Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313648623> ?p ?o ?g. }
- W4313648623 abstract "Abstract Immune intervention of B cell activation to blockade the production of autoantibodies provokes intense interest in the field of systemic lupus erythematosus (SLE) therapy development. Although the survival rate for SLE is improved, many patients die untimely. Engineered cell membrane vesicles manifest remarkable capacity of targeted drug delivery and immunomodulation of immune cells such as B cells. Herein, this work engineered cellular nanovesicles (NVs) presenting CD40 (CD40 NVs) that can blunt B cells and thus alleviate SLE. CD40 NVs disrupt the CD40/CD40 ligand (CD40L) costimulatory signal axis through the blockade of CD40L on CD4 + T cells. Therefore, the CD40 NVs restrain the generation of the germinal center structure and production of antibodies from B cells. Furthermore, immunosuppressive drug mycophenolate mofetil (MMF) is also encapsulated in the vesicles (MMF‐CD40 NVs), which is employed to deplete immunocytes including B cells, T cells, and dendritic cells. Together, CD40 NVs are promising formulations for relieving autoimmunity and lupus nephritis in MRL/lpr mice." @default.
- W4313648623 created "2023-01-07" @default.
- W4313648623 creator A5000426662 @default.
- W4313648623 creator A5008056710 @default.
- W4313648623 creator A5012411293 @default.
- W4313648623 creator A5026889770 @default.
- W4313648623 creator A5033430858 @default.
- W4313648623 creator A5036055293 @default.
- W4313648623 creator A5036811947 @default.
- W4313648623 creator A5037572759 @default.
- W4313648623 creator A5043066588 @default.
- W4313648623 creator A5048521956 @default.
- W4313648623 creator A5049692788 @default.
- W4313648623 creator A5056289025 @default.
- W4313648623 creator A5063921153 @default.
- W4313648623 creator A5066285868 @default.
- W4313648623 creator A5071913673 @default.
- W4313648623 creator A5079722320 @default.
- W4313648623 creator A5082857859 @default.
- W4313648623 creator A5087592842 @default.
- W4313648623 date "2023-01-05" @default.
- W4313648623 modified "2023-10-15" @default.
- W4313648623 title "Engineered Cell Membrane Vesicles Expressing CD40 Alleviate System Lupus Nephritis by Intervening B Cell Activation" @default.
- W4313648623 cites W1970480652 @default.
- W4313648623 cites W1986321004 @default.
- W4313648623 cites W2009154052 @default.
- W4313648623 cites W2017390384 @default.
- W4313648623 cites W2024104456 @default.
- W4313648623 cites W2044835583 @default.
- W4313648623 cites W2786202610 @default.
- W4313648623 cites W2794299057 @default.
- W4313648623 cites W2799662486 @default.
- W4313648623 cites W2805930941 @default.
- W4313648623 cites W2809820519 @default.
- W4313648623 cites W2888732282 @default.
- W4313648623 cites W2899041727 @default.
- W4313648623 cites W2912361307 @default.
- W4313648623 cites W2921184502 @default.
- W4313648623 cites W2937184143 @default.
- W4313648623 cites W2938506185 @default.
- W4313648623 cites W2948946994 @default.
- W4313648623 cites W2967918238 @default.
- W4313648623 cites W2979822262 @default.
- W4313648623 cites W2983232980 @default.
- W4313648623 cites W2996423407 @default.
- W4313648623 cites W3027012949 @default.
- W4313648623 cites W3028225604 @default.
- W4313648623 cites W3030080235 @default.
- W4313648623 cites W3047868968 @default.
- W4313648623 cites W3124490206 @default.
- W4313648623 cites W3173043499 @default.
- W4313648623 cites W3179409394 @default.
- W4313648623 cites W3182079070 @default.
- W4313648623 cites W3192871908 @default.
- W4313648623 doi "https://doi.org/10.1002/smtd.202200925" @default.
- W4313648623 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36605001" @default.
- W4313648623 hasPublicationYear "2023" @default.
- W4313648623 type Work @default.
- W4313648623 citedByCount "2" @default.
- W4313648623 countsByYear W43136486232023 @default.
- W4313648623 crossrefType "journal-article" @default.
- W4313648623 hasAuthorship W4313648623A5000426662 @default.
- W4313648623 hasAuthorship W4313648623A5008056710 @default.
- W4313648623 hasAuthorship W4313648623A5012411293 @default.
- W4313648623 hasAuthorship W4313648623A5026889770 @default.
- W4313648623 hasAuthorship W4313648623A5033430858 @default.
- W4313648623 hasAuthorship W4313648623A5036055293 @default.
- W4313648623 hasAuthorship W4313648623A5036811947 @default.
- W4313648623 hasAuthorship W4313648623A5037572759 @default.
- W4313648623 hasAuthorship W4313648623A5043066588 @default.
- W4313648623 hasAuthorship W4313648623A5048521956 @default.
- W4313648623 hasAuthorship W4313648623A5049692788 @default.
- W4313648623 hasAuthorship W4313648623A5056289025 @default.
- W4313648623 hasAuthorship W4313648623A5063921153 @default.
- W4313648623 hasAuthorship W4313648623A5066285868 @default.
- W4313648623 hasAuthorship W4313648623A5071913673 @default.
- W4313648623 hasAuthorship W4313648623A5079722320 @default.
- W4313648623 hasAuthorship W4313648623A5082857859 @default.
- W4313648623 hasAuthorship W4313648623A5087592842 @default.
- W4313648623 hasConcept C126322002 @default.
- W4313648623 hasConcept C154317977 @default.
- W4313648623 hasConcept C159654299 @default.
- W4313648623 hasConcept C163764329 @default.
- W4313648623 hasConcept C185592680 @default.
- W4313648623 hasConcept C202751555 @default.
- W4313648623 hasConcept C203014093 @default.
- W4313648623 hasConcept C2776912625 @default.
- W4313648623 hasConcept C2778453870 @default.
- W4313648623 hasConcept C2779134260 @default.
- W4313648623 hasConcept C2779912601 @default.
- W4313648623 hasConcept C39347974 @default.
- W4313648623 hasConcept C55493867 @default.
- W4313648623 hasConcept C71924100 @default.
- W4313648623 hasConcept C86803240 @default.
- W4313648623 hasConcept C8891405 @default.
- W4313648623 hasConcept C95444343 @default.
- W4313648623 hasConcept C96926380 @default.
- W4313648623 hasConceptScore W4313648623C126322002 @default.
- W4313648623 hasConceptScore W4313648623C154317977 @default.
- W4313648623 hasConceptScore W4313648623C159654299 @default.