FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313650442> ?p ?o ?g. }

• W4313650442 abstract "Abstract Peritoneal metastasis (PM) is the most common form of distant metastasis and one of the leading causes of death in gastric cancer (GC). For locally advanced GC, clinical guidelines recommend peritoneal lavage cytology for intraoperative PM detection. Unfortunately, current peritoneal lavage cytology is limited by low sensitivity (<60%). Here we established the stimulated Raman cytology (SRC), a chemical microscopy-based intelligent cytology. By taking advantages of stimulated Raman scattering in label-free, high-speed, and high-resolution chemical imaging, we firstly imaged 53951 exfoliated cells in ascites obtained from 80 GC patients (27 PM positive, 53 PM negative), at the Raman bands corresponding to DNA, protein, and lipid, respectively. Then, we revealed 12 single cell features of morphology and composition that were significantly different between PM positive and negative specimens, including cellular area, lipid protein ratio, etc. Importantly, we developed a single cell phenotyping algorithm to further transform the above raw features to feature matrix. Such matrix was crucial to identify the significant marker cell cluster, the divergence of which was finally used to differentiate the PM positive and negative. Compared with histopathology, the gold standard of PM detection, our SRC method assisted by machine learning classifiers could reach 81.5% sensitivity, 84.9% specificity, and the area under receiver operating characteristic curve of 0.85, within 20 minutes for each patient. Such remarkable improvement in detection accuracy is largely owing to incorporation of the single-cell composition features in SRC. Together, our SRC method shows great potential for accurate and rapid detection of PM from GC." @default.
• W4313650442 created "2023-01-07" @default.
• W4313650442 creator A5015195367 @default.
• W4313650442 creator A5016612020 @default.
• W4313650442 creator A5027183987 @default.
• W4313650442 creator A5031049292 @default.
• W4313650442 creator A5040899817 @default.
• W4313650442 creator A5042028235 @default.
• W4313650442 creator A5056773566 @default.
• W4313650442 creator A5064149981 @default.
• W4313650442 creator A5075640750 @default.
• W4313650442 creator A5079139864 @default.
• W4313650442 creator A5079618096 @default.
• W4313650442 creator A5083857025 @default.
• W4313650442 creator A5084407437 @default.
• W4313650442 creator A5091003078 @default.
• W4313650442 date "2023-01-06" @default.
• W4313650442 modified "2023-09-27" @default.
• W4313650442 title "Accurate and Rapid Detection of Peritoneal Metastasis from Gastric Cancer by AI-assisted Stimulated Raman Cytology" @default.
• W4313650442 cites W1800533986 @default.
• W4313650442 cites W1917177382 @default.
• W4313650442 cites W1966921871 @default.
• W4313650442 cites W2007061128 @default.
• W4313650442 cites W2011257306 @default.
• W4313650442 cites W2022399992 @default.
• W4313650442 cites W2025606755 @default.
• W4313650442 cites W2046218036 @default.
• W4313650442 cites W2050852571 @default.
• W4313650442 cites W2070603704 @default.
• W4313650442 cites W2076346713 @default.
• W4313650442 cites W2090360382 @default.
• W4313650442 cites W2103218646 @default.
• W4313650442 cites W2108576479 @default.
• W4313650442 cites W2121145790 @default.
• W4313650442 cites W2124242050 @default.
• W4313650442 cites W2166397319 @default.
• W4313650442 cites W2246448980 @default.
• W4313650442 cites W2332583381 @default.
• W4313650442 cites W2392336814 @default.
• W4313650442 cites W2570422826 @default.
• W4313650442 cites W2594627604 @default.
• W4313650442 cites W2605552373 @default.
• W4313650442 cites W2606111706 @default.
• W4313650442 cites W2618080549 @default.
• W4313650442 cites W2783299847 @default.
• W4313650442 cites W2923791081 @default.
• W4313650442 cites W2939928699 @default.
• W4313650442 cites W2956046890 @default.
• W4313650442 cites W2963444747 @default.
• W4313650442 cites W2980415926 @default.
• W4313650442 cites W2998401461 @default.
• W4313650442 cites W3000622796 @default.
• W4313650442 cites W3007853760 @default.
• W4313650442 cites W3045423502 @default.
• W4313650442 cites W3047583202 @default.
• W4313650442 cites W3121611509 @default.
• W4313650442 cites W3122411340 @default.
• W4313650442 cites W3128646645 @default.
• W4313650442 cites W3157598024 @default.
• W4313650442 cites W3172733547 @default.
• W4313650442 cites W3173096232 @default.
• W4313650442 cites W4205285776 @default.
• W4313650442 cites W4205653278 @default.
• W4313650442 cites W4206487992 @default.
• W4313650442 cites W4210511445 @default.
• W4313650442 cites W4211066405 @default.
• W4313650442 cites W4211130279 @default.
• W4313650442 cites W4220798004 @default.
• W4313650442 cites W4234323433 @default.
• W4313650442 cites W4250948394 @default.
• W4313650442 cites W4282925178 @default.
• W4313650442 cites W4285392824 @default.
• W4313650442 doi "https://doi.org/10.1101/2023.01.05.522829" @default.
• W4313650442 hasPublicationYear "2023" @default.
• W4313650442 type Work @default.
• W4313650442 citedByCount "0" @default.
• W4313650442 crossrefType "posted-content" @default.
• W4313650442 hasAuthorship W4313650442A5015195367 @default.
• W4313650442 hasAuthorship W4313650442A5016612020 @default.
• W4313650442 hasAuthorship W4313650442A5027183987 @default.
• W4313650442 hasAuthorship W4313650442A5031049292 @default.
• W4313650442 hasAuthorship W4313650442A5040899817 @default.
• W4313650442 hasAuthorship W4313650442A5042028235 @default.
• W4313650442 hasAuthorship W4313650442A5056773566 @default.
• W4313650442 hasAuthorship W4313650442A5064149981 @default.
• W4313650442 hasAuthorship W4313650442A5075640750 @default.
• W4313650442 hasAuthorship W4313650442A5079139864 @default.
• W4313650442 hasAuthorship W4313650442A5079618096 @default.
• W4313650442 hasAuthorship W4313650442A5083857025 @default.
• W4313650442 hasAuthorship W4313650442A5084407437 @default.
• W4313650442 hasAuthorship W4313650442A5091003078 @default.
• W4313650442 hasBestOaLocation W43136504421 @default.
• W4313650442 hasConcept C121608353 @default.
• W4313650442 hasConcept C126322002 @default.
• W4313650442 hasConcept C126838900 @default.
• W4313650442 hasConcept C142724271 @default.
• W4313650442 hasConcept C18823058 @default.
• W4313650442 hasConcept C2779013556 @default.
• W4313650442 hasConcept C2780496750 @default.
• W4313650442 hasConcept C2989005 @default.

• next