Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313655672> ?p ?o ?g. }
- W4313655672 endingPage "100860" @default.
- W4313655672 startingPage "100860" @default.
- W4313655672 abstract "Prenatal antibiotic use, the ensuing maternal dysbiosis, and subsequent acquisition of altered microbiota in early life have been linked to the offspring's increased susceptibility to childhood infections. However, infection risks during the first year of life associated with in-utero antibiotic exposure have not been comprehensively explored.To investigate the associations between exposure to antibiotics in utero and subsequent infections during infancy and whether such associations differ by antibiotic class.All data were retrieved from Swedish population-based registers. Singletons live-born between 2006 and 2018 were followed up from birth to their first birthday. Exposure was maternal filling of at least 1 antibiotic prescription between the last menstrual period and delivery. Outcomes were the infants' antimicrobial prescription fills, incident infections diagnosed in specialist care, and deaths with infections indicated as underlying or contributing causes (infection-related deaths). Birth year, birth season, maternal age, place of residence, parity, comorbidity indicator, body mass index, proxies for general health status, education level, and smoking status were considered covariates. Poisson regression was used to estimate crude and adjusted incidence rate ratios with 95% confidence intervals for the number of antimicrobial prescriptions filled to the infant. Cox regression was used to estimate crude and adjusted hazard ratios with 95% confidence intervals for incident infections diagnosed in specialist care and at death. Sibling analyses were used to account for shared familial factors. Sensitivity of the results to exposure definition and perinatal factors prognostic for the outcomes were assessed in supplementary analyses.Of 1,347,018 infants in the full cohort, 294,657 (21.9%) were exposed to antibiotics in utero. There were 677,430 antimicrobial prescriptions filled (1.380 per 1000 person-days), 423,705 incident infections diagnosed in specialist care (0.870 per 1000 person-days), and 2800 infection-related deaths (0.006 deaths per 1000 person-days) during follow-up. Compared to unexposed, infants exposed to antibiotics in utero had higher rates of antimicrobial prescription fills (adjusted incidence rate ratio, 1.34; 95% confidence interval, 1.33-1.34), incident infections diagnosed in specialist care (adjusted hazard ratio, 1.28; 95% confidence interval, 1.27-1.29), and infection-related mortality (adjusted hazard ratio, 1.15; 95% confidence interval, 1.05-1.25). For antimicrobial prescriptions and infections diagnosed in specialist care, associations were consistent across most antibiotic classes but were attenuated in the sibling analyses: adjusted incidence rate ratio of 1.05 (95% confidence interval, 1.04-1.06) and adjusted hazard ratio of 1.05 (95% confidence interval, 1.03-1.07), respectively. No association with infant mortality was found in the sibling cohort (adjusted hazard ratio, 0.93; 95% confidence interval, 0.81-1.08).The minor associations between exposure to antibiotics in utero and infections during infancy were partly explained by shared familial factors and did not differ across frequently used antibiotic classes." @default.
- W4313655672 created "2023-01-07" @default.
- W4313655672 creator A5036689538 @default.
- W4313655672 creator A5045904952 @default.
- W4313655672 creator A5051409156 @default.
- W4313655672 creator A5063723476 @default.
- W4313655672 creator A5072660677 @default.
- W4313655672 creator A5078317555 @default.
- W4313655672 creator A5091000367 @default.
- W4313655672 date "2023-04-01" @default.
- W4313655672 modified "2023-09-30" @default.
- W4313655672 title "In-utero antibiotic exposure and subsequent infections in infancy: a register-based cohort study with sibling analysis" @default.
- W4313655672 cites W1528668937 @default.
- W4313655672 cites W1831022746 @default.
- W4313655672 cites W1981820813 @default.
- W4313655672 cites W1996992398 @default.
- W4313655672 cites W2043188455 @default.
- W4313655672 cites W2047751481 @default.
- W4313655672 cites W2049623777 @default.
- W4313655672 cites W2052768718 @default.
- W4313655672 cites W2053439854 @default.
- W4313655672 cites W2070879762 @default.
- W4313655672 cites W2116953657 @default.
- W4313655672 cites W2141761576 @default.
- W4313655672 cites W2143264843 @default.
- W4313655672 cites W2150180906 @default.
- W4313655672 cites W2166018731 @default.
- W4313655672 cites W2168021466 @default.
- W4313655672 cites W2175341273 @default.
- W4313655672 cites W2233885014 @default.
- W4313655672 cites W2320251182 @default.
- W4313655672 cites W2477522410 @default.
- W4313655672 cites W2577967059 @default.
- W4313655672 cites W2762467945 @default.
- W4313655672 cites W2766972239 @default.
- W4313655672 cites W2787311262 @default.
- W4313655672 cites W2809045992 @default.
- W4313655672 cites W2891454985 @default.
- W4313655672 cites W2913598481 @default.
- W4313655672 cites W2934791458 @default.
- W4313655672 cites W2955688011 @default.
- W4313655672 cites W2958673378 @default.
- W4313655672 cites W2973821866 @default.
- W4313655672 cites W3023409205 @default.
- W4313655672 cites W3081154758 @default.
- W4313655672 cites W3092849554 @default.
- W4313655672 cites W3158339579 @default.
- W4313655672 cites W3163532917 @default.
- W4313655672 cites W3185099007 @default.
- W4313655672 cites W4200583185 @default.
- W4313655672 doi "https://doi.org/10.1016/j.ajogmf.2023.100860" @default.
- W4313655672 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36626967" @default.
- W4313655672 hasPublicationYear "2023" @default.
- W4313655672 type Work @default.
- W4313655672 citedByCount "2" @default.
- W4313655672 countsByYear W43136556722023 @default.
- W4313655672 crossrefType "journal-article" @default.
- W4313655672 hasAuthorship W4313655672A5036689538 @default.
- W4313655672 hasAuthorship W4313655672A5045904952 @default.
- W4313655672 hasAuthorship W4313655672A5051409156 @default.
- W4313655672 hasAuthorship W4313655672A5063723476 @default.
- W4313655672 hasAuthorship W4313655672A5072660677 @default.
- W4313655672 hasAuthorship W4313655672A5078317555 @default.
- W4313655672 hasAuthorship W4313655672A5091000367 @default.
- W4313655672 hasBestOaLocation W43136556721 @default.
- W4313655672 hasConcept C126322002 @default.
- W4313655672 hasConcept C138496976 @default.
- W4313655672 hasConcept C144024400 @default.
- W4313655672 hasConcept C149923435 @default.
- W4313655672 hasConcept C15744967 @default.
- W4313655672 hasConcept C167704817 @default.
- W4313655672 hasConcept C187212893 @default.
- W4313655672 hasConcept C201903717 @default.
- W4313655672 hasConcept C207103383 @default.
- W4313655672 hasConcept C2776194465 @default.
- W4313655672 hasConcept C2779234561 @default.
- W4313655672 hasConcept C2908647359 @default.
- W4313655672 hasConcept C44249647 @default.
- W4313655672 hasConcept C50382708 @default.
- W4313655672 hasConcept C54355233 @default.
- W4313655672 hasConcept C71924100 @default.
- W4313655672 hasConcept C72563966 @default.
- W4313655672 hasConcept C73269764 @default.
- W4313655672 hasConcept C86803240 @default.
- W4313655672 hasConcept C99454951 @default.
- W4313655672 hasConceptScore W4313655672C126322002 @default.
- W4313655672 hasConceptScore W4313655672C138496976 @default.
- W4313655672 hasConceptScore W4313655672C144024400 @default.
- W4313655672 hasConceptScore W4313655672C149923435 @default.
- W4313655672 hasConceptScore W4313655672C15744967 @default.
- W4313655672 hasConceptScore W4313655672C167704817 @default.
- W4313655672 hasConceptScore W4313655672C187212893 @default.
- W4313655672 hasConceptScore W4313655672C201903717 @default.
- W4313655672 hasConceptScore W4313655672C207103383 @default.
- W4313655672 hasConceptScore W4313655672C2776194465 @default.
- W4313655672 hasConceptScore W4313655672C2779234561 @default.
- W4313655672 hasConceptScore W4313655672C2908647359 @default.
- W4313655672 hasConceptScore W4313655672C44249647 @default.