Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313649743> ?p ?o ?g. }
- W4313649743 abstract "Little is known about the impact of metabolic stimuli on brain tissue at a molecular level. The ketone body beta-hydroxybutyrate (BHB) can be a signaling molecule regulating gene transcription. Thus, we assessed lysine beta-hydroxybutyrylation (K-bhb) levels in proteins extracted from the cerebral cortex of mice undergoing a ketogenic metabolic challenge (48 h fasting). We found that fasting enhanced K-bhb in a variety of proteins including histone H3. ChIP-seq experiments showed that K9 beta-hydroxybutyrylation of H3 (H3K9-bhb) was significantly enriched by fasting on more than 8000 DNA loci. Transcriptomic analysis showed that H3K9-bhb on enhancers and promoters correlated with active gene expression. One of the most enriched functional annotations both at the epigenetic and transcriptional level was circadian rhythms''. Indeed, we found that the diurnal oscillation of specific transcripts was modulated by fasting at distinct zeitgeber times both in the cortex and suprachiasmatic nucleus. Moreover, specific changes in locomotor activity daily features were observed during re-feeding after 48-h fasting. Thus, our results suggest that fasting remarkably impinges on the cerebral cortex transcriptional and epigenetic landscape, and BHB acts as a powerful epigenetic molecule in the brain through direct and specific histone marks remodeling in neural tissue cells." @default.
- W4313649743 created "2023-01-07" @default.
- W4313649743 creator A5011477209 @default.
- W4313649743 creator A5015477036 @default.
- W4313649743 creator A5024963447 @default.
- W4313649743 creator A5033904435 @default.
- W4313649743 creator A5034122039 @default.
- W4313649743 creator A5042393433 @default.
- W4313649743 creator A5042723074 @default.
- W4313649743 creator A5062847907 @default.
- W4313649743 creator A5064556745 @default.
- W4313649743 creator A5069180122 @default.
- W4313649743 creator A5069588422 @default.
- W4313649743 creator A5069978192 @default.
- W4313649743 creator A5079782620 @default.
- W4313649743 creator A5085708799 @default.
- W4313649743 creator A5086045349 @default.
- W4313649743 creator A5088813478 @default.
- W4313649743 date "2023-01-01" @default.
- W4313649743 modified "2023-10-14" @default.
- W4313649743 title "Brain histone beta-hydroxybutyrylation couples metabolism with gene expression" @default.
- W4313649743 cites W1488128045 @default.
- W4313649743 cites W1593725384 @default.
- W4313649743 cites W1966556786 @default.
- W4313649743 cites W1972899801 @default.
- W4313649743 cites W1974633668 @default.
- W4313649743 cites W1974753375 @default.
- W4313649743 cites W2000952305 @default.
- W4313649743 cites W2001107975 @default.
- W4313649743 cites W2028719532 @default.
- W4313649743 cites W2033720614 @default.
- W4313649743 cites W2034312395 @default.
- W4313649743 cites W2035519364 @default.
- W4313649743 cites W2036551825 @default.
- W4313649743 cites W2053465680 @default.
- W4313649743 cites W2064756496 @default.
- W4313649743 cites W2073742199 @default.
- W4313649743 cites W2074778604 @default.
- W4313649743 cites W2086482588 @default.
- W4313649743 cites W2091187766 @default.
- W4313649743 cites W2099614676 @default.
- W4313649743 cites W2112220625 @default.
- W4313649743 cites W2118612617 @default.
- W4313649743 cites W2119754857 @default.
- W4313649743 cites W2121226849 @default.
- W4313649743 cites W2125222784 @default.
- W4313649743 cites W2133727193 @default.
- W4313649743 cites W2136503478 @default.
- W4313649743 cites W2140815401 @default.
- W4313649743 cites W2144227498 @default.
- W4313649743 cites W2151770308 @default.
- W4313649743 cites W2157201312 @default.
- W4313649743 cites W2158025896 @default.
- W4313649743 cites W2166901713 @default.
- W4313649743 cites W2205259970 @default.
- W4313649743 cites W2217409635 @default.
- W4313649743 cites W2249258034 @default.
- W4313649743 cites W2337350186 @default.
- W4313649743 cites W2411915694 @default.
- W4313649743 cites W2501106982 @default.
- W4313649743 cites W2510681644 @default.
- W4313649743 cites W2527551486 @default.
- W4313649743 cites W2577334379 @default.
- W4313649743 cites W2592762648 @default.
- W4313649743 cites W2600940396 @default.
- W4313649743 cites W2605620508 @default.
- W4313649743 cites W2621268123 @default.
- W4313649743 cites W2740286558 @default.
- W4313649743 cites W2751357806 @default.
- W4313649743 cites W2766888606 @default.
- W4313649743 cites W2773526606 @default.
- W4313649743 cites W2783535973 @default.
- W4313649743 cites W2905460695 @default.
- W4313649743 cites W2950534106 @default.
- W4313649743 cites W2952477531 @default.
- W4313649743 cites W2957519155 @default.
- W4313649743 cites W3010445821 @default.
- W4313649743 cites W3038249509 @default.
- W4313649743 cites W3043859478 @default.
- W4313649743 cites W3098002325 @default.
- W4313649743 cites W3129905153 @default.
- W4313649743 cites W3131093652 @default.
- W4313649743 cites W3161198325 @default.
- W4313649743 cites W3164891794 @default.
- W4313649743 cites W3188662067 @default.
- W4313649743 cites W3199251326 @default.
- W4313649743 cites W3212548298 @default.
- W4313649743 cites W4213062594 @default.
- W4313649743 cites W4213365625 @default.
- W4313649743 cites W4225359199 @default.
- W4313649743 cites W57176434 @default.
- W4313649743 doi "https://doi.org/10.1007/s00018-022-04673-9" @default.
- W4313649743 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36607453" @default.
- W4313649743 hasPublicationYear "2023" @default.
- W4313649743 type Work @default.
- W4313649743 citedByCount "5" @default.
- W4313649743 countsByYear W43136497432023 @default.
- W4313649743 crossrefType "journal-article" @default.
- W4313649743 hasAuthorship W4313649743A5011477209 @default.
- W4313649743 hasAuthorship W4313649743A5015477036 @default.