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- W4313649320 abstract "Abstract tRip is a tRNA import protein specific to Plasmodium , the causative agent of malaria. In addition to its membrane localization and tRNA trafficking properties, tRip has the capacity to associate with three aminoacyl‐tRNA synthetases (aaRS), the glutamyl‐ (ERS), glutaminyl‐ (QRS), and methionyl‐ (MRS) tRNA synthetases. In eukaryotes, such multi‐aaRSs complexes (MSC) regulate the moonlighting activities of aaRSs. In Plasmodium , tRip and the three aaRSs all contain an N‐terminal GST‐like domain involved in the assembly of two independent complexes: the Q‐complex (tRip:ERS:QRS) and the M‐complex (tRip:ERS:MRS) with a 2:2:2 stoichiometry and in which the association of the GST‐like domains of tRip and ERS (tRip‐N:ERS‐N) is central. In this study, the crystal structure of the N‐terminal GST‐like domain of ERS was solved and made possible further investigation of the solution architecture of the Q‐ and M‐complexes by small‐angle x‐ray scattering (SAXS). This strategy relied on the engineering of a tRip‐N‐ERS‐N chimeric protein to study the structural scaffold of both Plasmodium MSCs and confirm the unique homodimerization pattern of tRip in solution. The biological impact of these structural arrangements is discussed." @default.
- W4313649320 created "2023-01-07" @default.
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- W4313649320 date "2023-01-26" @default.
- W4313649320 modified "2023-10-16" @default.
- W4313649320 title "Solution X‐ray scattering highlights discrepancies in <i>Plasmodium</i><scp>multi‐aminoacyl‐tRNA</scp> synthetase complexes" @default.
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- W4313649320 doi "https://doi.org/10.1002/pro.4564" @default.
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