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• W4313650424 abstract "Chemical constituent investigation on the n-BuOH extract of the rhizomes of Tupistra chinensis Baker leads to the isolation of ten compounds including eight undescribed furostanol saponins, tupischinosides A − H, and two known ones. The structures of isolated compounds were determined by extensive spectral analysis and chemical evidences. Interestingly, tupischinosides A and B, C and D, E and F, G and H were identified as four pairs of epimers. The cytotoxicity of tupischinosides A − H against human cancer cell lines U87, SHG44, U251, LN229 and HepG-2 was evaluated by CCK-8 method. As a result, tupischinosides A and C exhibited significant proliferation inhibitory effect on the tested cancer cells. On the contrary, the corresponding epimers, tupischinosides B and D, which only differ in the configuration of C-23 didn't exhibit any cytotoxicity to cancer cells. These results indicated that the stereochemistry of C-23 was crucial to the activity of the compounds." @default.
• W4313650424 created "2023-01-07" @default.
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• W4313650424 date "2023-03-01" @default.
• W4313650424 modified "2023-09-28" @default.
• W4313650424 title "Steriodal saponins from the rhizomes of Tupistra chinensis Baker" @default.
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• W4313650424 doi "https://doi.org/10.1016/j.phytochem.2022.113583" @default.
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