cites W2339860423 @default.
• W4313647037 cites W2488854829 @default.
• W4313647037 cites W2530980501 @default.
• W4313647037 cites W2548629649 @default.
• W4313647037 cites W2611266680 @default.
• W4313647037 cites W2612711353 @default.
• W4313647037 cites W2804597648 @default.
• W4313647037 cites W2891380041 @default.
• W4313647037 cites W2893023710 @default.
• W4313647037 cites W3111137039 @default.
• W4313647037 cites W324583972 @default.
• W4313647037 cites W4206233669 @default.
• W4313647037 cites W9218748 @default.
• W4313647037 doi "https://doi.org/10.3390/brainsci13010108" @default.
• W4313647037 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36672089" @default.
• W4313647037 hasPublicationYear "2023" @default.
• W4313647037 type Work @default.
• W4313647037 citedByCount "1" @default.
• W4313647037 crossrefType "journal-article" @default.
• W4313647037 hasAuthorship W4313647037A5050832322 @default.
• W4313647037 hasAuthorship W4313647037A5091597392 @default.
• W4313647037 hasBestOaLocation W43136470371 @default.
• W4313647037 hasConcept C118552586 @default.
• W4313647037 hasConcept C126322002 @default.
• W4313647037 hasConcept C15744967 @default.
• W4313647037 hasConcept C169760540 @default.
• W4313647037 hasConcept C169900460 @default.
• W4313647037 hasConcept C170493617 @default.
• W4313647037 hasConcept C181199279 @default.
• W4313647037 hasConcept C185592680 @default.
• W4313647037 hasConcept C22885893 @default.
• W4313647037 hasConcept C2777544248 @default.
• W4313647037 hasConcept C2778615406 @default.
• W4313647037 hasConcept C2778816929 @default.
• W4313647037 hasConcept C2779134260 @default.
• W4313647037 hasConcept C2779483572 @default.
• W4313647037 hasConcept C2780904820 @default.
• W4313647037 hasConcept C2781017439 @default.
• W4313647037 hasConcept C3018842126 @default.
• W4313647037 hasConcept C33789571 @default.
• W4313647037 hasConcept C42219234 @default.
• W4313647037 hasConcept C44752575 @default.
• W4313647037 hasConcept C55493867 @default.
• W4313647037 hasConcept C71924100 @default.
• W4313647037 hasConceptScore W4313647037C118552586 @default.
• W4313647037 hasConceptScore W4313647037C126322002 @default.
• W4313647037 hasConceptScore W4313647037C15744967 @default.
• W4313647037 hasConceptScore W4313647037C169760540 @default.
• W4313647037 hasConceptScore W4313647037C169900460 @default.
• W4313647037 hasConceptScore W4313647037C170493617 @default.
• W4313647037 hasConceptScore W4313647037C181199279 @default.
• W4313647037 hasConceptScore W4313647037C185592680 @default.
• W4313647037 hasConceptScore W4313647037C22885893 @default.
• W4313647037 hasConceptScore W4313647037C2777544248 @default.

• next