Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313648637> ?p ?o ?g. }
- W4313648637 endingPage "1099" @default.
- W4313648637 startingPage "1099" @default.
- W4313648637 abstract "Ataxia-telangiectasia (AT) is a multisystemic neurodegenerative inborn error of immunity (IEI) characterized by DNA repair defect, chromosomal instability, and hypersensitivity to ionizing radiation. Impaired DNA double-strand break repair determines a high risk of developing hematological malignancies, especially lymphoproliferative diseases. Poor response to treatment, excessive chemotherapy toxicities, and the need for avoiding exposure to ionizing radiation make the successful clinical management of patients with AT challenging for oncologists. We describe the favorable outcome of the LBCL with IRF4 rearrangement at stage III in a 7-year-old female patient diagnosed with AT. The patient was treated according to the B-HR arm of the INTER-B-NHL-COP 2010 protocol, including the administration of rituximab, cyclophosphamide, methotrexate, prednisone, etc. She presented excessive treatment toxicities despite individually reduced doses of methotrexate and cyclophosphamide. However, in the MRI there was no significant reduction in pathologic lymph nodes after three immunochemotherapy courses. Therefore, a lymph node biopsy was taken. Its subsequent histopathological examination revealed tuberculosis-like changes, though tuberculosis suspicion was excluded. After two following immunochemotherapy courses, PET-CT confirmed complete remission. From March 2022 onwards, the patient has remained in remission under the care of the outpatient children's oncology clinic." @default.
- W4313648637 created "2023-01-07" @default.
- W4313648637 creator A5001383078 @default.
- W4313648637 creator A5001980965 @default.
- W4313648637 creator A5007979079 @default.
- W4313648637 creator A5010331268 @default.
- W4313648637 creator A5040864798 @default.
- W4313648637 creator A5051111839 @default.
- W4313648637 creator A5057290346 @default.
- W4313648637 creator A5067194105 @default.
- W4313648637 creator A5068243958 @default.
- W4313648637 creator A5073487699 @default.
- W4313648637 creator A5074387600 @default.
- W4313648637 creator A5074659166 @default.
- W4313648637 creator A5077669051 @default.
- W4313648637 creator A5088275631 @default.
- W4313648637 date "2023-01-06" @default.
- W4313648637 modified "2023-10-17" @default.
- W4313648637 title "Successful Treatment of Large B-Cell Lymphoma in a Child with Compound Heterozygous Mutation in the ATM Gene" @default.
- W4313648637 cites W1502170811 @default.
- W4313648637 cites W1970413157 @default.
- W4313648637 cites W2007025868 @default.
- W4313648637 cites W2021341670 @default.
- W4313648637 cites W2033280158 @default.
- W4313648637 cites W2042524696 @default.
- W4313648637 cites W2045791858 @default.
- W4313648637 cites W2059145105 @default.
- W4313648637 cites W2063437812 @default.
- W4313648637 cites W2069913547 @default.
- W4313648637 cites W2103441770 @default.
- W4313648637 cites W2137518425 @default.
- W4313648637 cites W2142422850 @default.
- W4313648637 cites W2164004777 @default.
- W4313648637 cites W2167837696 @default.
- W4313648637 cites W2174602966 @default.
- W4313648637 cites W2310716991 @default.
- W4313648637 cites W2320983896 @default.
- W4313648637 cites W2520978073 @default.
- W4313648637 cites W2553312780 @default.
- W4313648637 cites W2562282643 @default.
- W4313648637 cites W2805479364 @default.
- W4313648637 cites W2808187259 @default.
- W4313648637 cites W2904262941 @default.
- W4313648637 cites W2910565439 @default.
- W4313648637 cites W2950829931 @default.
- W4313648637 cites W2990138864 @default.
- W4313648637 cites W3014459440 @default.
- W4313648637 cites W3183792933 @default.
- W4313648637 cites W3194830736 @default.
- W4313648637 cites W4224122355 @default.
- W4313648637 cites W4247053599 @default.
- W4313648637 cites W4296173389 @default.
- W4313648637 cites W4306925089 @default.
- W4313648637 cites W4307128712 @default.
- W4313648637 doi "https://doi.org/10.3390/ijms24021099" @default.
- W4313648637 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36674612" @default.
- W4313648637 hasPublicationYear "2023" @default.
- W4313648637 type Work @default.
- W4313648637 citedByCount "2" @default.
- W4313648637 countsByYear W43136486372023 @default.
- W4313648637 crossrefType "journal-article" @default.
- W4313648637 hasAuthorship W4313648637A5001383078 @default.
- W4313648637 hasAuthorship W4313648637A5001980965 @default.
- W4313648637 hasAuthorship W4313648637A5007979079 @default.
- W4313648637 hasAuthorship W4313648637A5010331268 @default.
- W4313648637 hasAuthorship W4313648637A5040864798 @default.
- W4313648637 hasAuthorship W4313648637A5051111839 @default.
- W4313648637 hasAuthorship W4313648637A5057290346 @default.
- W4313648637 hasAuthorship W4313648637A5067194105 @default.
- W4313648637 hasAuthorship W4313648637A5068243958 @default.
- W4313648637 hasAuthorship W4313648637A5073487699 @default.
- W4313648637 hasAuthorship W4313648637A5074387600 @default.
- W4313648637 hasAuthorship W4313648637A5074659166 @default.
- W4313648637 hasAuthorship W4313648637A5077669051 @default.
- W4313648637 hasAuthorship W4313648637A5088275631 @default.
- W4313648637 hasBestOaLocation W43136486371 @default.
- W4313648637 hasConcept C126322002 @default.
- W4313648637 hasConcept C141071460 @default.
- W4313648637 hasConcept C143425029 @default.
- W4313648637 hasConcept C143998085 @default.
- W4313648637 hasConcept C2776694085 @default.
- W4313648637 hasConcept C2776755627 @default.
- W4313648637 hasConcept C2777136964 @default.
- W4313648637 hasConcept C2779338263 @default.
- W4313648637 hasConcept C2779486608 @default.
- W4313648637 hasConcept C2780653079 @default.
- W4313648637 hasConcept C54355233 @default.
- W4313648637 hasConcept C552990157 @default.
- W4313648637 hasConcept C71924100 @default.
- W4313648637 hasConcept C86803240 @default.
- W4313648637 hasConceptScore W4313648637C126322002 @default.
- W4313648637 hasConceptScore W4313648637C141071460 @default.
- W4313648637 hasConceptScore W4313648637C143425029 @default.
- W4313648637 hasConceptScore W4313648637C143998085 @default.
- W4313648637 hasConceptScore W4313648637C2776694085 @default.
- W4313648637 hasConceptScore W4313648637C2776755627 @default.
- W4313648637 hasConceptScore W4313648637C2777136964 @default.
- W4313648637 hasConceptScore W4313648637C2779338263 @default.