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• W4313654094 abstract "Thyroid hormone receptors (TRs) are cellular homologues of the viral erythroblastic leukemia oncogene (v-erbA). TRs (c-crbA isoforms) are derived from two separate gene loci in mammals: a and p. Through a series of knockout experiments in mice in which one or several of the TR isoforms were deleted, it has been demonstrated that the TR-β isoforms control central regulation of thyroid-stimulating hormone. Of these isoforms, TR-β2 is the most important in mediating negative feedback control of the hypothalamic-pituitary-thyroid axis. Further analysis of TR knockout animals revealed, however, that they exhibited a much milder overall phenotype than hypothyroid animals, indicating that receptor loss was not equivalent to ligand loss in vivo. To understand this apparent paradox, we generated animals expressing a non-T 3 binding receptor (Δ337T) from the TR-β allele. These mice displayed a complete hypothyroid phenotype, demonstrating that the unliganded TR mediates the effect of hypothyroidism. Because this mutant TR constitutively binds to nuclear coreprssors, it also suggests that this class of proteins is essential for mediating hypothyroidism in vivo." @default.
• W4313654094 created "2023-01-07" @default.
• W4313654094 creator A5049313563 @default.
• W4313654094 date "2003-07-01" @default.
• W4313654094 modified "2023-09-27" @default.
• W4313654094 title "Thyroid Hormone Action: Insight from Transgenic Mouse Models" @default.
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• W4313654094 doi "https://doi.org/10.1177/108155890305100422" @default.
• W4313654094 hasPublicationYear "2003" @default.
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