Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313703402> ?p ?o ?g. }
- W4313703402 abstract "Abstract NEK9 is a key player in the NEK9–EG5 axis for microtubule polymerization, chromosome alignment, and mitosis. In present study, we investigated the altered expression of the NEK9, EG5 and acetyl-α-tubulin as well as common epithelial–mesenchymal transition (EMT) markers (E-cadherin, vimentin, claudin-1, and β-catenin) through the immunohistochemistry analysis of 138 patients with pathologic T3 (pT3) stage colon cancers, and evaluated their metastatic potential. NEK9 expression showed an association with distant metastasis ( P = 0.032) and was an independent predictive factor for distant metastasis (HR = 3.365, P < 0.001) by multivariate analysis, which was more significant than either the regional nodal metastasis (HR = 2.496, P = 0.007) or lymphovascular invasion (HR = 2.090, P = 0.153). Positive correlations were observed between NEK9 and EG5 or acetyl-α-tubulin (r = 0.236 and P = 0.007; r = 0.181 and P = 0.038, respectively) and concordant overexpression of the NEK9–EG5 axis was further confirmed in colon cancer cell lines. These findings collectively suggest that the overexpression of the NEK9–EG5 axis is present and associated with distant metastasis in colon cancer. These biomarkers might be useful for predicting metastatic potential among the patients with pT3 colon cancers." @default.
- W4313703402 created "2023-01-08" @default.
- W4313703402 creator A5028940266 @default.
- W4313703402 creator A5030999088 @default.
- W4313703402 creator A5044079996 @default.
- W4313703402 creator A5077579583 @default.
- W4313703402 creator A5080825197 @default.
- W4313703402 creator A5082872490 @default.
- W4313703402 date "2023-01-07" @default.
- W4313703402 modified "2023-10-14" @default.
- W4313703402 title "Overexpression of the NEK9–EG5 axis is a novel metastatic marker in pathologic stage T3 colon cancer" @default.
- W4313703402 cites W1901442544 @default.
- W4313703402 cites W1954576322 @default.
- W4313703402 cites W1984457233 @default.
- W4313703402 cites W1987298366 @default.
- W4313703402 cites W1990219149 @default.
- W4313703402 cites W1999722591 @default.
- W4313703402 cites W2012966977 @default.
- W4313703402 cites W2014038256 @default.
- W4313703402 cites W2057400222 @default.
- W4313703402 cites W2058481603 @default.
- W4313703402 cites W2062072171 @default.
- W4313703402 cites W2072853614 @default.
- W4313703402 cites W2089185363 @default.
- W4313703402 cites W2114865203 @default.
- W4313703402 cites W2118639465 @default.
- W4313703402 cites W2126718734 @default.
- W4313703402 cites W2141295772 @default.
- W4313703402 cites W2145052109 @default.
- W4313703402 cites W2146314877 @default.
- W4313703402 cites W2154589460 @default.
- W4313703402 cites W2177036962 @default.
- W4313703402 cites W2470172036 @default.
- W4313703402 cites W2482244137 @default.
- W4313703402 cites W2558137541 @default.
- W4313703402 cites W2775650492 @default.
- W4313703402 cites W2777334852 @default.
- W4313703402 cites W2923287877 @default.
- W4313703402 cites W3008811734 @default.
- W4313703402 cites W3011331060 @default.
- W4313703402 cites W3040154381 @default.
- W4313703402 cites W3111834837 @default.
- W4313703402 cites W3128615672 @default.
- W4313703402 cites W3162051627 @default.
- W4313703402 cites W3163086876 @default.
- W4313703402 cites W3180228293 @default.
- W4313703402 cites W393883301 @default.
- W4313703402 cites W4200525701 @default.
- W4313703402 doi "https://doi.org/10.1038/s41598-022-26249-0" @default.
- W4313703402 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36611072" @default.
- W4313703402 hasPublicationYear "2023" @default.
- W4313703402 type Work @default.
- W4313703402 citedByCount "0" @default.
- W4313703402 crossrefType "journal-article" @default.
- W4313703402 hasAuthorship W4313703402A5028940266 @default.
- W4313703402 hasAuthorship W4313703402A5030999088 @default.
- W4313703402 hasAuthorship W4313703402A5044079996 @default.
- W4313703402 hasAuthorship W4313703402A5077579583 @default.
- W4313703402 hasAuthorship W4313703402A5080825197 @default.
- W4313703402 hasAuthorship W4313703402A5082872490 @default.
- W4313703402 hasBestOaLocation W43137034021 @default.
- W4313703402 hasConcept C121608353 @default.
- W4313703402 hasConcept C126322002 @default.
- W4313703402 hasConcept C142724271 @default.
- W4313703402 hasConcept C143998085 @default.
- W4313703402 hasConcept C146357865 @default.
- W4313703402 hasConcept C147447768 @default.
- W4313703402 hasConcept C151730666 @default.
- W4313703402 hasConcept C204232928 @default.
- W4313703402 hasConcept C2778740770 @default.
- W4313703402 hasConcept C2779013556 @default.
- W4313703402 hasConcept C502942594 @default.
- W4313703402 hasConcept C526805850 @default.
- W4313703402 hasConcept C71924100 @default.
- W4313703402 hasConcept C76419328 @default.
- W4313703402 hasConcept C86803240 @default.
- W4313703402 hasConceptScore W4313703402C121608353 @default.
- W4313703402 hasConceptScore W4313703402C126322002 @default.
- W4313703402 hasConceptScore W4313703402C142724271 @default.
- W4313703402 hasConceptScore W4313703402C143998085 @default.
- W4313703402 hasConceptScore W4313703402C146357865 @default.
- W4313703402 hasConceptScore W4313703402C147447768 @default.
- W4313703402 hasConceptScore W4313703402C151730666 @default.
- W4313703402 hasConceptScore W4313703402C204232928 @default.
- W4313703402 hasConceptScore W4313703402C2778740770 @default.
- W4313703402 hasConceptScore W4313703402C2779013556 @default.
- W4313703402 hasConceptScore W4313703402C502942594 @default.
- W4313703402 hasConceptScore W4313703402C526805850 @default.
- W4313703402 hasConceptScore W4313703402C71924100 @default.
- W4313703402 hasConceptScore W4313703402C76419328 @default.
- W4313703402 hasConceptScore W4313703402C86803240 @default.
- W4313703402 hasIssue "1" @default.
- W4313703402 hasLocation W43137034021 @default.
- W4313703402 hasLocation W43137034022 @default.
- W4313703402 hasLocation W43137034023 @default.
- W4313703402 hasOpenAccess W4313703402 @default.
- W4313703402 hasPrimaryLocation W43137034021 @default.
- W4313703402 hasRelatedWork W2085060133 @default.
- W4313703402 hasRelatedWork W2143455778 @default.
- W4313703402 hasRelatedWork W2176631918 @default.