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- W4313647428 abstract "Fourfold degenerate sites within coding regions and intergenic sites have both been used as estimates of neutral evolution. In chloroplast DNA, the pattern of substitution at intergenic sites is strongly dependent on the composition of the surrounding hexanucleotide composed of the three base pairs on each side, which suggests that the mutation process is highly context-dependent in this genome. This study examines the context-dependency of substitutions at fourfold degenerate sites in protein-coding regions and compares the pattern to what has been observed at intergenic sites. Overall, there is strong similarity between the two types of sites, but there are some intriguing differences. One of these is that substitutions of G and C are significantly higher at fourfold degenerate sites across a range of contexts. In fact, A → T and T → A substitutions are the only substitution types that occur at a lower rate at fourfold degenerate sites. The data are not consistent with selective constraints being responsible for the difference in substitution patterns between intergenic and fourfold degenerate sites. Rather, it is suggested that the difference may be a result of different epigenetic modifications that result in slightly different mutation patterns in coding and intergenic DNA." @default.
- W4313647428 created "2023-01-07" @default.
- W4313647428 creator A5016889796 @default.
- W4313647428 date "2023-01-05" @default.
- W4313647428 modified "2023-09-26" @default.
- W4313647428 title "Do Noncoding and Coding Sites in Angiosperm Chloroplast DNA Have Different Mutation Processes?" @default.
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- W4313647428 doi "https://doi.org/10.3390/genes14010148" @default.
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