Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313702420> ?p ?o ?g. }
- W4313702420 abstract "Abstract Paranoia is a highly debilitating, core element of psychosis, although is poorly managed. Theories of paranoia mostly interface with short-scale or cross-sectional data models, leaving the longitudinal course of paranoia underspecified. Here, we develop an empirical characterisation of two aspects of paranoia - persecutory and referential delusions - in individuals with psychosis over 20 years. We examine delusional dynamics by applying a Graphical Vector Autoregression Model to data collected from the Chicago Follow-up Study (n=135 with a range of psychosis-spectrum diagnoses). We adjusted for age, sex, IQ, and antipsychotic use. We found that referential and persecutory delusions are central themes, supported by other primary delusions, and are strongly autoregressive – the presence of referential and persecutory delusions is predictive of their future occurrence. In a second analysis we demonstrate that social factors influence the severity of referential, but not persecutory, delusions. We suggest that persecutory delusions represent central, resistant states in the cognitive landscape, whereas referential beliefs are more flexible, offering an important window of opportunity for intervention. Our data models can be collated with prior biological, computational, and social work to contribute toward a more complete theory of paranoia and provide more time-dependent evidence for optimal treatment targets. Graphical Abstract Highlights Persecutory and referential delusions are central themes amongst primary delusions in chronic psychosis. Persecutory and referential delusions share a recursive relationship and are both strongly and positively autoregressive. Greater number and quality of friends reduce referential, but not persecutory, delusions. Our formal data model can be used as a test bed and framework for clinical intervention." @default.
- W4313702420 created "2023-01-08" @default.
- W4313702420 creator A5002596278 @default.
- W4313702420 creator A5041172016 @default.
- W4313702420 creator A5050675565 @default.
- W4313702420 creator A5074089013 @default.
- W4313702420 date "2023-01-07" @default.
- W4313702420 modified "2023-10-01" @default.
- W4313702420 title "Modelling the Longitudinal Dynamics of Paranoia in Psychosis: A Temporal Network Analysis Over 20 Years" @default.
- W4313702420 cites W1519776696 @default.
- W4313702420 cites W1974702488 @default.
- W4313702420 cites W1998125876 @default.
- W4313702420 cites W1998641882 @default.
- W4313702420 cites W1999627029 @default.
- W4313702420 cites W2013939918 @default.
- W4313702420 cites W2022646248 @default.
- W4313702420 cites W2036939670 @default.
- W4313702420 cites W2064794182 @default.
- W4313702420 cites W2075980456 @default.
- W4313702420 cites W2097502943 @default.
- W4313702420 cites W2099427809 @default.
- W4313702420 cites W2102138443 @default.
- W4313702420 cites W2107888576 @default.
- W4313702420 cites W2131974041 @default.
- W4313702420 cites W2135808413 @default.
- W4313702420 cites W2138611879 @default.
- W4313702420 cites W2139685490 @default.
- W4313702420 cites W2140668459 @default.
- W4313702420 cites W2146809691 @default.
- W4313702420 cites W2158853806 @default.
- W4313702420 cites W2160735214 @default.
- W4313702420 cites W2268291092 @default.
- W4313702420 cites W2276520418 @default.
- W4313702420 cites W2277233298 @default.
- W4313702420 cites W2326447132 @default.
- W4313702420 cites W2331661890 @default.
- W4313702420 cites W2411560840 @default.
- W4313702420 cites W2460693432 @default.
- W4313702420 cites W2485697939 @default.
- W4313702420 cites W2570888539 @default.
- W4313702420 cites W2582359469 @default.
- W4313702420 cites W2582550385 @default.
- W4313702420 cites W2599899556 @default.
- W4313702420 cites W2616641613 @default.
- W4313702420 cites W2734798982 @default.
- W4313702420 cites W2767326152 @default.
- W4313702420 cites W2783109045 @default.
- W4313702420 cites W2786392325 @default.
- W4313702420 cites W2795897604 @default.
- W4313702420 cites W2805903036 @default.
- W4313702420 cites W2806110837 @default.
- W4313702420 cites W2884592717 @default.
- W4313702420 cites W2925073623 @default.
- W4313702420 cites W2958577954 @default.
- W4313702420 cites W2963732857 @default.
- W4313702420 cites W2982599947 @default.
- W4313702420 cites W3001747545 @default.
- W4313702420 cites W3006074593 @default.
- W4313702420 cites W3008132719 @default.
- W4313702420 cites W3024047195 @default.
- W4313702420 cites W3030282696 @default.
- W4313702420 cites W3039349005 @default.
- W4313702420 cites W3048002145 @default.
- W4313702420 cites W3068863446 @default.
- W4313702420 cites W3080464884 @default.
- W4313702420 cites W3087132881 @default.
- W4313702420 cites W3092683103 @default.
- W4313702420 cites W3118353306 @default.
- W4313702420 cites W3120297945 @default.
- W4313702420 cites W3120875310 @default.
- W4313702420 cites W3123354371 @default.
- W4313702420 cites W3127079568 @default.
- W4313702420 cites W3129957462 @default.
- W4313702420 cites W3130490927 @default.
- W4313702420 cites W3135271196 @default.
- W4313702420 cites W3191819586 @default.
- W4313702420 cites W3197457856 @default.
- W4313702420 cites W4210651558 @default.
- W4313702420 cites W4214946570 @default.
- W4313702420 cites W4224040440 @default.
- W4313702420 cites W4283022222 @default.
- W4313702420 cites W4285726648 @default.
- W4313702420 cites W4287510310 @default.
- W4313702420 cites W4289834997 @default.
- W4313702420 cites W4290087485 @default.
- W4313702420 cites W4302307098 @default.
- W4313702420 cites W4303187463 @default.
- W4313702420 cites W4380758341 @default.
- W4313702420 cites W623114810 @default.
- W4313702420 doi "https://doi.org/10.1101/2023.01.06.23284268" @default.
- W4313702420 hasPublicationYear "2023" @default.
- W4313702420 type Work @default.
- W4313702420 citedByCount "0" @default.
- W4313702420 crossrefType "posted-content" @default.
- W4313702420 hasAuthorship W4313702420A5002596278 @default.
- W4313702420 hasAuthorship W4313702420A5041172016 @default.
- W4313702420 hasAuthorship W4313702420A5050675565 @default.
- W4313702420 hasAuthorship W4313702420A5074089013 @default.
- W4313702420 hasBestOaLocation W43137024201 @default.
- W4313702420 hasConcept C118552586 @default.