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• W4313679970 abstract "Background. Available data suggest inhibition of the pancreatic local-renin-angiotensin system (RAS) reduces tissue complications of diabetes. The purpose of the present study was to investigate the effect of hydroalcoholic seed extract of Securigera securidaca (S. securidaca) (HESS) on the pancreatic local-RAS and its alternative pathway. Methods. Three doses of HESS were orally administered to three groups of diabetic male Wistar rats, and the results were compared with both diabetic and healthy control groups. After 35 days of treatment, the groups were assessed for the levels of pancreatic local-RAS components, including renin, angiotensinogen, ACE, and Ang II, as well as ACE2 and Ang-(1-7) in the alternative pathway. The effect of herbal medicine treatment on tissue damage status was investigated by evaluating tissue levels of oxidative stress, proinflammatory and anti-inflammatory cytokines, and through histopathological examination of the pancreas. Results. HESS showed a dose-dependent palliative effect on the tissue oxidative stress profile ( <math xmlns=http://www.w3.org/1998/Math/MathML id=M1> <mi>P</mi> <mo><</mo> <mn>0.05</mn> </math> ) as well as the levels of pancreatic local-RAS components ( <math xmlns=http://www.w3.org/1998/Math/MathML id=M2> <mi>P</mi> <mo><</mo> <mn>0.05</mn> </math> ), compared to diabetic control group. Considering the interrelationship between tissue oxidative stress and local-RAS activity, the moderating effect of HESS on this relationship could be attributed to the increase in total tissue antioxidant capacity (TAC) and pancreatic Ang-(1-7) concentration. Decrease in local-RAS activity was associated with decrease in the tissue levels of inflammatory cytokines (IL1, IL6, and TNFα) ( <math xmlns=http://www.w3.org/1998/Math/MathML id=M3> <mi>P</mi> <mo><</mo> <mn>0.05</mn> </math> ) and increase in the levels of anti-inflammatory cytokine of IL-10 ( <math xmlns=http://www.w3.org/1998/Math/MathML id=M4> <mi>P</mi> <mo><</mo> <mn>0.05</mn> </math> ). In addition, histological results were consistent with tissue biochemical results. Conclusions. Due to the reduction of local pancreatic RAS activity as well as oxidative stress and proinflammatory cytokines following treatment with HESS, S. securidaca seed can be proposed as a suitable herbal supplement in the drug-treatment of diabetes." @default.
• W4313679970 created "2023-01-08" @default.
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• W4313679970 date "2023-01-07" @default.
• W4313679970 modified "2023-09-30" @default.
• W4313679970 title "Effectiveness of Hydroalcoholic Seed Extract of Securigera securidaca on Pancreatic Local Renin-Angiotensin System and Its Alternative Pathway in Streptozotocin-Induced Diabetic Animal Model" @default.
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• W4313679970 doi "https://doi.org/10.1155/2023/7285036" @default.
• W4313679970 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36647426" @default.
• W4313679970 hasPublicationYear "2023" @default.
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