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• W4313652556 endingPage "102881" @default.
• W4313652556 startingPage "102881" @default.
• W4313652556 abstract "Mutations in genes involved in mitochondrial proline catabolism lead to the rare genetic disorder hyperprolinemia in humans. We have previously reported that mutations of proline catabolic genes in Caenorhabditis elegans impair mitochondrial homeostasis and shorten life span, and that these effects surprisingly occur in a diet type-dependent manner. Therefore, we speculated that a specific dietary component may mitigate the adverse effects of defective proline catabolism. Here, we discovered that high dietary glucose, which is generally detrimental to health, actually improves mitochondrial homeostasis and life span in C. elegans with faulty proline catabolism. Mechanistically, defective proline catabolism results in a shift of glucose catabolism toward the pentose phosphate pathway, which is crucial for cellular redox balance. This shift helps to maintain mitochondrial reactive oxygen species homeostasis and to extend life span, as suppression of the pentose phosphate pathway enzyme GSPD-1 prevents the favorable effects of high glucose. In addition, we demonstrate that this crosstalk between proline and glucose catabolism is mediated by the transcription factor DAF-16. Altogether, these findings suggest that a glucose-rich diet may be advantageous in certain situations and might represent a potentially viable treatment strategy for disorders involving impaired proline catabolism." @default.
• W4313652556 created "2023-01-07" @default.
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• W4313652556 date "2023-02-01" @default.
• W4313652556 modified "2023-10-17" @default.
• W4313652556 title "The impact of glucose on mitochondria and life span is determined by the integrity of proline catabolism in Caenorhabditis elegans" @default.
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• W4313652556 doi "https://doi.org/10.1016/j.jbc.2023.102881" @default.
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• W4313652556 hasPublicationYear "2023" @default.
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