Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313703730> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W4313703730 abstract "Trial-level surrogates are useful tools for improving the speed and cost effectiveness of trials but surrogates that have not been properly evaluated can cause misleading results. The evaluation procedure is often contextual and depends on the type of trial setting. There have been many proposed methods for trial-level surrogate evaluation, but none, to our knowledge, for the specific setting of platform studies. As platform studies are becoming more popular, methods for surrogate evaluation using them are needed. These studies also offer a rich data resource for surrogate evaluation that would not normally be possible. However, they also offer a set of statistical issues including heterogeneity of the study population, treatments, implementation, and even potentially the quality of the surrogate. We propose the use of a hierarchical Bayesian semiparametric model for the evaluation of potential surrogates using nonparametric priors for the distribution of true effects based on Dirichlet process mixtures. The motivation for this approach is to flexibly model relationships between the treatment effect on the surrogate and the treatment effect on the outcome and also to identify potential clusters with differential surrogate value in a data-driven manner so that treatment effects on the surrogate can be used to reliably predict treatment effects on the clinical outcome. In simulations, we find that our proposed method is superior to a simple, but fairly standard, hierarchical Bayesian method. We demonstrate how our method can be used in a simulated illustrative example (based on the ProBio trial), in which we are able to identify clusters where the surrogate is, and is not useful. We plan to apply our method to the ProBio trial, once it is completed." @default.
- W4313703730 created "2023-01-08" @default.
- W4313703730 creator A5002455613 @default.
- W4313703730 creator A5025037358 @default.
- W4313703730 creator A5031529176 @default.
- W4313703730 creator A5091431698 @default.
- W4313703730 date "2023-01-04" @default.
- W4313703730 modified "2023-10-01" @default.
- W4313703730 title "Flexible evaluation of surrogacy in platform studies" @default.
- W4313703730 cites W1596460436 @default.
- W4313703730 cites W1964458952 @default.
- W4313703730 cites W2064912673 @default.
- W4313703730 cites W2068869745 @default.
- W4313703730 cites W2084935411 @default.
- W4313703730 cites W2107085109 @default.
- W4313703730 cites W2108464948 @default.
- W4313703730 cites W2111408254 @default.
- W4313703730 cites W2126133903 @default.
- W4313703730 cites W2136999619 @default.
- W4313703730 cites W2148689451 @default.
- W4313703730 cites W2158266063 @default.
- W4313703730 cites W2240262094 @default.
- W4313703730 cites W2896276870 @default.
- W4313703730 cites W2909626878 @default.
- W4313703730 cites W3004002562 @default.
- W4313703730 cites W3037898837 @default.
- W4313703730 cites W3040508995 @default.
- W4313703730 cites W4220956861 @default.
- W4313703730 cites W4255319250 @default.
- W4313703730 cites W92430206 @default.
- W4313703730 doi "https://doi.org/10.1093/biostatistics/kxac053" @default.
- W4313703730 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36610075" @default.
- W4313703730 hasPublicationYear "2023" @default.
- W4313703730 type Work @default.
- W4313703730 citedByCount "0" @default.
- W4313703730 crossrefType "journal-article" @default.
- W4313703730 hasAuthorship W4313703730A5002455613 @default.
- W4313703730 hasAuthorship W4313703730A5025037358 @default.
- W4313703730 hasAuthorship W4313703730A5031529176 @default.
- W4313703730 hasAuthorship W4313703730A5091431698 @default.
- W4313703730 hasConcept C102366305 @default.
- W4313703730 hasConcept C105795698 @default.
- W4313703730 hasConcept C107673813 @default.
- W4313703730 hasConcept C117251300 @default.
- W4313703730 hasConcept C119857082 @default.
- W4313703730 hasConcept C124101348 @default.
- W4313703730 hasConcept C131675550 @default.
- W4313703730 hasConcept C144237770 @default.
- W4313703730 hasConcept C148220186 @default.
- W4313703730 hasConcept C149782125 @default.
- W4313703730 hasConcept C154945302 @default.
- W4313703730 hasConcept C177264268 @default.
- W4313703730 hasConcept C177769412 @default.
- W4313703730 hasConcept C199360897 @default.
- W4313703730 hasConcept C2908647359 @default.
- W4313703730 hasConcept C33923547 @default.
- W4313703730 hasConcept C41008148 @default.
- W4313703730 hasConcept C71924100 @default.
- W4313703730 hasConcept C99454951 @default.
- W4313703730 hasConceptScore W4313703730C102366305 @default.
- W4313703730 hasConceptScore W4313703730C105795698 @default.
- W4313703730 hasConceptScore W4313703730C107673813 @default.
- W4313703730 hasConceptScore W4313703730C117251300 @default.
- W4313703730 hasConceptScore W4313703730C119857082 @default.
- W4313703730 hasConceptScore W4313703730C124101348 @default.
- W4313703730 hasConceptScore W4313703730C131675550 @default.
- W4313703730 hasConceptScore W4313703730C144237770 @default.
- W4313703730 hasConceptScore W4313703730C148220186 @default.
- W4313703730 hasConceptScore W4313703730C149782125 @default.
- W4313703730 hasConceptScore W4313703730C154945302 @default.
- W4313703730 hasConceptScore W4313703730C177264268 @default.
- W4313703730 hasConceptScore W4313703730C177769412 @default.
- W4313703730 hasConceptScore W4313703730C199360897 @default.
- W4313703730 hasConceptScore W4313703730C2908647359 @default.
- W4313703730 hasConceptScore W4313703730C33923547 @default.
- W4313703730 hasConceptScore W4313703730C41008148 @default.
- W4313703730 hasConceptScore W4313703730C71924100 @default.
- W4313703730 hasConceptScore W4313703730C99454951 @default.
- W4313703730 hasFunder F4320322581 @default.
- W4313703730 hasFunder F4320332161 @default.
- W4313703730 hasLocation W43137037301 @default.
- W4313703730 hasLocation W43137037302 @default.
- W4313703730 hasOpenAccess W4313703730 @default.
- W4313703730 hasPrimaryLocation W43137037301 @default.
- W4313703730 hasRelatedWork W1978671944 @default.
- W4313703730 hasRelatedWork W1982995393 @default.
- W4313703730 hasRelatedWork W2012808290 @default.
- W4313703730 hasRelatedWork W2026549442 @default.
- W4313703730 hasRelatedWork W2053923183 @default.
- W4313703730 hasRelatedWork W2061674822 @default.
- W4313703730 hasRelatedWork W2735260132 @default.
- W4313703730 hasRelatedWork W4299362704 @default.
- W4313703730 hasRelatedWork W1995955285 @default.
- W4313703730 hasRelatedWork W2118541299 @default.
- W4313703730 isParatext "false" @default.
- W4313703730 isRetracted "false" @default.
- W4313703730 workType "article" @default.