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- W4313682114 abstract "Abstract Survival of living organisms is fully dependent on their maintenance of genome integrity, being permanently threatened by replication stress in proliferating cells. Although the plant DNA damage response (DDR) regulator SOG1 has been demonstrated to cope with replicative defects, accumulating evidence points to other pathways functioning independently of SOG1. Here, we have studied the role of the Arabidopsis E2FA and EF2B transcription factors, two well-characterized regulators of DNA replication, in the response to replication stress. Through a combination of reverse genetics and chromatin-immunoprecipitation approaches, we show that E2FA and E2FB share many target genes with SOG1, providing evidence for their involvement in the DDR. Analysis of double and triple mutant combinations revealed that E2FB, rather than E2FA, plays the most prominent role in sustaining growth in the presence of replicative defects, either operating antagonistically or synergistically with SOG1. Reversely, SOG1 aids in overcoming the replication defects of E2FA/E2FB-deficient plants. Our data reveal a complex transcriptional network controlling the replication stress response, in which both E2Fs and SOG1 act as key regulatory factors. ONE-SENTENCE SUMMARY The Arabidopsis E2FA and EF2B transcription factors differently contribute to the plant’s response to DNA replication defects in a cooperative way with the DNA damage response regulator SOG1." @default.
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- W4313682114 date "2023-01-07" @default.
- W4313682114 modified "2023-10-18" @default.
- W4313682114 title "Distinctive and complementary roles of E2F transcription factors during plant replication stress responses" @default.
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- W4313682114 doi "https://doi.org/10.1101/2023.01.06.523015" @default.
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