Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313650737> ?p ?o ?g. }
- W4313650737 endingPage "118" @default.
- W4313650737 startingPage "112" @default.
- W4313650737 abstract "Purpose of review Several plasma biomarkers for Alzheimer's disease and related disorders (ADRD) have demonstrated clinical and technical robustness. However, are they ready for clinical implementation? This review critically appraises current evidence for and against the immediate use of plasma biomarkers in clinical care. Recent findings Plasma biomarkers have significantly improved our understanding of ADRD time-course, risk factors, diagnosis and prognosis. These advances are accelerating the development and in-human testing of therapeutic candidates, and the selection of individuals with subtle biological evidence of disease who fit the criteria for early therapeutic targeting. However, standardized tests and well validated cut-off values are lacking. Moreover, some assays (e.g., plasma Aβ methods) have poor robustness to withstand inevitable day-to-day technical variations. Additionally, recent reports suggest that common comorbidities of aging (e.g., kidney disease, diabetes, hypertension) can erroneously affect plasma biomarker levels, clinical utility and generalizability. Furthermore, it is unclear if health disparities can explain reported racial/ethnic differences in biomarker levels and functions. Finally, current clinically approved plasma methods are more expensive than CSF assays, questioning their cost effectiveness. Summary Plasma biomarkers have biological and clinical capacity to detect ADRD. However, their widespread use requires issues around thresholds, comorbidities and diverse populations to be addressed." @default.
- W4313650737 created "2023-01-07" @default.
- W4313650737 creator A5025313057 @default.
- W4313650737 creator A5053530106 @default.
- W4313650737 creator A5061106273 @default.
- W4313650737 creator A5079766290 @default.
- W4313650737 date "2023-01-16" @default.
- W4313650737 modified "2023-10-02" @default.
- W4313650737 title "Plasma biomarkers for neurodegenerative disorders: ready for prime time?" @default.
- W4313650737 cites W1496642521 @default.
- W4313650737 cites W2115821900 @default.
- W4313650737 cites W2142315671 @default.
- W4313650737 cites W2587240044 @default.
- W4313650737 cites W2600914407 @default.
- W4313650737 cites W2785757836 @default.
- W4313650737 cites W2798054687 @default.
- W4313650737 cites W2894413318 @default.
- W4313650737 cites W2900137947 @default.
- W4313650737 cites W2909871453 @default.
- W4313650737 cites W2917353757 @default.
- W4313650737 cites W2938221890 @default.
- W4313650737 cites W2939789416 @default.
- W4313650737 cites W2949225738 @default.
- W4313650737 cites W2966365568 @default.
- W4313650737 cites W2967878847 @default.
- W4313650737 cites W2981311909 @default.
- W4313650737 cites W2984229501 @default.
- W4313650737 cites W2990944800 @default.
- W4313650737 cites W3018431352 @default.
- W4313650737 cites W3042257464 @default.
- W4313650737 cites W3042931334 @default.
- W4313650737 cites W3044633524 @default.
- W4313650737 cites W3045997188 @default.
- W4313650737 cites W3049719602 @default.
- W4313650737 cites W3093943691 @default.
- W4313650737 cites W3106880531 @default.
- W4313650737 cites W3107511586 @default.
- W4313650737 cites W3108081750 @default.
- W4313650737 cites W3119309452 @default.
- W4313650737 cites W3131174931 @default.
- W4313650737 cites W3133060003 @default.
- W4313650737 cites W3135004658 @default.
- W4313650737 cites W3159530258 @default.
- W4313650737 cites W3161967669 @default.
- W4313650737 cites W3165219122 @default.
- W4313650737 cites W3167068736 @default.
- W4313650737 cites W3172679834 @default.
- W4313650737 cites W3176477588 @default.
- W4313650737 cites W3181997110 @default.
- W4313650737 cites W3182597378 @default.
- W4313650737 cites W3182927843 @default.
- W4313650737 cites W3199026337 @default.
- W4313650737 cites W3203949179 @default.
- W4313650737 cites W3206837711 @default.
- W4313650737 cites W3214993261 @default.
- W4313650737 cites W4206179494 @default.
- W4313650737 cites W4210357094 @default.
- W4313650737 cites W4213423501 @default.
- W4313650737 cites W4224321671 @default.
- W4313650737 cites W4225303432 @default.
- W4313650737 cites W4225589542 @default.
- W4313650737 cites W4280490458 @default.
- W4313650737 cites W4281558685 @default.
- W4313650737 cites W4291020647 @default.
- W4313650737 cites W4294876597 @default.
- W4313650737 cites W4295693891 @default.
- W4313650737 cites W4308963383 @default.
- W4313650737 cites W4310603866 @default.
- W4313650737 doi "https://doi.org/10.1097/yco.0000000000000851" @default.
- W4313650737 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36607770" @default.
- W4313650737 hasPublicationYear "2023" @default.
- W4313650737 type Work @default.
- W4313650737 citedByCount "4" @default.
- W4313650737 countsByYear W43136507372023 @default.
- W4313650737 crossrefType "journal-article" @default.
- W4313650737 hasAuthorship W4313650737A5025313057 @default.
- W4313650737 hasAuthorship W4313650737A5053530106 @default.
- W4313650737 hasAuthorship W4313650737A5061106273 @default.
- W4313650737 hasAuthorship W4313650737A5079766290 @default.
- W4313650737 hasBestOaLocation W43136507371 @default.
- W4313650737 hasConcept C104317684 @default.
- W4313650737 hasConcept C124535831 @default.
- W4313650737 hasConcept C126322002 @default.
- W4313650737 hasConcept C134018914 @default.
- W4313650737 hasConcept C138496976 @default.
- W4313650737 hasConcept C15744967 @default.
- W4313650737 hasConcept C177713679 @default.
- W4313650737 hasConcept C27158222 @default.
- W4313650737 hasConcept C2779134260 @default.
- W4313650737 hasConcept C2781197716 @default.
- W4313650737 hasConcept C46111723 @default.
- W4313650737 hasConcept C55493867 @default.
- W4313650737 hasConcept C555293320 @default.
- W4313650737 hasConcept C60644358 @default.
- W4313650737 hasConcept C71924100 @default.
- W4313650737 hasConcept C86803240 @default.
- W4313650737 hasConceptScore W4313650737C104317684 @default.
- W4313650737 hasConceptScore W4313650737C124535831 @default.