FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313703102> ?p ?o ?g. }

• W4313703102 endingPage "141" @default.
• W4313703102 startingPage "129" @default.
• W4313703102 abstract "Purpose. Synthesis and study of antioxidant properties of [1,2,4]triazolo[1,5-a]pyridine derivatives and their potential toxicity using preclinical diagnostic methods. Methodology. Derivatives of [1,2,4]triazolo[1,5-a]pyridine were synthesized on the basis of 2-aminopyridines and ethyl isothiacyanatocarbonate, with subsequent cyclization of intermediate adducts. The resulting 2-amino[1,2,4]triazolo[1,5-a]pyridines were reacted with isoamyl nitrite in the presence of CuHal2, which led to the synthesis of volatile 2-halogeno[1,2,4]triazolo[1,5- a]pyridine. The toxicity of the obtained compounds was studied by the degree of hemolysis of erythrocytes in a hypotonic NaCl solution. The intensity of free-radical oxidation of lipids was assessed spectrophotometrically by the formation of TBА-active products. The antioxidant activity of the substances was determined by inhibiting the oxidation of adrenaline under conditions of artificial oxidative stress. Scientific novelty. For the first time, the antioxidant activity of the [1,2,4]triazolo[1,5-a]pyridine derivatives described in the paper was investigated and their toxicity was studied according to the degree of hemolysis of erythrocytes in a hypotonic NaCl solution. Conclusions. The in vitro cytotoxicity study model showed that compounds 5a and 5b, which contain bromine atoms in the 2, 5, and 7 positions of the pyridinotriazole heterosystem, exert the greatest influence on the stability of erythrocyte membranes. The study of antioxidant activity showed that the highest values of antioxidant activity are characteristic of compounds of the 4a-d series, namely compounds 4b and 4c, which are characterized by the presence of an amino group in the 2nd position and the presence of a bromine atom as a substitute in the 1st and 5th positions of the pyridine fragment of the heterosystem. The dynamics of antioxidant activity on the model of inhibition of adrenaline oxidation confirms the opinion about the lowest toxicity and the highest ability to inhibit the formation of reactive oxygen species of compounds 4b and 4c (40.16 and 38.82% relative to ionol). So, with the use of preclinical diagnostic methods, we proved the presence of physicochemical activity in a number of investigated compounds. 2-amino-[1,2,4]triazolo[1,5a]pyridine derivatives with a bromine atom as a substitute in the pyridine fragment of the molecule should be considered as potential antioxidants in the future, and the studied condensed system can be considered a promising heterocyclic framework for creating potential antioxidant agents." @default.
• W4313703102 created "2023-01-08" @default.
• W4313703102 creator A5000428223 @default.
• W4313703102 creator A5024617182 @default.
• W4313703102 creator A5078036789 @default.
• W4313703102 creator A5083901926 @default.
• W4313703102 date "2022-12-29" @default.
• W4313703102 modified "2023-10-06" @default.
• W4313703102 title "SYNTHESIS AND PRECLINICAL STUDY OF ANTIOXIDANT ACTIVITY OF [1,2,4]TRIAZOLO[1,5-A]PYRIDINE DERIVATIVES" @default.
• W4313703102 doi "https://doi.org/10.58407/bht.2.22.10" @default.
• W4313703102 hasPublicationYear "2022" @default.
• W4313703102 type Work @default.
• W4313703102 citedByCount "0" @default.
• W4313703102 crossrefType "journal-article" @default.
• W4313703102 hasAuthorship W4313703102A5000428223 @default.
• W4313703102 hasAuthorship W4313703102A5024617182 @default.
• W4313703102 hasAuthorship W4313703102A5078036789 @default.
• W4313703102 hasAuthorship W4313703102A5083901926 @default.
• W4313703102 hasBestOaLocation W43137031021 @default.
• W4313703102 hasConcept C155647269 @default.
• W4313703102 hasConcept C178790620 @default.
• W4313703102 hasConcept C185592680 @default.
• W4313703102 hasConcept C203014093 @default.
• W4313703102 hasConcept C2778004101 @default.
• W4313703102 hasConcept C2779485729 @default.
• W4313703102 hasConcept C2779902561 @default.
• W4313703102 hasConcept C29730261 @default.
• W4313703102 hasConcept C86803240 @default.
• W4313703102 hasConceptScore W4313703102C155647269 @default.
• W4313703102 hasConceptScore W4313703102C178790620 @default.
• W4313703102 hasConceptScore W4313703102C185592680 @default.
• W4313703102 hasConceptScore W4313703102C203014093 @default.
• W4313703102 hasConceptScore W4313703102C2778004101 @default.
• W4313703102 hasConceptScore W4313703102C2779485729 @default.
• W4313703102 hasConceptScore W4313703102C2779902561 @default.
• W4313703102 hasConceptScore W4313703102C29730261 @default.
• W4313703102 hasConceptScore W4313703102C86803240 @default.
• W4313703102 hasIssue "2" @default.
• W4313703102 hasLocation W43137031021 @default.
• W4313703102 hasOpenAccess W4313703102 @default.
• W4313703102 hasPrimaryLocation W43137031021 @default.
• W4313703102 hasRelatedWork W2018543773 @default.
• W4313703102 hasRelatedWork W2055163967 @default.
• W4313703102 hasRelatedWork W2148787175 @default.
• W4313703102 hasRelatedWork W2395638556 @default.
• W4313703102 hasRelatedWork W2949133395 @default.
• W4313703102 hasRelatedWork W2950355387 @default.
• W4313703102 hasRelatedWork W2951356987 @default.
• W4313703102 hasRelatedWork W2951939317 @default.
• W4313703102 hasRelatedWork W2952175015 @default.
• W4313703102 hasRelatedWork W2997339201 @default.
• W4313703102 isParatext "false" @default.
• W4313703102 isRetracted "false" @default.
• W4313703102 workType "article" @default.