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- W4313647932 abstract "Abstract Label-free chemical and structural imaging of complex living tissue and biological systems is the holy grail of biomedical research and clinical diagnostics. The current analysis techniques are time-consuming and/or require extensive sample preparation, often due to the presence of interfering molecules such as water, making them unsuitable for the analysis of such systems. Here, we demonstrate a proof-of-principle study using label-free optical photothermal mid-infrared microspectroscopy (O-PTIR) for fast, direct spatiotemporal chemical analysis of complex living biological systems at submicron resolution. While other analytical methods can provide only static snapshots of molecular structures, our O-PTIR approach enables time-resolved and in situ investigation of chemical and structural changes of diverse biomolecules in their native conditions. This comprises a technological breakthrough in infrared spectroscopy to analyze biomolecules under native conditions over time: in fresh unprocessed biopsies, living brain tissue, and vertebrates without compromising their viability. One-Sentence Summary Proof-of-principle application of non-destructive O-PTIR for high-resolution spatiotemporal chemical and structural analysis of unprocessed biopsies, living brain tissue, and vertebrates." @default.
- W4313647932 created "2023-01-07" @default.
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- W4313647932 date "2023-01-05" @default.
- W4313647932 modified "2023-10-01" @default.
- W4313647932 title "Label-free high-resolution infrared spectroscopy for spatiotemporal analysis of complex living systems" @default.
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- W4313647932 doi "https://doi.org/10.1101/2023.01.05.522847" @default.
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