FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313656208> ?p ?o ?g. }

• W4313656208 abstract "Abstract Background Frontotemporal dementia (FTD) phenotypes are classically associated with distinctive cortical atrophy patterns and regional hypometabolism. However, the spectrum of cognitive and behavioral manifestations in FTD arises from multisynaptic network dysfunction. The thalamus is a key hub of several corticobasal and corticocortical circuits. The main circuits relayed via the thalamic nuclei include the dorsolateral prefrontal circuit, the anterior cingulate circuit, and the orbitofrontal circuit. Methods In this paper, we have reviewed evidence for thalamic pathology in FTD based on radiological and postmortem studies. Original research papers were systematically reviewed for preferential involvement of specific thalamic regions, for phenotype‐associated thalamic disease burden patterns, characteristic longitudinal changes, and genotype‐associated thalamic signatures. Moreover, evidence for presymptomatic thalamic pathology was also reviewed. Identified papers were systematically scrutinized for imaging methods, cohort sizes, clinical profiles, clinicoradiological associations, and main anatomical findings. The findings of individual research papers were amalgamated for consensus observations and their study designs further evaluated for stereotyped shortcomings. Based on the limitations of existing studies and conflicting reports in low‐incidence FTD variants, we sought to outline future research directions and pressing research priorities. Results FTD is associated with focal thalamic degeneration. Phenotype‐specific thalamic traits mirror established cortical vulnerability patterns. Thalamic nuclei mediating behavioral and language functions are preferentially involved. Given the compelling evidence for considerable thalamic disease burden early in the course of most FTD subtypes, we also reflect on the practical relevance, diagnostic role, prognostic significance, and monitoring potential of thalamic metrics in FTD. Conclusions Cardinal manifestations of FTD phenotypes are likely to stem from thalamocortical circuitry dysfunction and are not exclusively driven by focal cortical changes." @default.
• W4313656208 created "2023-01-07" @default.
• W4313656208 creator A5031666850 @default.
• W4313656208 creator A5057078027 @default.
• W4313656208 creator A5059228379 @default.
• W4313656208 creator A5083816297 @default.
• W4313656208 date "2023-01-07" @default.
• W4313656208 modified "2023-10-04" @default.
• W4313656208 title "Thalamic pathology in frontotemporal dementia: Predilection for specific nuclei, phenotype‐specific signatures, clinical correlates, and practical relevance" @default.
• W4313656208 cites W1525938031 @default.
• W4313656208 cites W1599493014 @default.
• W4313656208 cites W1823618591 @default.
• W4313656208 cites W1893585873 @default.
• W4313656208 cites W1919284595 @default.
• W4313656208 cites W1932510543 @default.
• W4313656208 cites W1944065075 @default.
• W4313656208 cites W1964188390 @default.
• W4313656208 cites W1967914888 @default.
• W4313656208 cites W1983850763 @default.
• W4313656208 cites W1985495481 @default.
• W4313656208 cites W1986986092 @default.
• W4313656208 cites W1987643907 @default.
• W4313656208 cites W1987906186 @default.
• W4313656208 cites W1990438734 @default.
• W4313656208 cites W1995733295 @default.
• W4313656208 cites W1996695464 @default.
• W4313656208 cites W2002632820 @default.
• W4313656208 cites W2002996081 @default.
• W4313656208 cites W2003067498 @default.
• W4313656208 cites W2004222997 @default.
• W4313656208 cites W2008224363 @default.
• W4313656208 cites W2017182954 @default.
• W4313656208 cites W2021401325 @default.
• W4313656208 cites W2025336623 @default.
• W4313656208 cites W2027228825 @default.
• W4313656208 cites W2029881982 @default.
• W4313656208 cites W2033793704 @default.
• W4313656208 cites W2034410483 @default.
• W4313656208 cites W2034416540 @default.
• W4313656208 cites W2035586497 @default.
• W4313656208 cites W2039124066 @default.
• W4313656208 cites W2043242347 @default.
• W4313656208 cites W2043533588 @default.
• W4313656208 cites W2047054588 @default.
• W4313656208 cites W2067772208 @default.
• W4313656208 cites W2068045402 @default.
• W4313656208 cites W2069443367 @default.
• W4313656208 cites W2086909552 @default.
• W4313656208 cites W2089386742 @default.
• W4313656208 cites W2089940272 @default.
• W4313656208 cites W2090365926 @default.
• W4313656208 cites W2095798723 @default.
• W4313656208 cites W2101334128 @default.
• W4313656208 cites W2106786486 @default.
• W4313656208 cites W2110348933 @default.
• W4313656208 cites W2116136260 @default.
• W4313656208 cites W2116658855 @default.
• W4313656208 cites W2116908654 @default.
• W4313656208 cites W2117920021 @default.
• W4313656208 cites W2124540951 @default.
• W4313656208 cites W2127354165 @default.
• W4313656208 cites W2129004139 @default.
• W4313656208 cites W2129658133 @default.
• W4313656208 cites W2131504507 @default.
• W4313656208 cites W2144765528 @default.
• W4313656208 cites W2146088791 @default.
• W4313656208 cites W2154223956 @default.
• W4313656208 cites W2159781745 @default.
• W4313656208 cites W2162496260 @default.
• W4313656208 cites W2163333989 @default.
• W4313656208 cites W2168561180 @default.
• W4313656208 cites W2170087857 @default.
• W4313656208 cites W2170632697 @default.
• W4313656208 cites W2171884247 @default.
• W4313656208 cites W2174491776 @default.
• W4313656208 cites W2176830446 @default.
• W4313656208 cites W2225078867 @default.
• W4313656208 cites W2261269839 @default.
• W4313656208 cites W2262227503 @default.
• W4313656208 cites W2300806746 @default.
• W4313656208 cites W2309633614 @default.
• W4313656208 cites W2345680560 @default.
• W4313656208 cites W2504386017 @default.
• W4313656208 cites W2506919437 @default.
• W4313656208 cites W2507800877 @default.
• W4313656208 cites W2513933507 @default.
• W4313656208 cites W2534857558 @default.
• W4313656208 cites W2535439450 @default.
• W4313656208 cites W2549199021 @default.
• W4313656208 cites W2557746526 @default.
• W4313656208 cites W2558498169 @default.
• W4313656208 cites W2560149596 @default.
• W4313656208 cites W2562013359 @default.
• W4313656208 cites W2604260631 @default.
• W4313656208 cites W2605599897 @default.
• W4313656208 cites W2611303377 @default.
• W4313656208 cites W2611802219 @default.
• W4313656208 cites W2624597159 @default.
• W4313656208 cites W2750650624 @default.
• W4313656208 cites W2754479318 @default.

• next