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- W4313650892 abstract "Abstract Ion channels of the DEG/ENaC family share a similar structure but serve strikingly diverse biological functions, such as Na + reabsorption, mechanosensing, proton-sensing, chemosensing and cell-cell communication via neuropeptides. This functional diversity raises the question of the ancient function of DEG/ENaCs. Using an extensive phylogenetic analysis across many different animal groups, we found a surprising diversity of DEG/ENaCs already in Cnidaria (corals, sea anemones, hydroids and jellyfish). Using a combination of gene expression analysis, electrophysiological and functional studies combined with pharmacological inhibition as well as genetic knockout in the model cnidarian Nematostella vectensis , we reveal an unanticipated role for a proton-sensitive DEG/ENaC in discharge of N. vectensis cnidocytes, the stinging cells typifying all cnidarians. Our study supports the view that DEG/ENaCs are versatile channels that have been co-opted for diverse functions since their early occurrence in animals and that respond to simple and ancient stimuli, such as omnipresent protons." @default.
- W4313650892 created "2023-01-07" @default.
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- W4313650892 date "2023-01-06" @default.
- W4313650892 modified "2023-10-18" @default.
- W4313650892 title "Functional analysis in a model sea anemone reveals phylogenetic complexity and a role in cnidocyte discharge of DEG/ENaC ion channels" @default.
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- W4313650892 doi "https://doi.org/10.1038/s42003-022-04399-1" @default.
- W4313650892 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36609696" @default.
- W4313650892 hasPublicationYear "2023" @default.
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