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• W4313649991 abstract "Although radiotherapy is one of the most common treatments for triple-negative breast cancer (TNBC), it frequently has unsatisfactory therapeutic outcomes due to the radiation resistance of tumor tissues. Therefore, a synergistic strategy is urgently needed to increase therapeutic responses and prolong patient survival. Herein, we constructed gold nanocages (GNCs) loaded with a hyperpyrexia-sensitive nitric oxide (NO) donor (thiolate cupferron) to integrate extrinsic radiosensitization, local photothermal therapy, and near-infrared-activated NO gas therapy. The resulting nanoplatform (GNCs@NO) showed a high photothermal conversion efficiency, which induced the death of cancer cells and facilitated rapid NO release in tumor tissues. The radiosensitizing efficacy of GNCs@NO was further demonstrated in vitro and in vivo. Importantly, the released NO reacted with the reactive oxide species induced by radiotherapy to produce more toxic reactive nitrogen species, exerting a synergistic effect to improve anticancer efficacy. Thus, GNCs@NO demonstrated excellent effects as a combination therapy with few adverse effects. Our work proposes a promising nanoplatform for the radio/photothermal/gas treatment of TNBC." @default.
• W4313649991 created "2023-01-07" @default.
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• W4313649991 date "2023-01-06" @default.
• W4313649991 modified "2023-09-30" @default.
• W4313649991 title "Gold nanoplatform for near-infrared light-activated radio-photothermal gas therapy in breast cancer" @default.
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• W4313649991 doi "https://doi.org/10.3389/fbioe.2022.1098986" @default.
• W4313649991 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36686245" @default.
• W4313649991 hasPublicationYear "2023" @default.
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