Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313702626> ?p ?o ?g. }
- W4313702626 abstract "Abstract Metalloproteins are well-known for playing various physicochemical processes in all life forms, including viruses. Some life-threatening viruses (such as some members of the Coronaviridae family of viruses) are emerged and remerged frequently and are rapidly transmitted throughout the globe. This study aims to identify and characterize the metal-binding proteins (MBPs) of the Coronaviridae family of viruses and further provides insight into the MBP’s role in sustaining and propagating viruses inside a host cell and in the outer environment. In this study, the available proteome of the Coronaviridae family was exploited. Identified potential MBPs were analyzed for their functional domains, structural aspects, and subcellular localization. We also demonstrate phylogenetic aspects of all predicted MBPs among other Coronaviridae family members to understand the evolutionary trend among their respective hosts. A total of 256 proteins from 51 different species of coronaviruses are predicted as MBPs. These MBPs perform various key roles in the replication and survival of viruses within the host cell. Cysteine, aspartic acid, threonine, and glutamine are key amino acid residues interacting with respective metal ions. Our observations also indicate that the metalloproteins of this family of viruses circulated and evolved in different hosts, which supports the zoonotic nature of coronaviruses. The comprehensive information on MBPs of the Coronaviridae family may be further helpful in designing novel therapeutic metalloprotein targets. Moreover, the study of viral MBPs can also help to understand the roles of MBPs in virus pathogenesis and virus–host interactions." @default.
- W4313702626 created "2023-01-08" @default.
- W4313702626 creator A5000551221 @default.
- W4313702626 creator A5000874346 @default.
- W4313702626 creator A5089686301 @default.
- W4313702626 creator A5021322127 @default.
- W4313702626 date "2023-01-01" @default.
- W4313702626 modified "2023-10-13" @default.
- W4313702626 title "The putative metal-binding proteome of the Coronaviridae family" @default.
- W4313702626 cites W117713865 @default.
- W4313702626 cites W1803102843 @default.
- W4313702626 cites W1988635175 @default.
- W4313702626 cites W1999009084 @default.
- W4313702626 cites W2040463885 @default.
- W4313702626 cites W2041802815 @default.
- W4313702626 cites W2058465738 @default.
- W4313702626 cites W2064186839 @default.
- W4313702626 cites W2071816962 @default.
- W4313702626 cites W2091448229 @default.
- W4313702626 cites W2092146175 @default.
- W4313702626 cites W2093499429 @default.
- W4313702626 cites W2127322768 @default.
- W4313702626 cites W2128934600 @default.
- W4313702626 cites W2158714788 @default.
- W4313702626 cites W2159148537 @default.
- W4313702626 cites W2168058489 @default.
- W4313702626 cites W2170747616 @default.
- W4313702626 cites W2519928122 @default.
- W4313702626 cites W2559191318 @default.
- W4313702626 cites W2559258718 @default.
- W4313702626 cites W2587582684 @default.
- W4313702626 cites W2611454163 @default.
- W4313702626 cites W2751583588 @default.
- W4313702626 cites W2783033457 @default.
- W4313702626 cites W2793008036 @default.
- W4313702626 cites W2799524357 @default.
- W4313702626 cites W2807288347 @default.
- W4313702626 cites W2807766837 @default.
- W4313702626 cites W2889619860 @default.
- W4313702626 cites W2907970204 @default.
- W4313702626 cites W2910794618 @default.
- W4313702626 cites W2911284263 @default.
- W4313702626 cites W2927961455 @default.
- W4313702626 cites W2942527641 @default.
- W4313702626 cites W2949424106 @default.
- W4313702626 cites W2968035172 @default.
- W4313702626 cites W3000771439 @default.
- W4313702626 cites W3000834295 @default.
- W4313702626 cites W3006165086 @default.
- W4313702626 cites W3007940623 @default.
- W4313702626 cites W3024856896 @default.
- W4313702626 cites W3029223018 @default.
- W4313702626 cites W3034695509 @default.
- W4313702626 cites W3037292993 @default.
- W4313702626 cites W3045355728 @default.
- W4313702626 cites W3048996456 @default.
- W4313702626 cites W3080845626 @default.
- W4313702626 cites W3089336694 @default.
- W4313702626 cites W3092650667 @default.
- W4313702626 cites W3093304440 @default.
- W4313702626 cites W3095583226 @default.
- W4313702626 cites W3100369134 @default.
- W4313702626 cites W3105885554 @default.
- W4313702626 cites W3107076553 @default.
- W4313702626 cites W3118921805 @default.
- W4313702626 cites W3139322491 @default.
- W4313702626 cites W3163430094 @default.
- W4313702626 cites W3164001450 @default.
- W4313702626 cites W3164252023 @default.
- W4313702626 cites W3183167124 @default.
- W4313702626 cites W3193203642 @default.
- W4313702626 cites W3195606942 @default.
- W4313702626 cites W4211151236 @default.
- W4313702626 cites W4231059664 @default.
- W4313702626 cites W4242414768 @default.
- W4313702626 cites W4243300758 @default.
- W4313702626 cites W4283745917 @default.
- W4313702626 cites W856957622 @default.
- W4313702626 doi "https://doi.org/10.1093/mtomcs/mfad001" @default.
- W4313702626 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36610727" @default.
- W4313702626 hasPublicationYear "2023" @default.
- W4313702626 type Work @default.
- W4313702626 citedByCount "2" @default.
- W4313702626 countsByYear W43137026262023 @default.
- W4313702626 crossrefType "journal-article" @default.
- W4313702626 hasAuthorship W4313702626A5000551221 @default.
- W4313702626 hasAuthorship W4313702626A5000874346 @default.
- W4313702626 hasAuthorship W4313702626A5021322127 @default.
- W4313702626 hasAuthorship W4313702626A5089686301 @default.
- W4313702626 hasConcept C104317684 @default.
- W4313702626 hasConcept C104397665 @default.
- W4313702626 hasConcept C142724271 @default.
- W4313702626 hasConcept C17165728 @default.
- W4313702626 hasConcept C181199279 @default.
- W4313702626 hasConcept C2776844884 @default.
- W4313702626 hasConcept C2779134260 @default.
- W4313702626 hasConcept C3008058167 @default.
- W4313702626 hasConcept C34905852 @default.
- W4313702626 hasConcept C46111723 @default.
- W4313702626 hasConcept C524204448 @default.