Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313647412> ?p ?o ?g. }
- W4313647412 abstract "Abstract The self‐preservation and intelligent survival abilities of methicillin‐resistant Staphylococcus aureus (MRSA) result in the ineffective treatment of many antibiotics. Nano‐drug delivery systems have emerged as a new strategy to overcome MRSA infection. ZIF‐8 nanoparticles (ZIF‐8 NPs) exhibit good antibacterial activities, while its molecular mechanisms are largely elusive. In this study, the ZIF‐8 NPs are prepared using the room temperature solution reaction method. The values of minimum inhibitory concentration of ZIF‐8 NPs against Escherichia coli and MRSA isolates are 25 and 12.5 µg mL −1 , respectively. Transcriptome and metabonomic analyses reveal that ZIF‐8 NPs could trigger the inhibition of arginine biosynthesis pathway and the production of ROS, which lead to dysfunctional tricarboxylic acid cycle and disruption of cell membrane integrity, eventually killing MRSA isolates. Moreover, ZIF‐8 NPs show desirable treatment and repair effects on mice model of MRSA isolates wound infected‐model. The results, for the first time, reveal that the inhibition of arginine biosynthesis mediates the production of ROS and energy metabolism dysfunction contributes to the antibacterial ability of ZIF‐8 NPs against MRSA. This study offers a new insight into ZIF‐8 NPs combating MRSA isolates." @default.
- W4313647412 created "2023-01-07" @default.
- W4313647412 creator A5031456572 @default.
- W4313647412 creator A5034821623 @default.
- W4313647412 creator A5044344398 @default.
- W4313647412 creator A5065029077 @default.
- W4313647412 creator A5081244789 @default.
- W4313647412 creator A5086077764 @default.
- W4313647412 creator A5090815103 @default.
- W4313647412 date "2023-01-05" @default.
- W4313647412 modified "2023-10-16" @default.
- W4313647412 title "Zeolitic Imidazolate Framework‐8 Triggers the Inhibition of Arginine Biosynthesis to Combat Methicillin‐Resistant <i>Staphylococcus Aureus</i>" @default.
- W4313647412 cites W1876562917 @default.
- W4313647412 cites W1968604357 @default.
- W4313647412 cites W1998904566 @default.
- W4313647412 cites W2009806571 @default.
- W4313647412 cites W2009950427 @default.
- W4313647412 cites W2026551617 @default.
- W4313647412 cites W2033170435 @default.
- W4313647412 cites W2069799587 @default.
- W4313647412 cites W2075551106 @default.
- W4313647412 cites W2076795105 @default.
- W4313647412 cites W2080094023 @default.
- W4313647412 cites W2083467196 @default.
- W4313647412 cites W2103745493 @default.
- W4313647412 cites W2112896586 @default.
- W4313647412 cites W2114579765 @default.
- W4313647412 cites W2116141575 @default.
- W4313647412 cites W2120078902 @default.
- W4313647412 cites W2131589156 @default.
- W4313647412 cites W2141939342 @default.
- W4313647412 cites W2153292236 @default.
- W4313647412 cites W2163564255 @default.
- W4313647412 cites W2170371167 @default.
- W4313647412 cites W2291003829 @default.
- W4313647412 cites W2550538514 @default.
- W4313647412 cites W2574984917 @default.
- W4313647412 cites W2613655746 @default.
- W4313647412 cites W2768700845 @default.
- W4313647412 cites W2791687741 @default.
- W4313647412 cites W2801096440 @default.
- W4313647412 cites W2865240534 @default.
- W4313647412 cites W2888763868 @default.
- W4313647412 cites W2890107192 @default.
- W4313647412 cites W2892663892 @default.
- W4313647412 cites W2896255826 @default.
- W4313647412 cites W2908951387 @default.
- W4313647412 cites W2921279637 @default.
- W4313647412 cites W2942054658 @default.
- W4313647412 cites W2946353546 @default.
- W4313647412 cites W2978773783 @default.
- W4313647412 cites W2982226013 @default.
- W4313647412 cites W2985774332 @default.
- W4313647412 cites W2989863697 @default.
- W4313647412 cites W2994669467 @default.
- W4313647412 cites W2999937356 @default.
- W4313647412 cites W3000336454 @default.
- W4313647412 cites W3025734514 @default.
- W4313647412 cites W3048810707 @default.
- W4313647412 cites W3049430787 @default.
- W4313647412 cites W3093247944 @default.
- W4313647412 cites W3097464725 @default.
- W4313647412 cites W3116219345 @default.
- W4313647412 cites W3123342582 @default.
- W4313647412 cites W3132784437 @default.
- W4313647412 cites W3145906564 @default.
- W4313647412 cites W3167253627 @default.
- W4313647412 cites W3214910431 @default.
- W4313647412 cites W4206031044 @default.
- W4313647412 cites W4206415950 @default.
- W4313647412 cites W4234401654 @default.
- W4313647412 cites W4246822974 @default.
- W4313647412 cites W4252028806 @default.
- W4313647412 doi "https://doi.org/10.1002/smll.202205682" @default.
- W4313647412 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36604977" @default.
- W4313647412 hasPublicationYear "2023" @default.
- W4313647412 type Work @default.
- W4313647412 citedByCount "4" @default.
- W4313647412 countsByYear W43136474122023 @default.
- W4313647412 crossrefType "journal-article" @default.
- W4313647412 hasAuthorship W4313647412A5031456572 @default.
- W4313647412 hasAuthorship W4313647412A5034821623 @default.
- W4313647412 hasAuthorship W4313647412A5044344398 @default.
- W4313647412 hasAuthorship W4313647412A5065029077 @default.
- W4313647412 hasAuthorship W4313647412A5081244789 @default.
- W4313647412 hasAuthorship W4313647412A5086077764 @default.
- W4313647412 hasAuthorship W4313647412A5090815103 @default.
- W4313647412 hasConcept C150394285 @default.
- W4313647412 hasConcept C178790620 @default.
- W4313647412 hasConcept C179366358 @default.
- W4313647412 hasConcept C181199279 @default.
- W4313647412 hasConcept C185592680 @default.
- W4313647412 hasConcept C2777052132 @default.
- W4313647412 hasConcept C2777468819 @default.
- W4313647412 hasConcept C2779489039 @default.
- W4313647412 hasConcept C27983359 @default.
- W4313647412 hasConcept C501593827 @default.
- W4313647412 hasConcept C515207424 @default.
- W4313647412 hasConcept C523546767 @default.
- W4313647412 hasConcept C54355233 @default.