FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313647416> ?p ?o ?g. }

• W4313647416 abstract "Mounting evidence suggests that the gut microbiome influences radiotherapy efficacy and toxicity by modulating immune signalling. However, its contribution to radiotherapy outcomes in head and neck cancer (HNC) is yet to be investigated. This study, therefore, aimed to uncover associations between an individual's pre-therapy gut microbiota and (i) severity of radiotherapy-induced oral mucositis (OM), and (ii) recurrence risk in patients with HNC.In this prospective pilot study, 20 patients with HNC scheduled to receive radiotherapy or chemoradiotherapy were recruited. Stool samples were collected before treatment and microbial composition was analysed using 16S rRNA gene sequencing. OM severity was assessed using the NCI-CTCAE scoring system. Patients were also followed for 12 months of treatment completion to assess tumour recurrence.Overall, 80% of the patients were male with a median age of 65.5 years. Fifty-three percent experienced mild/moderate OM while 47% developed severe OM. Furthermore, 18% experienced tumour relapse within 1 year of treatment completion. A pre-treatment microbiota enriched of Eubacterium, Victivallis, and Ruminococcus was associated with severe OM. Conversely, a higher relative abundance of immunomodulatory microbes Faecalibacterium, Prevotella, and Phascolarctobacterium was associated with a lower risk of tumour recurrence.Our results indicate that a patient's gut microbiota composition at the start of treatment is linked to OM severity and recurrence risk. We now seek to validate these findings to determine their ability to predict treatment outcomes in HNC, with the goal of using this data to inform second-generation microbial therapeutics to optimise treatment outcomes for patients with HNC." @default.
• W4313647416 created "2023-01-07" @default.
• W4313647416 creator A5015543670 @default.
• W4313647416 creator A5015659735 @default.
• W4313647416 creator A5032807426 @default.
• W4313647416 creator A5035480544 @default.
• W4313647416 creator A5049546535 @default.
• W4313647416 creator A5052756021 @default.
• W4313647416 creator A5079301265 @default.
• W4313647416 creator A5087396617 @default.
• W4313647416 date "2023-01-01" @default.
• W4313647416 modified "2023-09-29" @default.
• W4313647416 title "Baseline gut microbiota composition is associated with oral mucositis and tumour recurrence in patients with head and neck cancer: a pilot study" @default.
• W4313647416 cites W113889136 @default.
• W4313647416 cites W1969643399 @default.
• W4313647416 cites W1985144544 @default.
• W4313647416 cites W2003601710 @default.
• W4313647416 cites W2025743557 @default.
• W4313647416 cites W2032957625 @default.
• W4313647416 cites W2088192427 @default.
• W4313647416 cites W2100357321 @default.
• W4313647416 cites W2121288264 @default.
• W4313647416 cites W2133856765 @default.
• W4313647416 cites W2147825765 @default.
• W4313647416 cites W2311435220 @default.
• W4313647416 cites W2583590098 @default.
• W4313647416 cites W2592084636 @default.
• W4313647416 cites W2595926651 @default.
• W4313647416 cites W2620329934 @default.
• W4313647416 cites W2766903152 @default.
• W4313647416 cites W2791377189 @default.
• W4313647416 cites W2805842814 @default.
• W4313647416 cites W2894856581 @default.
• W4313647416 cites W2922847497 @default.
• W4313647416 cites W2926337143 @default.
• W4313647416 cites W2942123458 @default.
• W4313647416 cites W2951518977 @default.
• W4313647416 cites W2969829464 @default.
• W4313647416 cites W2993330612 @default.
• W4313647416 cites W3000627280 @default.
• W4313647416 cites W3014573611 @default.
• W4313647416 cites W3037791477 @default.
• W4313647416 cites W3081548621 @default.
• W4313647416 cites W3083776046 @default.
• W4313647416 cites W3086669575 @default.
• W4313647416 cites W3089141133 @default.
• W4313647416 cites W3094313667 @default.
• W4313647416 cites W3097939988 @default.
• W4313647416 cites W3106917142 @default.
• W4313647416 cites W3119728657 @default.
• W4313647416 cites W3123341271 @default.
• W4313647416 cites W3128646645 @default.
• W4313647416 cites W3173290336 @default.
• W4313647416 cites W4220737636 @default.
• W4313647416 cites W4221010174 @default.
• W4313647416 cites W4289130406 @default.
• W4313647416 cites W825189406 @default.
• W4313647416 doi "https://doi.org/10.1007/s00520-022-07559-5" @default.
• W4313647416 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36607434" @default.
• W4313647416 hasPublicationYear "2023" @default.
• W4313647416 type Work @default.
• W4313647416 citedByCount "5" @default.
• W4313647416 countsByYear W43136474162023 @default.
• W4313647416 crossrefType "journal-article" @default.
• W4313647416 hasAuthorship W4313647416A5015543670 @default.
• W4313647416 hasAuthorship W4313647416A5015659735 @default.
• W4313647416 hasAuthorship W4313647416A5032807426 @default.
• W4313647416 hasAuthorship W4313647416A5035480544 @default.
• W4313647416 hasAuthorship W4313647416A5049546535 @default.
• W4313647416 hasAuthorship W4313647416A5052756021 @default.
• W4313647416 hasAuthorship W4313647416A5079301265 @default.
• W4313647416 hasAuthorship W4313647416A5087396617 @default.
• W4313647416 hasBestOaLocation W43136474162 @default.
• W4313647416 hasConcept C121608353 @default.
• W4313647416 hasConcept C126322002 @default.
• W4313647416 hasConcept C143998085 @default.
• W4313647416 hasConcept C203014093 @default.
• W4313647416 hasConcept C2776530083 @default.
• W4313647416 hasConcept C2778424827 @default.
• W4313647416 hasConcept C2778496288 @default.
• W4313647416 hasConcept C2780140570 @default.
• W4313647416 hasConcept C2780423288 @default.
• W4313647416 hasConcept C509974204 @default.
• W4313647416 hasConcept C523546767 @default.
• W4313647416 hasConcept C539455810 @default.
• W4313647416 hasConcept C54355233 @default.
• W4313647416 hasConcept C71924100 @default.
• W4313647416 hasConcept C86803240 @default.
• W4313647416 hasConcept C90924648 @default.
• W4313647416 hasConceptScore W4313647416C121608353 @default.
• W4313647416 hasConceptScore W4313647416C126322002 @default.
• W4313647416 hasConceptScore W4313647416C143998085 @default.
• W4313647416 hasConceptScore W4313647416C203014093 @default.
• W4313647416 hasConceptScore W4313647416C2776530083 @default.
• W4313647416 hasConceptScore W4313647416C2778424827 @default.
• W4313647416 hasConceptScore W4313647416C2778496288 @default.
• W4313647416 hasConceptScore W4313647416C2780140570 @default.
• W4313647416 hasConceptScore W4313647416C2780423288 @default.
• W4313647416 hasConceptScore W4313647416C509974204 @default.
• W4313647416 hasConceptScore W4313647416C523546767 @default.

• next