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- W4313648279 abstract "Molecular subtypes including the normal-like subtype drive patient outcomes in human breast cancer but the biological basis underlying subtype-specific disease is not completely understood (1-4). We mined published microarray data (5, 6) to discover in an unbiased fashion the most distinguishing genetic and transcriptional features of tumors of each breast cancer molecular subtype. We identified a single nucleotide polymorphism, rs572729, residing within PIEZO2, as among the most significant genetic differences in the tumors of patients with normal-like breast cancer. In a separate cohort of patients with normal-like subtype breast cancer, we could not identify a differentially expressed PIEZO2 transcript. Analysis of patient survival data revealed that PIEZO2 primary tumor expression was correlated with overall survival in patients with normal-like breast cancer. Sequence variation in the PIEZO2 gene may be important in understanding differences in genetic background that favor development of normal-like subtype human breast cancer." @default.
- W4313648279 created "2023-01-07" @default.
- W4313648279 creator A5024900493 @default.
- W4313648279 date "2023-01-06" @default.
- W4313648279 modified "2023-09-29" @default.
- W4313648279 title "A single nucleotide variant on chromosome 18 residing within PIEZO2 distinguishes patients with normal-like breast cancer." @default.
- W4313648279 doi "https://doi.org/10.31219/osf.io/274hn" @default.
- W4313648279 hasPublicationYear "2023" @default.
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