FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313647656> ?p ?o ?g. }

• W4313647656 abstract "Diffuse malignant peritoneal mesothelioma (DMPM) is an unusual and life-threatening locally invasive tumor. The morbidity and mortality of the disease are associated with progressive local effects in the abdominal cavity, such as abdominal distention, painful sensations, and early saturation with reduced oral intake, which eventually lead to intestinal obstruction and cachexia. Computed tomography (CT) has been widely used as a first-line diagnostic tool for DMPM. In addition, the most sensitive immunohistochemical markers of DMPM include WT 1, D2-40, and calmodulin. This paradigm has altered with the advancements in the immunohistochemical analysis of BRCA1-Associated Protein 1 (BAP1) the lack of BAP1 expression shows the diagnosis of malignancy. DMPM is resistant to conventional chemotherapies. Therefore, the gold standard for the treatment of DMPM is the combination of cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). The overexpression of the phosphatidylinositol 3-kinase (PI3K)/AKT serine/threonine kinase 1 (AKT)/mammalian target of rapamycin (mTOR) signaling pathway drives the malignant phenotype of DMPM, thereby showing promising potential for the treatment of DMPM. The coordinated activities among multiple RTKs are directly involved in the biological processes of DMPM, suggesting that the combined inhibition of the PI3K and mTOR signaling pathways might be an effective measure. This treatment strategy can be easily implemented in clinical practice. However, the combined inhibition of ERBB1(HER1)/ERBB2 (HER2) and ERBB3 (HER3) requires further investigations. Thus, based on these, the discovery of novel targeted therapies might be crucial to improving the prognosis of DMPM patients." @default.
• W4313647656 created "2023-01-07" @default.
• W4313647656 creator A5017471172 @default.
• W4313647656 creator A5057631509 @default.
• W4313647656 creator A5090215277 @default.
• W4313647656 date "2023-01-06" @default.
• W4313647656 modified "2023-09-30" @default.
• W4313647656 title "Diffuse malignant peritoneal mesothelioma: A review" @default.
• W4313647656 cites W102573316 @default.
• W4313647656 cites W1549826789 @default.
• W4313647656 cites W1769024417 @default.
• W4313647656 cites W1964231300 @default.
• W4313647656 cites W1975191306 @default.
• W4313647656 cites W1978011918 @default.
• W4313647656 cites W1982173356 @default.
• W4313647656 cites W1982893217 @default.
• W4313647656 cites W1989692824 @default.
• W4313647656 cites W1990766534 @default.
• W4313647656 cites W1992718174 @default.
• W4313647656 cites W2002819940 @default.
• W4313647656 cites W2008627607 @default.
• W4313647656 cites W2016343650 @default.
• W4313647656 cites W2024368570 @default.
• W4313647656 cites W2031203833 @default.
• W4313647656 cites W2033576373 @default.
• W4313647656 cites W2045203690 @default.
• W4313647656 cites W2051645140 @default.
• W4313647656 cites W2052280409 @default.
• W4313647656 cites W2060760531 @default.
• W4313647656 cites W2062804725 @default.
• W4313647656 cites W2063081550 @default.
• W4313647656 cites W2066343477 @default.
• W4313647656 cites W2068763072 @default.
• W4313647656 cites W2077102071 @default.
• W4313647656 cites W2102627969 @default.
• W4313647656 cites W2128052076 @default.
• W4313647656 cites W2158757628 @default.
• W4313647656 cites W2166116307 @default.
• W4313647656 cites W2186526646 @default.
• W4313647656 cites W2223722125 @default.
• W4313647656 cites W2336280419 @default.
• W4313647656 cites W2432825906 @default.
• W4313647656 cites W2510214769 @default.
• W4313647656 cites W2514452913 @default.
• W4313647656 cites W2522587390 @default.
• W4313647656 cites W2541860052 @default.
• W4313647656 cites W2561272516 @default.
• W4313647656 cites W2580822306 @default.
• W4313647656 cites W2593233944 @default.
• W4313647656 cites W2789493530 @default.
• W4313647656 cites W2920789566 @default.
• W4313647656 cites W2953549691 @default.
• W4313647656 cites W2990834096 @default.
• W4313647656 cites W2995886480 @default.
• W4313647656 cites W3011615845 @default.
• W4313647656 cites W3012770963 @default.
• W4313647656 cites W3164572586 @default.
• W4313647656 cites W4236419946 @default.
• W4313647656 cites W4237759806 @default.
• W4313647656 cites W4256149964 @default.
• W4313647656 cites W4282829033 @default.
• W4313647656 cites W2131061438 @default.
• W4313647656 doi "https://doi.org/10.3389/fsurg.2022.1015884" @default.
• W4313647656 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36684194" @default.
• W4313647656 hasPublicationYear "2023" @default.
• W4313647656 type Work @default.
• W4313647656 citedByCount "1" @default.
• W4313647656 countsByYear W43136476562023 @default.
• W4313647656 crossrefType "journal-article" @default.
• W4313647656 hasAuthorship W4313647656A5017471172 @default.
• W4313647656 hasAuthorship W4313647656A5057631509 @default.
• W4313647656 hasAuthorship W4313647656A5090215277 @default.
• W4313647656 hasBestOaLocation W43136476561 @default.
• W4313647656 hasConcept C142724271 @default.
• W4313647656 hasConcept C2777407522 @default.
• W4313647656 hasConcept C2778995398 @default.
• W4313647656 hasConcept C2779399171 @default.
• W4313647656 hasConcept C502942594 @default.
• W4313647656 hasConcept C55493867 @default.
• W4313647656 hasConcept C62478195 @default.
• W4313647656 hasConcept C71924100 @default.
• W4313647656 hasConcept C75217442 @default.
• W4313647656 hasConcept C86554907 @default.
• W4313647656 hasConcept C86803240 @default.
• W4313647656 hasConceptScore W4313647656C142724271 @default.
• W4313647656 hasConceptScore W4313647656C2777407522 @default.
• W4313647656 hasConceptScore W4313647656C2778995398 @default.
• W4313647656 hasConceptScore W4313647656C2779399171 @default.
• W4313647656 hasConceptScore W4313647656C502942594 @default.
• W4313647656 hasConceptScore W4313647656C55493867 @default.
• W4313647656 hasConceptScore W4313647656C62478195 @default.
• W4313647656 hasConceptScore W4313647656C71924100 @default.
• W4313647656 hasConceptScore W4313647656C75217442 @default.
• W4313647656 hasConceptScore W4313647656C86554907 @default.
• W4313647656 hasConceptScore W4313647656C86803240 @default.
• W4313647656 hasLocation W43136476561 @default.
• W4313647656 hasLocation W43136476562 @default.
• W4313647656 hasLocation W43136476563 @default.
• W4313647656 hasOpenAccess W4313647656 @default.
• W4313647656 hasPrimaryLocation W43136476561 @default.

• next