FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313702122> ?p ?o ?g. }

• W4313702122 abstract "Abstract Background Artemisinin-based combination therapy (ACT) for the treatment of malaria is highly effective, well tolerated and safe. Episodes of delayed haemolysis occur in up to 57.9% of patients with severe malaria treated with intravenous artesunate, mainly caused by ‘pitting’ of infected red blood cells in the spleen and the delayed loss of these once-infected RBCs (oiRBCs). Several reports indicate that post-treatment haemolysis (PTH) also occurs in uncomplicated malaria treated with oral ACT, calling for systematic investigation. Methods A prospective observational study to identify the incidence of PTH after oral ACT, defined as increased lactate dehydrogenase activity and low haptoglobin level on Day 14 after treatment. Patients were enrolled at two study centres in Germany and Italy. Study visits took place on Days 1, 3, 7, 14 and 28. Laboratory investigations included extended clinical routine laboratory tests, quantitative PfHRP2, anti-RBC antibodies and oiRBCs. The state of semi-immunity to malaria was assessed from childhood and ongoing exposure to Plasmodium spp. as per patient history. Results A total of 134 patients with uncomplicated malaria and 3-day ACT treatment were recruited. Thirty-seven (37.4%) of 99 evaluable patients with Pf and none of 9 patients with non-Pf malaria exhibited PTH on d14. Patients with PTH had higher initial parasitaemia, higher oiRBC counts on d3 and a 10-fold decrease in oiRBCs between d7 and d14 compared with patients without PTH. In patients with PTH, loss of haemoglobin was 4-fold greater in non-Africans than in Africans (−1.3 vs −0.3 g/dl). Semi-immune African patients with PTH showed markedly increased erythropoiesis on d14 compared with not semi-immune African and non-African patients with PTH. Conclusions PTH is common in patients with uncomplicated malaria and oral ACT. While the observed loss of haemoglobin will often not be clinically relevant, it could aggravate pre-existing anaemia, warranting follow-up examinations in populations at risk." @default.
• W4313702122 created "2023-01-08" @default.
• W4313702122 creator A5002185806 @default.
• W4313702122 creator A5006799201 @default.
• W4313702122 creator A5009022259 @default.
• W4313702122 creator A5009593572 @default.
• W4313702122 creator A5010940785 @default.
• W4313702122 creator A5021295461 @default.
• W4313702122 creator A5035224390 @default.
• W4313702122 creator A5040615109 @default.
• W4313702122 creator A5040990793 @default.
• W4313702122 creator A5046831274 @default.
• W4313702122 creator A5053804744 @default.
• W4313702122 creator A5058592648 @default.
• W4313702122 creator A5060098115 @default.
• W4313702122 creator A5067716705 @default.
• W4313702122 creator A5069979236 @default.
• W4313702122 creator A5073524426 @default.
• W4313702122 creator A5074607200 @default.
• W4313702122 creator A5084600026 @default.
• W4313702122 date "2023-01-05" @default.
• W4313702122 modified "2023-09-30" @default.
• W4313702122 title "Post-treatment haemolysis is common following oral artemisinin combination therapy of uncomplicated malaria in travellers" @default.
• W4313702122 cites W1908980906 @default.
• W4313702122 cites W1965705818 @default.
• W4313702122 cites W1972406669 @default.
• W4313702122 cites W2028489709 @default.
• W4313702122 cites W2040239301 @default.
• W4313702122 cites W2049063084 @default.
• W4313702122 cites W2055490973 @default.
• W4313702122 cites W2106017124 @default.
• W4313702122 cites W2127118084 @default.
• W4313702122 cites W2134016435 @default.
• W4313702122 cites W2135011211 @default.
• W4313702122 cites W2140063726 @default.
• W4313702122 cites W2151797721 @default.
• W4313702122 cites W2153266724 @default.
• W4313702122 cites W2166143794 @default.
• W4313702122 cites W2216031912 @default.
• W4313702122 cites W2252393368 @default.
• W4313702122 cites W2467290187 @default.
• W4313702122 cites W2565054976 @default.
• W4313702122 cites W2583238537 @default.
• W4313702122 cites W2626424049 @default.
• W4313702122 cites W2745763502 @default.
• W4313702122 cites W2937495122 @default.
• W4313702122 cites W2944745977 @default.
• W4313702122 cites W2981024072 @default.
• W4313702122 cites W3130156216 @default.
• W4313702122 cites W3134519855 @default.
• W4313702122 cites W3139298225 @default.
• W4313702122 cites W3157378397 @default.
• W4313702122 cites W3214632954 @default.
• W4313702122 cites W4200110643 @default.
• W4313702122 cites W4243658490 @default.
• W4313702122 cites W4283383900 @default.
• W4313702122 cites W3009607940 @default.
• W4313702122 doi "https://doi.org/10.1093/jtm/taad001" @default.
• W4313702122 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36611010" @default.
• W4313702122 hasPublicationYear "2023" @default.
• W4313702122 type Work @default.
• W4313702122 citedByCount "2" @default.
• W4313702122 countsByYear W43137021222023 @default.
• W4313702122 crossrefType "journal-article" @default.
• W4313702122 hasAuthorship W4313702122A5002185806 @default.
• W4313702122 hasAuthorship W4313702122A5006799201 @default.
• W4313702122 hasAuthorship W4313702122A5009022259 @default.
• W4313702122 hasAuthorship W4313702122A5009593572 @default.
• W4313702122 hasAuthorship W4313702122A5010940785 @default.
• W4313702122 hasAuthorship W4313702122A5021295461 @default.
• W4313702122 hasAuthorship W4313702122A5035224390 @default.
• W4313702122 hasAuthorship W4313702122A5040615109 @default.
• W4313702122 hasAuthorship W4313702122A5040990793 @default.
• W4313702122 hasAuthorship W4313702122A5046831274 @default.
• W4313702122 hasAuthorship W4313702122A5053804744 @default.
• W4313702122 hasAuthorship W4313702122A5058592648 @default.
• W4313702122 hasAuthorship W4313702122A5060098115 @default.
• W4313702122 hasAuthorship W4313702122A5067716705 @default.
• W4313702122 hasAuthorship W4313702122A5069979236 @default.
• W4313702122 hasAuthorship W4313702122A5073524426 @default.
• W4313702122 hasAuthorship W4313702122A5074607200 @default.
• W4313702122 hasAuthorship W4313702122A5084600026 @default.
• W4313702122 hasBestOaLocation W43137021221 @default.
• W4313702122 hasConcept C126322002 @default.
• W4313702122 hasConcept C141071460 @default.
• W4313702122 hasConcept C203014093 @default.
• W4313702122 hasConcept C2776120307 @default.
• W4313702122 hasConcept C2776999253 @default.
• W4313702122 hasConcept C2778048844 @default.
• W4313702122 hasConcept C2778059366 @default.
• W4313702122 hasConcept C2778371730 @default.
• W4313702122 hasConcept C2910801743 @default.
• W4313702122 hasConcept C71924100 @default.
• W4313702122 hasConcept C90924648 @default.
• W4313702122 hasConceptScore W4313702122C126322002 @default.
• W4313702122 hasConceptScore W4313702122C141071460 @default.
• W4313702122 hasConceptScore W4313702122C203014093 @default.
• W4313702122 hasConceptScore W4313702122C2776120307 @default.
• W4313702122 hasConceptScore W4313702122C2776999253 @default.
• W4313702122 hasConceptScore W4313702122C2778048844 @default.

• next