Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313702429> ?p ?o ?g. }
- W4313702429 abstract "ABSTRACT Pathogens secrete effector proteins to subvert host physiology and cause disease. Effectors are engaged in a molecular arms race with the host resulting in conflicting evolutionary constraints to manipulate host cells without triggering immune responses. The molecular mechanisms allowing effectors to be at the same time robust and evolvable remain largely enigmatic. Here, we show that 62 conserved structure-related families encompass the majority of fungal orphan effector candidates at the subphylum level. These effectors diversified through changes in patterns of thermodynamic frustration at surface residues. The underlying mutations tended to increase the robustness of the overall effector protein structure while switching potential binding interfaces. This mechanism could explain how conserved effector families maintained biological activity over long evolutionary timespans in different host environments and provides a model for the emergence of sequence-unrelated effector families with conserved structures." @default.
- W4313702429 created "2023-01-08" @default.
- W4313702429 creator A5073950892 @default.
- W4313702429 creator A5074393350 @default.
- W4313702429 date "2023-01-07" @default.
- W4313702429 modified "2023-09-30" @default.
- W4313702429 title "Surface frustration re-patterning underlies the structural landscape and evolvability of fungal orphan candidate effectors" @default.
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