FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313702687> ?p ?o ?g. }

• W4313702687 endingPage "e12820" @default.
• W4313702687 startingPage "e12820" @default.
• W4313702687 abstract "Radioresistance is the major factor of glioblastoma multiforme (GBM) treatment failure and relapse. Hypoxia and autophagy are linked to radioresistance and poor prognosis in solid tumors, but mechanisms remain unknown. Thus, we hypothesize that hypoxia may activate autophagy through two critical factors, HIF1A and Beclin-1, resulting in radioresistance of GBM in vitro and in vivo. In this study, we first demonstrated that HIF1A was overexpressed in GBM tissues and predicted a poor prognosis via bioinformatics. Secondly, we determined that hypoxia induced high expression of HIF1A and upregulated levels of Beclin-1 and autophagy, while HIF1A knockdown by shRNA reduced the expression of Beclin-1. Then we revealed the crosstalk and mechanisms of HIF1A-associated-Beclin-1 in three aspects: (a) transcriptional regulation, (b) protein interaction, and (c) HIF1A/BNIP3/Beclin-1 signaling pathway. Furthermore, we confirmed that silencing HIF1A enhanced the radiosensitivity of GBM in vitro and in vivo. Additionally, Beclin-1 suppression by 3-MA could reverse radioresistance induced by HIF1A under hypoxia. In conclusion, we demonstrated that hypoxia triggered autophagy via HIF1A-associated Beclin-1, resulting in radioresistance in GBM. HIF1A knockdown improved GBM radiosensitivity, and silencing Beclin-1 could reverse HIF1A-induced radioresistance under hypoxic conditions. These findings may help us comprehend the molecular underpinnings of hypoxia-induced autophagy and provide a novel perspective and prospective treatment for GBM radiosensitization." @default.
• W4313702687 created "2023-01-08" @default.
• W4313702687 creator A5003771239 @default.
• W4313702687 creator A5016848207 @default.
• W4313702687 creator A5023976350 @default.
• W4313702687 creator A5032966102 @default.
• W4313702687 creator A5038108244 @default.
• W4313702687 creator A5051708739 @default.
• W4313702687 creator A5054199475 @default.
• W4313702687 creator A5057859102 @default.
• W4313702687 creator A5088851867 @default.
• W4313702687 date "2023-01-01" @default.
• W4313702687 modified "2023-09-23" @default.
• W4313702687 title "Hypoxia-Induced Autophagy Is Involved in Radioresistance via HIF1A-Associated Beclin-1 in Glioblastoma Multiforme" @default.
• W4313702687 cites W1019836896 @default.
• W4313702687 cites W1855648015 @default.
• W4313702687 cites W1976880272 @default.
• W4313702687 cites W1979561126 @default.
• W4313702687 cites W1982626083 @default.
• W4313702687 cites W1988938307 @default.
• W4313702687 cites W1989051519 @default.
• W4313702687 cites W2004333139 @default.
• W4313702687 cites W2022501326 @default.
• W4313702687 cites W2027951311 @default.
• W4313702687 cites W2030575063 @default.
• W4313702687 cites W2033987226 @default.
• W4313702687 cites W2055145844 @default.
• W4313702687 cites W2055751151 @default.
• W4313702687 cites W2058188455 @default.
• W4313702687 cites W2060480804 @default.
• W4313702687 cites W2064720809 @default.
• W4313702687 cites W2066964642 @default.
• W4313702687 cites W2067149213 @default.
• W4313702687 cites W2074429674 @default.
• W4313702687 cites W2075140861 @default.
• W4313702687 cites W2079729042 @default.
• W4313702687 cites W2082535456 @default.
• W4313702687 cites W2084955234 @default.
• W4313702687 cites W2085255144 @default.
• W4313702687 cites W2090050412 @default.
• W4313702687 cites W2096287682 @default.
• W4313702687 cites W2099776053 @default.
• W4313702687 cites W2101291628 @default.
• W4313702687 cites W2103596198 @default.
• W4313702687 cites W2104381422 @default.
• W4313702687 cites W2117897302 @default.
• W4313702687 cites W2120090919 @default.
• W4313702687 cites W2125257427 @default.
• W4313702687 cites W2135574023 @default.
• W4313702687 cites W2136568101 @default.
• W4313702687 cites W2136586665 @default.
• W4313702687 cites W2151335185 @default.
• W4313702687 cites W2158535498 @default.
• W4313702687 cites W2163182836 @default.
• W4313702687 cites W2166798417 @default.
• W4313702687 cites W2174852849 @default.
• W4313702687 cites W2255847952 @default.
• W4313702687 cites W2411099800 @default.
• W4313702687 cites W2411995195 @default.
• W4313702687 cites W2424815387 @default.
• W4313702687 cites W2599750069 @default.
• W4313702687 cites W3097339274 @default.
• W4313702687 cites W651409287 @default.
• W4313702687 doi "https://doi.org/10.1016/j.heliyon.2023.e12820" @default.
• W4313702687 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36691538" @default.
• W4313702687 hasPublicationYear "2023" @default.
• W4313702687 type Work @default.
• W4313702687 citedByCount "1" @default.
• W4313702687 countsByYear W43137026872023 @default.
• W4313702687 crossrefType "journal-article" @default.
• W4313702687 hasAuthorship W4313702687A5003771239 @default.
• W4313702687 hasAuthorship W4313702687A5016848207 @default.
• W4313702687 hasAuthorship W4313702687A5023976350 @default.
• W4313702687 hasAuthorship W4313702687A5032966102 @default.
• W4313702687 hasAuthorship W4313702687A5038108244 @default.
• W4313702687 hasAuthorship W4313702687A5051708739 @default.
• W4313702687 hasAuthorship W4313702687A5054199475 @default.
• W4313702687 hasAuthorship W4313702687A5057859102 @default.
• W4313702687 hasAuthorship W4313702687A5088851867 @default.
• W4313702687 hasBestOaLocation W43137026871 @default.
• W4313702687 hasConcept C104317684 @default.
• W4313702687 hasConcept C119056186 @default.
• W4313702687 hasConcept C126322002 @default.
• W4313702687 hasConcept C173396325 @default.
• W4313702687 hasConcept C178790620 @default.
• W4313702687 hasConcept C185592680 @default.
• W4313702687 hasConcept C190283241 @default.
• W4313702687 hasConcept C203522944 @default.
• W4313702687 hasConcept C206684579 @default.
• W4313702687 hasConcept C2780394083 @default.
• W4313702687 hasConcept C31194975 @default.
• W4313702687 hasConcept C502942594 @default.
• W4313702687 hasConcept C509974204 @default.
• W4313702687 hasConcept C540031477 @default.
• W4313702687 hasConcept C54355233 @default.
• W4313702687 hasConcept C58962609 @default.
• W4313702687 hasConcept C71924100 @default.
• W4313702687 hasConcept C7836513 @default.

• next