FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313648319> ?p ?o ?g. }

• W4313648319 abstract "This review surveys the causes and consequences of DNA damage in the male germ line from spermatogonial stem cells to fully differentiated spermatozoa. Within the stem cell population, DNA integrity is well maintained as a result of excellent DNA surveillance and repair; however, a progressive increase in background mutation rates does occur with paternal age possibly as a result of aberrant DNA repair as well as replication error. Once a germ cell has committed to spermatogenesis, it responds to genetic damage via a range of DNA repair pathways or, if this process fails, by the induction of apoptosis. When fully-differentiated spermatozoa are stressed, they also activate a truncated intrinsic apoptotic pathway which results in the activation of nucleases in the mitochondria and cytoplasm; however, the physical architecture of these cells prevents these enzymes from translocating to the nucleus to induce DNA fragmentation. Conversely, hydrogen peroxide released from the sperm midpiece during apoptosis is able to penetrate the nucleus and induce DNA damage. The base excision repair pathway responds to such damage by cleaving oxidized bases from the DNA, leaving abasic sites that are alkali-labile and readily detected with the comet assay. As levels of oxidative stress increase and these cells enter the perimortem, topoisomerase integrated into the sperm chromatin becomes activated by SUMOylation. Such activation may initially facilitate DNA repair by reannealing double strand breaks but ultimately prepares the DNA for destruction by nucleases released from the male reproductive tract. The abasic sites and oxidized base lesions found in live spermatozoa are mutagenic and may increase the mutational load carried by the offspring, particularly in the context of assisted conception. A variety of strategies are described for managing patients expressing high levels of DNA damage in their spermatozoa, to reduce the risks such lesions might pose to offspring health." @default.
• W4313648319 created "2023-01-07" @default.
• W4313648319 creator A5071595215 @default.
• W4313648319 creator A5075142529 @default.
• W4313648319 date "2023-01-16" @default.
• W4313648319 modified "2023-10-01" @default.
• W4313648319 title "DNA damage in testicular germ cells and spermatozoa. When and how is it induced? How should we measure it? What does it mean?" @default.
• W4313648319 cites W1097888740 @default.
• W4313648319 cites W1731057385 @default.
• W4313648319 cites W1816176398 @default.
• W4313648319 cites W1972411943 @default.
• W4313648319 cites W1974720537 @default.
• W4313648319 cites W1983919388 @default.
• W4313648319 cites W2010786205 @default.
• W4313648319 cites W2013956963 @default.
• W4313648319 cites W2036119249 @default.
• W4313648319 cites W2056114779 @default.
• W4313648319 cites W2061934492 @default.
• W4313648319 cites W2077751281 @default.
• W4313648319 cites W2077933167 @default.
• W4313648319 cites W2078815410 @default.
• W4313648319 cites W2096191845 @default.
• W4313648319 cites W2104119798 @default.
• W4313648319 cites W2106855468 @default.
• W4313648319 cites W2107825545 @default.
• W4313648319 cites W2112400063 @default.
• W4313648319 cites W2112948530 @default.
• W4313648319 cites W2115524920 @default.
• W4313648319 cites W2121915991 @default.
• W4313648319 cites W2123070568 @default.
• W4313648319 cites W2126608167 @default.
• W4313648319 cites W2128189777 @default.
• W4313648319 cites W2135247098 @default.
• W4313648319 cites W2141565053 @default.
• W4313648319 cites W2142383155 @default.
• W4313648319 cites W2142451890 @default.
• W4313648319 cites W2148640009 @default.
• W4313648319 cites W2151257983 @default.
• W4313648319 cites W2157338653 @default.
• W4313648319 cites W2161506037 @default.
• W4313648319 cites W2161623161 @default.
• W4313648319 cites W2162571700 @default.
• W4313648319 cites W2164040776 @default.
• W4313648319 cites W2171660278 @default.
• W4313648319 cites W2242000780 @default.
• W4313648319 cites W2289658474 @default.
• W4313648319 cites W2330768224 @default.
• W4313648319 cites W2462226918 @default.
• W4313648319 cites W2525362313 @default.
• W4313648319 cites W2555428382 @default.
• W4313648319 cites W2606220822 @default.
• W4313648319 cites W2747431681 @default.
• W4313648319 cites W2752290922 @default.
• W4313648319 cites W2792144008 @default.
• W4313648319 cites W2798191249 @default.
• W4313648319 cites W2800641073 @default.
• W4313648319 cites W2909418795 @default.
• W4313648319 cites W2919944057 @default.
• W4313648319 cites W2920321917 @default.
• W4313648319 cites W2923967904 @default.
• W4313648319 cites W2948340865 @default.
• W4313648319 cites W2949269627 @default.
• W4313648319 cites W2952956750 @default.
• W4313648319 cites W2979658442 @default.
• W4313648319 cites W2981632647 @default.
• W4313648319 cites W2996282512 @default.
• W4313648319 cites W3049631314 @default.
• W4313648319 cites W3082699693 @default.
• W4313648319 cites W3087127281 @default.
• W4313648319 cites W3110849358 @default.
• W4313648319 cites W3111127730 @default.
• W4313648319 cites W3128790078 @default.
• W4313648319 cites W3133554797 @default.
• W4313648319 cites W31337204 @default.
• W4313648319 cites W3157808945 @default.
• W4313648319 cites W3161599640 @default.
• W4313648319 cites W3169861322 @default.
• W4313648319 cites W3176198688 @default.
• W4313648319 cites W3193768023 @default.
• W4313648319 cites W3200186397 @default.
• W4313648319 cites W3202480654 @default.
• W4313648319 cites W3215978125 @default.
• W4313648319 cites W4210268602 @default.
• W4313648319 cites W4210737485 @default.
• W4313648319 cites W4214866818 @default.
• W4313648319 cites W4220773743 @default.
• W4313648319 cites W4221033710 @default.
• W4313648319 cites W4223541284 @default.
• W4313648319 cites W4229962779 @default.
• W4313648319 cites W4282567180 @default.
• W4313648319 cites W4283167446 @default.
• W4313648319 cites W4283220449 @default.
• W4313648319 cites W4283270205 @default.
• W4313648319 cites W4283520927 @default.
• W4313648319 cites W4283836122 @default.
• W4313648319 cites W4284881618 @default.
• W4313648319 cites W4285741799 @default.
• W4313648319 cites W4285821914 @default.
• W4313648319 cites W4289840715 @default.
• W4313648319 cites W4289856202 @default.

• next