Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313647984> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W4313647984 abstract "Abstract Purpose Both monogenic autoinflammatory syndromes, such as Chronic Granulomatous Disease (CGD) and Familial Mediterranean Fever (FMF), and the common inflammatory disease gout are characterized by episodes of sterile inflammatory attacks in the absence of an infection. While these disorders encompass distinct pathologies due to differentially affected metabolic pathways and inflammasome activation mechanisms, their common features are the excessive production of interleukin (IL)-1ß and innate immune cell hyperreactivity. On the other hand, the role of T cells and innate-like lymphocytes such as gamma delta (γδ) T cells in these pathologies is ill-defined. Methods In order to widen our understanding of T cell involvement in FMF, CGD and gout pathology we developed multicolour immunophenotyping panels for flow cytometry and functional assays to characterise gd T cells, as well as CD4 and CD8 T cell populations in terms of their cytokine production, activation status, memory or naive phenotypes, exhaustion status, homing receptor expression, and cytotoxic activity. Results Our study is the first deep immunophenotyping analysis of T cell populations in FMF, CGD and gout patients. We found that CGD affects the frequencies and activation status of T cells, while gout impairs cytokine production capacity of Vd2 T cells and reshapes homing receptor expression by T cells. FMF was characterized by only minor effects on T cell populations. Conclusion Autoinflammatory syndromes differentially affect T cell compartments. Future studies are warranted to assess whether these phenotypical changes are relevant for disease pathology." @default.
- W4313647984 created "2023-01-07" @default.
- W4313647984 creator A5012082877 @default.
- W4313647984 creator A5017907898 @default.
- W4313647984 creator A5027955775 @default.
- W4313647984 creator A5030845823 @default.
- W4313647984 creator A5036752858 @default.
- W4313647984 creator A5047090114 @default.
- W4313647984 creator A5049829923 @default.
- W4313647984 creator A5067669061 @default.
- W4313647984 creator A5071761179 @default.
- W4313647984 creator A5074735964 @default.
- W4313647984 creator A5081469417 @default.
- W4313647984 creator A5081487979 @default.
- W4313647984 date "2023-01-06" @default.
- W4313647984 modified "2023-09-27" @default.
- W4313647984 title "Peripheral T cell populations are differentially affected in monogenic autoinflammatory syndromes and gout" @default.
- W4313647984 doi "https://doi.org/10.21203/rs.3.rs-2421679/v1" @default.
- W4313647984 hasPublicationYear "2023" @default.
- W4313647984 type Work @default.
- W4313647984 citedByCount "0" @default.
- W4313647984 crossrefType "posted-content" @default.
- W4313647984 hasAuthorship W4313647984A5012082877 @default.
- W4313647984 hasAuthorship W4313647984A5017907898 @default.
- W4313647984 hasAuthorship W4313647984A5027955775 @default.
- W4313647984 hasAuthorship W4313647984A5030845823 @default.
- W4313647984 hasAuthorship W4313647984A5036752858 @default.
- W4313647984 hasAuthorship W4313647984A5047090114 @default.
- W4313647984 hasAuthorship W4313647984A5049829923 @default.
- W4313647984 hasAuthorship W4313647984A5067669061 @default.
- W4313647984 hasAuthorship W4313647984A5071761179 @default.
- W4313647984 hasAuthorship W4313647984A5074735964 @default.
- W4313647984 hasAuthorship W4313647984A5081469417 @default.
- W4313647984 hasAuthorship W4313647984A5081487979 @default.
- W4313647984 hasBestOaLocation W43136479841 @default.
- W4313647984 hasConcept C126322002 @default.
- W4313647984 hasConcept C142724271 @default.
- W4313647984 hasConcept C154317977 @default.
- W4313647984 hasConcept C162157009 @default.
- W4313647984 hasConcept C167672396 @default.
- W4313647984 hasConcept C19317047 @default.
- W4313647984 hasConcept C196166836 @default.
- W4313647984 hasConcept C202751555 @default.
- W4313647984 hasConcept C203014093 @default.
- W4313647984 hasConcept C2775982045 @default.
- W4313647984 hasConcept C2776090121 @default.
- W4313647984 hasConcept C2776914184 @default.
- W4313647984 hasConcept C2777209026 @default.
- W4313647984 hasConcept C2778690821 @default.
- W4313647984 hasConcept C2779134260 @default.
- W4313647984 hasConcept C2779537928 @default.
- W4313647984 hasConcept C2780402116 @default.
- W4313647984 hasConcept C54355233 @default.
- W4313647984 hasConcept C553184892 @default.
- W4313647984 hasConcept C71924100 @default.
- W4313647984 hasConcept C86803240 @default.
- W4313647984 hasConcept C8891405 @default.
- W4313647984 hasConceptScore W4313647984C126322002 @default.
- W4313647984 hasConceptScore W4313647984C142724271 @default.
- W4313647984 hasConceptScore W4313647984C154317977 @default.
- W4313647984 hasConceptScore W4313647984C162157009 @default.
- W4313647984 hasConceptScore W4313647984C167672396 @default.
- W4313647984 hasConceptScore W4313647984C19317047 @default.
- W4313647984 hasConceptScore W4313647984C196166836 @default.
- W4313647984 hasConceptScore W4313647984C202751555 @default.
- W4313647984 hasConceptScore W4313647984C203014093 @default.
- W4313647984 hasConceptScore W4313647984C2775982045 @default.
- W4313647984 hasConceptScore W4313647984C2776090121 @default.
- W4313647984 hasConceptScore W4313647984C2776914184 @default.
- W4313647984 hasConceptScore W4313647984C2777209026 @default.
- W4313647984 hasConceptScore W4313647984C2778690821 @default.
- W4313647984 hasConceptScore W4313647984C2779134260 @default.
- W4313647984 hasConceptScore W4313647984C2779537928 @default.
- W4313647984 hasConceptScore W4313647984C2780402116 @default.
- W4313647984 hasConceptScore W4313647984C54355233 @default.
- W4313647984 hasConceptScore W4313647984C553184892 @default.
- W4313647984 hasConceptScore W4313647984C71924100 @default.
- W4313647984 hasConceptScore W4313647984C86803240 @default.
- W4313647984 hasConceptScore W4313647984C8891405 @default.
- W4313647984 hasLocation W43136479841 @default.
- W4313647984 hasOpenAccess W4313647984 @default.
- W4313647984 hasPrimaryLocation W43136479841 @default.
- W4313647984 hasRelatedWork W1929024384 @default.
- W4313647984 hasRelatedWork W1971090658 @default.
- W4313647984 hasRelatedWork W2047525024 @default.
- W4313647984 hasRelatedWork W2048551300 @default.
- W4313647984 hasRelatedWork W2052372148 @default.
- W4313647984 hasRelatedWork W2053829632 @default.
- W4313647984 hasRelatedWork W2163337422 @default.
- W4313647984 hasRelatedWork W3007543719 @default.
- W4313647984 hasRelatedWork W4313647984 @default.
- W4313647984 hasRelatedWork W4381033527 @default.
- W4313647984 isParatext "false" @default.
- W4313647984 isRetracted "false" @default.
- W4313647984 workType "article" @default.