FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313702950> ?p ?o ?g. }

• W4313702950 endingPage "116134" @default.
• W4313702950 startingPage "116134" @default.
• W4313702950 abstract "Yupingfeng San (YPFS) is a classic rousing prescription in Chinese medicine, with widly clinical application and remarkably curative effect. It consists of three herbs named Astragalus mongholicus Bunge (Huangqi), Atractylodes rubra Dekker (Baizhu) and Saposhnikovia divaricata (Turcz.) Schischk. (Fangfeng), and has a variety of pharmacological activities including immune regulation, antioxidant, anti-tumor, regulation of cytokines, etc. It has been proved that YPFS exerts its anti-tumor effect through enhancing the systemic and local immune responses in tumor patients, moreover, it has the direct tumor-suppressing effect and can reduce the adverse reactions caused by radiotherapy and chemotherapy drugs. Therefore, in this study, we explored the potential anti-HCC mechanism of YPFS based on HTS2 technology and systems pharmacology, aiming to provide a scientific basis for the clinical application of YPFS and a new strategy for Chinese medicine research. In this study, systems pharmacology plus high throughput sequencing-based high throughput screening (HTS2) technology, and experimental validation were used to investigate the therapeutic mechanisms and the chemical basis of YPFS in HCC treatment. Firstly, the potential therapeutic targets and signaling pathways of YPFS in the treatment of HCC were obtained through systems pharmacology. Subsequently, HTS2 technology combined with PPI network analysis were used to reveal potential therapeutic targets. Finally, the anti-HCC effects and underlying mechanisms of YPFS were further verified in vitro in human hepatocellular carcinoma cell lines. Moreover, the possible chemical basis was explored by drug target verification and molecular docking technology. In total, 183 active ingredients were predicted by YPFS screening and 49 anti-HCC targets were further identified. Most of these targets were enriched into the “MAPK pathway”, and the expression of 37 genes was significantly changed after herb treatment. Among them, 5 key targets, including VEGFA, GRB2, JUN, PDGFRB and CDC42, were predicted by protein-protein interaction (PPI) network analysis. According to our results, YPFS inhibited the proliferation, induced the apoptosis and caused cell cycle arrest of HCC cells. In addition, YPFS significantly reduced P38 gene expression. Fangfeng, one of the three herbs in YPFS, significantly down-regulated the expression of more target genes than that of the other two herbs. Lastly, as revealed by molecular docking analysis, 4′-O-glucosyl-5-O-methylvisamminol, an active ingredient identified in Fangfeng, showed a high affinity for P38. Taken together, this study shows that YPFS possesses the activities of anti-proliferation and pro-apoptosis in treating HCC, which are achieved by inhibiting the MAPK signaling pathway. P38 is one of the critical targets of YPFS in treating HCC, which may be directly bound and inhibited by 4′-O-glucosyl-5-O-methylvisamminol, a compound derived from YPFS." @default.
• W4313702950 created "2023-01-08" @default.
• W4313702950 creator A5008142405 @default.
• W4313702950 creator A5023919136 @default.
• W4313702950 creator A5027665139 @default.
• W4313702950 creator A5035635699 @default.
• W4313702950 creator A5038488987 @default.
• W4313702950 creator A5046454314 @default.
• W4313702950 creator A5069273969 @default.
• W4313702950 creator A5075170039 @default.
• W4313702950 creator A5075822447 @default.
• W4313702950 creator A5084076493 @default.
• W4313702950 creator A5091388605 @default.
• W4313702950 date "2023-04-01" @default.
• W4313702950 modified "2023-10-16" @default.
• W4313702950 title "Yupingfeng San exhibits anticancer effect in hepatocellular carcinoma cells via the MAPK pathway revealed by HTS2 technology" @default.
• W4313702950 cites W1565491355 @default.
• W4313702950 cites W1982830461 @default.
• W4313702950 cites W1983198554 @default.
• W4313702950 cites W1985151716 @default.
• W4313702950 cites W1986735026 @default.
• W4313702950 cites W1995938892 @default.
• W4313702950 cites W2019017694 @default.
• W4313702950 cites W2025738474 @default.
• W4313702950 cites W2036606290 @default.
• W4313702950 cites W2039578740 @default.
• W4313702950 cites W2055386134 @default.
• W4313702950 cites W2068480471 @default.
• W4313702950 cites W2114843025 @default.
• W4313702950 cites W2122037714 @default.
• W4313702950 cites W2123500593 @default.
• W4313702950 cites W2124679671 @default.
• W4313702950 cites W2131474511 @default.
• W4313702950 cites W2132085073 @default.
• W4313702950 cites W2158217645 @default.
• W4313702950 cites W2172189015 @default.
• W4313702950 cites W2285954818 @default.
• W4313702950 cites W2472672348 @default.
• W4313702950 cites W2514947134 @default.
• W4313702950 cites W2607129810 @default.
• W4313702950 cites W2620998958 @default.
• W4313702950 cites W2766490148 @default.
• W4313702950 cites W2794353845 @default.
• W4313702950 cites W2801946069 @default.
• W4313702950 cites W2884114547 @default.
• W4313702950 cites W2950764390 @default.
• W4313702950 cites W2950866776 @default.
• W4313702950 cites W2958029267 @default.
• W4313702950 cites W2981680522 @default.
• W4313702950 cites W2981847323 @default.
• W4313702950 cites W2984497827 @default.
• W4313702950 cites W3006573702 @default.
• W4313702950 cites W3016186084 @default.
• W4313702950 cites W3027906585 @default.
• W4313702950 cites W3118808299 @default.
• W4313702950 cites W3157848957 @default.
• W4313702950 cites W3158711754 @default.
• W4313702950 cites W3170750804 @default.
• W4313702950 cites W4210806045 @default.
• W4313702950 doi "https://doi.org/10.1016/j.jep.2023.116134" @default.
• W4313702950 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36627003" @default.
• W4313702950 hasPublicationYear "2023" @default.
• W4313702950 type Work @default.
• W4313702950 citedByCount "3" @default.
• W4313702950 countsByYear W43137029502023 @default.
• W4313702950 crossrefType "journal-article" @default.
• W4313702950 hasAuthorship W4313702950A5008142405 @default.
• W4313702950 hasAuthorship W4313702950A5023919136 @default.
• W4313702950 hasAuthorship W4313702950A5027665139 @default.
• W4313702950 hasAuthorship W4313702950A5035635699 @default.
• W4313702950 hasAuthorship W4313702950A5038488987 @default.
• W4313702950 hasAuthorship W4313702950A5046454314 @default.
• W4313702950 hasAuthorship W4313702950A5069273969 @default.
• W4313702950 hasAuthorship W4313702950A5075170039 @default.
• W4313702950 hasAuthorship W4313702950A5075822447 @default.
• W4313702950 hasAuthorship W4313702950A5084076493 @default.
• W4313702950 hasAuthorship W4313702950A5091388605 @default.
• W4313702950 hasConcept C142724271 @default.
• W4313702950 hasConcept C188947578 @default.
• W4313702950 hasConcept C197934379 @default.
• W4313702950 hasConcept C203014093 @default.
• W4313702950 hasConcept C204787440 @default.
• W4313702950 hasConcept C2778019345 @default.
• W4313702950 hasConcept C502942594 @default.
• W4313702950 hasConcept C55493867 @default.
• W4313702950 hasConcept C556039675 @default.
• W4313702950 hasConcept C57074206 @default.
• W4313702950 hasConcept C62478195 @default.
• W4313702950 hasConcept C71924100 @default.
• W4313702950 hasConcept C86803240 @default.
• W4313702950 hasConcept C8891405 @default.
• W4313702950 hasConcept C98274493 @default.
• W4313702950 hasConceptScore W4313702950C142724271 @default.
• W4313702950 hasConceptScore W4313702950C188947578 @default.
• W4313702950 hasConceptScore W4313702950C197934379 @default.
• W4313702950 hasConceptScore W4313702950C203014093 @default.
• W4313702950 hasConceptScore W4313702950C204787440 @default.
• W4313702950 hasConceptScore W4313702950C2778019345 @default.

• next