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- W4313647429 endingPage "147171" @default.
- W4313647429 startingPage "147171" @default.
- W4313647429 abstract "The human cytochrome P450 1A (CYP1A) subfamily genes, CYP1A1 and CYP1A2, encoding monooxygenases are critically involved in biotransformation of key endogenous substrates (estradiol, arachidonic acid, cholesterol) and exogenous compounds (smoke constituents, carcinogens, caffeine, therapeutic drugs). This suggests their significant involvement in multiple biological pathways with a primary role of maintaining endogenous homeostasis and xenobiotic detoxification. Large interindividual variability exist in CYP1A gene expression and/or catalytic activity of the enzyme, which is primarily due to the existence of polymorphic alleles which encode them. These polymorphisms (mainly single nucleotide polymorphisms, SNPs) have been extensively studied as susceptibility factors in a spectrum of clinical phenotypes. An in-depth understanding of the effects of polymorphic CYP1A genes on the differential metabolic activity and the resulting biological pathways is needed to explain the clinical implications of CYP1A polymorphisms. The present review is intended to provide an integrated understanding of CYP1A metabolic activity with unique substrate specificity and their involvement in physiological and pathophysiological roles. The article further emphasizes on the impact of widely studied CYP1A1 and CYP1A2 SNPs and their complex interaction with non-genetic factors like smoking and caffeine intake on multiple clinical phenotypes. Finally, we attempted to discuss the alterations in metabolism/physiology concerning the polymorphic CYP1A genes, which may underlie the reported clinical associations. This knowledge may provide insights into the disease pathogenesis, risk stratification, response to therapy and potential drug targets for individuals with certain CYP1A genotypes." @default.
- W4313647429 created "2023-01-07" @default.
- W4313647429 creator A5020240904 @default.
- W4313647429 creator A5020296033 @default.
- W4313647429 creator A5044103955 @default.
- W4313647429 creator A5051683315 @default.
- W4313647429 creator A5054248469 @default.
- W4313647429 creator A5067117356 @default.
- W4313647429 creator A5081337811 @default.
- W4313647429 creator A5091274298 @default.
- W4313647429 date "2023-03-01" @default.
- W4313647429 modified "2023-10-18" @default.
- W4313647429 title "Genic-intergenic polymorphisms of CYP1A genes and their clinical impact" @default.
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