Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313703048> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W4313703048 abstract "Abstract Introduction Epigenetic alterations are related to the process of tumorigenesis and resistance to oncological therapies. Although more than 60 types of histone post-translational modifications (HPTMs) have been described, the alterations that manifest simultaneously in tumor tissue have not been systematically studied in colorectal cancer (CRC). This project aims to develop a new screening methodology to delineate epigenetic alterations present in CRC and to obtain a set of biomarkers related to malignancy and tumor response. Methods Using state-of-the-art tandem mass spectrometry (MS-MS) techniques, a direct injection protocol will be performed to simultaneously identify the presence of >200 HPTMs-related peptides in a cohort of primary tumors and paired healthy CRC tissue. Patterning of spectra and statistical analyses will be performed with the automated processing algorithm EpiProfile 2.0. Results A histone extraction protocol optimized for human tumor samples was developed. Likewise, we managed to make MS/MS sample processing more flexible by implementing a multiplatform workflow (Thermo / Sciex), which will increase the screening and data analysis capacity. Through this process we managed to detect >200 peptides related to HPTMs in control samples, and we observed significant differences in certain HPTMs with pharmacological treatments in primary cultures. Conclusions These results will allow the identification of epigenetic biomarkers related to grade, stage and recurrence in the context of CRC." @default.
- W4313703048 created "2023-01-08" @default.
- W4313703048 creator A5006345028 @default.
- W4313703048 creator A5009088559 @default.
- W4313703048 creator A5031974319 @default.
- W4313703048 creator A5046328409 @default.
- W4313703048 creator A5049294456 @default.
- W4313703048 creator A5081179078 @default.
- W4313703048 creator A5082783173 @default.
- W4313703048 date "2023-01-04" @default.
- W4313703048 modified "2023-09-29" @default.
- W4313703048 title "FUNCTIONAL MAPPING OF NOVEL HISTONE POST-TRANSLATIONAL ALTERATIONS IN COLON CANCER" @default.
- W4313703048 doi "https://doi.org/10.1093/bjs/znac443.041" @default.
- W4313703048 hasPublicationYear "2023" @default.
- W4313703048 type Work @default.
- W4313703048 citedByCount "0" @default.
- W4313703048 crossrefType "journal-article" @default.
- W4313703048 hasAuthorship W4313703048A5006345028 @default.
- W4313703048 hasAuthorship W4313703048A5009088559 @default.
- W4313703048 hasAuthorship W4313703048A5031974319 @default.
- W4313703048 hasAuthorship W4313703048A5046328409 @default.
- W4313703048 hasAuthorship W4313703048A5049294456 @default.
- W4313703048 hasAuthorship W4313703048A5081179078 @default.
- W4313703048 hasAuthorship W4313703048A5082783173 @default.
- W4313703048 hasBestOaLocation W43137030481 @default.
- W4313703048 hasConcept C104317684 @default.
- W4313703048 hasConcept C121608353 @default.
- W4313703048 hasConcept C126322002 @default.
- W4313703048 hasConcept C151730666 @default.
- W4313703048 hasConcept C2779343474 @default.
- W4313703048 hasConcept C2779399171 @default.
- W4313703048 hasConcept C41091548 @default.
- W4313703048 hasConcept C502942594 @default.
- W4313703048 hasConcept C526805850 @default.
- W4313703048 hasConcept C54355233 @default.
- W4313703048 hasConcept C555283112 @default.
- W4313703048 hasConcept C60644358 @default.
- W4313703048 hasConcept C64927066 @default.
- W4313703048 hasConcept C70721500 @default.
- W4313703048 hasConcept C71924100 @default.
- W4313703048 hasConcept C86803240 @default.
- W4313703048 hasConceptScore W4313703048C104317684 @default.
- W4313703048 hasConceptScore W4313703048C121608353 @default.
- W4313703048 hasConceptScore W4313703048C126322002 @default.
- W4313703048 hasConceptScore W4313703048C151730666 @default.
- W4313703048 hasConceptScore W4313703048C2779343474 @default.
- W4313703048 hasConceptScore W4313703048C2779399171 @default.
- W4313703048 hasConceptScore W4313703048C41091548 @default.
- W4313703048 hasConceptScore W4313703048C502942594 @default.
- W4313703048 hasConceptScore W4313703048C526805850 @default.
- W4313703048 hasConceptScore W4313703048C54355233 @default.
- W4313703048 hasConceptScore W4313703048C555283112 @default.
- W4313703048 hasConceptScore W4313703048C60644358 @default.
- W4313703048 hasConceptScore W4313703048C64927066 @default.
- W4313703048 hasConceptScore W4313703048C70721500 @default.
- W4313703048 hasConceptScore W4313703048C71924100 @default.
- W4313703048 hasConceptScore W4313703048C86803240 @default.
- W4313703048 hasIssue "Supplement_1" @default.
- W4313703048 hasLocation W43137030481 @default.
- W4313703048 hasOpenAccess W4313703048 @default.
- W4313703048 hasPrimaryLocation W43137030481 @default.
- W4313703048 hasRelatedWork W2062380899 @default.
- W4313703048 hasRelatedWork W2087587415 @default.
- W4313703048 hasRelatedWork W2091632974 @default.
- W4313703048 hasRelatedWork W2104506492 @default.
- W4313703048 hasRelatedWork W2313078169 @default.
- W4313703048 hasRelatedWork W2358152259 @default.
- W4313703048 hasRelatedWork W2382734670 @default.
- W4313703048 hasRelatedWork W2400673127 @default.
- W4313703048 hasRelatedWork W3031314172 @default.
- W4313703048 hasRelatedWork W4317388020 @default.
- W4313703048 hasVolume "110" @default.
- W4313703048 isParatext "false" @default.
- W4313703048 isRetracted "false" @default.
- W4313703048 workType "article" @default.