FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313703383> ?p ?o ?g. }

• W4313703383 abstract "Abstract Seroclearance of hepatitis B surface antigen (HBsAg) is regarded as the functional cure for chronic hepatitis B (CHB). The relationship between human leukocyte antigen (HLA) variants, hepatitis B virus genotype, and longitudinal HBsAg serodecline remains to be explored. A total of 1735 HBeAg-seronegative CHB patients with genotype B or C infection of the community-based REVEAL-HBV cohort were genotyped for rs1710 (HLA-G) and rs2770 (HLA-B) using TaqMan assay. Cox proportional hazard regression and generalized linear mixed models were used to analyze the association of HLA genetic variants with the rate of HBsAg seroclearance and longitudinal HBsAg serodecline. Rs1710 G allele was differentially associated with the HBsAg seroclearance in genotype B [aRR (95% CI) = 0.74 (0.56–0.98)] and genotype C [aRR (95%CI) = 1.43 (1.08–1.88)] infection. Rs2770 G allele was associated with HBsAg seroclearance only in genotype B infection [aRR (95% CI) = 0.69 (0.52–0.91)]. The alleles associated with HBsAg seroclearance were significant predictors for the serodecline of HBsAg levels in an HBV genotype-dependent manner (genotype B infection: rs1710, P = 0.013; rs2770, P = 0.0081; genotype C infection: rs1710, P = 0.0452). Our results suggest both spontaneous HBsAg seroclearance and serodecline are modified by the interaction between HLA variants and HBV genotype." @default.
• W4313703383 created "2023-01-08" @default.
• W4313703383 creator A5000164895 @default.
• W4313703383 creator A5001321493 @default.
• W4313703383 creator A5001718162 @default.
• W4313703383 creator A5017819098 @default.
• W4313703383 creator A5035627161 @default.
• W4313703383 creator A5044107230 @default.
• W4313703383 creator A5044999738 @default.
• W4313703383 creator A5059993079 @default.
• W4313703383 creator A5091425276 @default.
• W4313703383 date "2023-01-07" @default.
• W4313703383 modified "2023-09-26" @default.
• W4313703383 title "HBV genotype-dependent association of HLA variants with the serodecline of HBsAg in chronic hepatitis B patients" @default.
• W4313703383 cites W1906881483 @default.
• W4313703383 cites W1968503956 @default.
• W4313703383 cites W1971928077 @default.
• W4313703383 cites W1975944134 @default.
• W4313703383 cites W1978385313 @default.
• W4313703383 cites W1996594959 @default.
• W4313703383 cites W1997994653 @default.
• W4313703383 cites W1999341037 @default.
• W4313703383 cites W2006256967 @default.
• W4313703383 cites W2011736290 @default.
• W4313703383 cites W2012824806 @default.
• W4313703383 cites W2015500358 @default.
• W4313703383 cites W2023906991 @default.
• W4313703383 cites W2026020529 @default.
• W4313703383 cites W2046814534 @default.
• W4313703383 cites W2048239668 @default.
• W4313703383 cites W2058955194 @default.
• W4313703383 cites W2066639195 @default.
• W4313703383 cites W2067720485 @default.
• W4313703383 cites W2079963629 @default.
• W4313703383 cites W2080150779 @default.
• W4313703383 cites W2088140119 @default.
• W4313703383 cites W2091692996 @default.
• W4313703383 cites W2104389844 @default.
• W4313703383 cites W2125710787 @default.
• W4313703383 cites W2130726794 @default.
• W4313703383 cites W2346273155 @default.
• W4313703383 cites W2516779495 @default.
• W4313703383 cites W2612738919 @default.
• W4313703383 cites W2738748857 @default.
• W4313703383 cites W2887201969 @default.
• W4313703383 cites W2896802137 @default.
• W4313703383 cites W3090496870 @default.
• W4313703383 cites W4225344778 @default.
• W4313703383 doi "https://doi.org/10.1038/s41598-023-27570-y" @default.
• W4313703383 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36611047" @default.
• W4313703383 hasPublicationYear "2023" @default.
• W4313703383 type Work @default.
• W4313703383 citedByCount "0" @default.
• W4313703383 crossrefType "journal-article" @default.
• W4313703383 hasAuthorship W4313703383A5000164895 @default.
• W4313703383 hasAuthorship W4313703383A5001321493 @default.
• W4313703383 hasAuthorship W4313703383A5001718162 @default.
• W4313703383 hasAuthorship W4313703383A5017819098 @default.
• W4313703383 hasAuthorship W4313703383A5035627161 @default.
• W4313703383 hasAuthorship W4313703383A5044107230 @default.
• W4313703383 hasAuthorship W4313703383A5044999738 @default.
• W4313703383 hasAuthorship W4313703383A5059993079 @default.
• W4313703383 hasAuthorship W4313703383A5091425276 @default.
• W4313703383 hasBestOaLocation W43137033831 @default.
• W4313703383 hasConcept C104317684 @default.
• W4313703383 hasConcept C135763542 @default.
• W4313703383 hasConcept C159047783 @default.
• W4313703383 hasConcept C180754005 @default.
• W4313703383 hasConcept C203014093 @default.
• W4313703383 hasConcept C2522874641 @default.
• W4313703383 hasConcept C2775940106 @default.
• W4313703383 hasConcept C2777382497 @default.
• W4313703383 hasConcept C2777410769 @default.
• W4313703383 hasConcept C2780593183 @default.
• W4313703383 hasConcept C54355233 @default.
• W4313703383 hasConcept C71924100 @default.
• W4313703383 hasConcept C86803240 @default.
• W4313703383 hasConceptScore W4313703383C104317684 @default.
• W4313703383 hasConceptScore W4313703383C135763542 @default.
• W4313703383 hasConceptScore W4313703383C159047783 @default.
• W4313703383 hasConceptScore W4313703383C180754005 @default.
• W4313703383 hasConceptScore W4313703383C203014093 @default.
• W4313703383 hasConceptScore W4313703383C2522874641 @default.
• W4313703383 hasConceptScore W4313703383C2775940106 @default.
• W4313703383 hasConceptScore W4313703383C2777382497 @default.
• W4313703383 hasConceptScore W4313703383C2777410769 @default.
• W4313703383 hasConceptScore W4313703383C2780593183 @default.
• W4313703383 hasConceptScore W4313703383C54355233 @default.
• W4313703383 hasConceptScore W4313703383C71924100 @default.
• W4313703383 hasConceptScore W4313703383C86803240 @default.
• W4313703383 hasFunder F4320321041 @default.
• W4313703383 hasFunder F4320322795 @default.
• W4313703383 hasIssue "1" @default.
• W4313703383 hasLocation W43137033831 @default.
• W4313703383 hasLocation W43137033832 @default.
• W4313703383 hasLocation W43137033833 @default.
• W4313703383 hasOpenAccess W4313703383 @default.
• W4313703383 hasPrimaryLocation W43137033831 @default.
• W4313703383 hasRelatedWork W2037843958 @default.
• W4313703383 hasRelatedWork W2049261331 @default.

• next