Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313656421> ?p ?o ?g. }
- W4313656421 abstract "Abstract There have been an increasing number of patients with degenerative disc diseases due to the aging population. In light of this, studies on the pathogenesis of intervertebral disc degeneration have become a hot topic, and gene knockout mice have become a valuable tool in this field of research. With the development of science and technology, constitutive gene knockout mice can be constructed using homologous recombination, zinc finger nuclease, transcription activator‐like effector nuclease technology and clustered regularly interspaced short palindromic repeats/Cas9 (CRISPR/Cas9) system, and conditional gene knockout mice can be constructed using the Cre/LoxP system. The gene‐edited mice using these techniques have been widely used in the studies on disc degeneration. This paper reviews the development process and principles of these technologies, functions of the edited genes in disc degeneration, advantages, and disadvantages of different methods and possible targets of the specific Cre recombinase in intervertebral discs. Recommendations for the choice of suitable gene‐edited model mice are presented. At the same time, possible technological improvements in the future are also discussed." @default.
- W4313656421 created "2023-01-07" @default.
- W4313656421 creator A5002588199 @default.
- W4313656421 creator A5014150237 @default.
- W4313656421 creator A5014261588 @default.
- W4313656421 creator A5015306509 @default.
- W4313656421 creator A5024409086 @default.
- W4313656421 creator A5070059297 @default.
- W4313656421 creator A5072131803 @default.
- W4313656421 date "2023-01-07" @default.
- W4313656421 modified "2023-10-15" @default.
- W4313656421 title "Constitutive and conditional gene knockout mice for the study of intervertebral disc degeneration: Current status, decision considerations, and future possibilities" @default.
- W4313656421 cites W1027656599 @default.
- W4313656421 cites W1101293327 @default.
- W4313656421 cites W129153216 @default.
- W4313656421 cites W14778716 @default.
- W4313656421 cites W163061879 @default.
- W4313656421 cites W1749100053 @default.
- W4313656421 cites W1803264631 @default.
- W4313656421 cites W1872226138 @default.
- W4313656421 cites W1906155566 @default.
- W4313656421 cites W1948541591 @default.
- W4313656421 cites W1968752856 @default.
- W4313656421 cites W1973085055 @default.
- W4313656421 cites W1978129709 @default.
- W4313656421 cites W1981169627 @default.
- W4313656421 cites W1982087641 @default.
- W4313656421 cites W1984361278 @default.
- W4313656421 cites W1986424784 @default.
- W4313656421 cites W1991266458 @default.
- W4313656421 cites W1993834457 @default.
- W4313656421 cites W2000218755 @default.
- W4313656421 cites W2000588164 @default.
- W4313656421 cites W2000672499 @default.
- W4313656421 cites W2003171404 @default.
- W4313656421 cites W2003352875 @default.
- W4313656421 cites W2006847669 @default.
- W4313656421 cites W2010475729 @default.
- W4313656421 cites W2012213982 @default.
- W4313656421 cites W2013879043 @default.
- W4313656421 cites W2015665277 @default.
- W4313656421 cites W2017330739 @default.
- W4313656421 cites W2021103771 @default.
- W4313656421 cites W2023206100 @default.
- W4313656421 cites W2025881568 @default.
- W4313656421 cites W2027936287 @default.
- W4313656421 cites W2028022925 @default.
- W4313656421 cites W2032002636 @default.
- W4313656421 cites W2033767465 @default.
- W4313656421 cites W2034551726 @default.
- W4313656421 cites W2034710807 @default.
- W4313656421 cites W2036678241 @default.
- W4313656421 cites W2040161701 @default.
- W4313656421 cites W2041932501 @default.
- W4313656421 cites W2043523217 @default.
- W4313656421 cites W2043749946 @default.
- W4313656421 cites W2048139403 @default.
- W4313656421 cites W2049853576 @default.
- W4313656421 cites W2052009804 @default.
- W4313656421 cites W2054382585 @default.
- W4313656421 cites W2055007889 @default.
- W4313656421 cites W2056496886 @default.
- W4313656421 cites W2058172887 @default.
- W4313656421 cites W2063133791 @default.
- W4313656421 cites W2073873559 @default.
- W4313656421 cites W2076981337 @default.
- W4313656421 cites W2077372561 @default.
- W4313656421 cites W2078113353 @default.
- W4313656421 cites W2078308455 @default.
- W4313656421 cites W2085848981 @default.
- W4313656421 cites W2085985952 @default.
- W4313656421 cites W2086044412 @default.
- W4313656421 cites W2086211715 @default.
- W4313656421 cites W2087064986 @default.
- W4313656421 cites W2089000296 @default.
- W4313656421 cites W2090204791 @default.
- W4313656421 cites W2092806325 @default.
- W4313656421 cites W2095192114 @default.
- W4313656421 cites W2102171639 @default.
- W4313656421 cites W2103184796 @default.
- W4313656421 cites W2109105290 @default.
- W4313656421 cites W2117812770 @default.
- W4313656421 cites W2118746294 @default.
- W4313656421 cites W2118949960 @default.
- W4313656421 cites W2120690411 @default.
- W4313656421 cites W2121607378 @default.
- W4313656421 cites W2122048456 @default.
- W4313656421 cites W2147112193 @default.
- W4313656421 cites W2149551358 @default.
- W4313656421 cites W2153137186 @default.
- W4313656421 cites W2158088509 @default.
- W4313656421 cites W2160051211 @default.
- W4313656421 cites W2161514295 @default.
- W4313656421 cites W2165564744 @default.
- W4313656421 cites W2172129769 @default.
- W4313656421 cites W2263830966 @default.
- W4313656421 cites W2292388185 @default.
- W4313656421 cites W2323007300 @default.
- W4313656421 cites W2325219057 @default.
- W4313656421 cites W2329323927 @default.