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• W4313703744 endingPage "419" @default.
• W4313703744 startingPage "396" @default.
• W4313703744 abstract "Trypanosoma brucei belongs to a group of protozoans presenting fragmented large subunit rRNA. Its LSU rRNA equivalent to the 25S/28S rRNA of other eukaryotes is split into six fragments, requiring additional processing for removal of the extra spacer sequences. We have used a genetic complementation strategy to further investigate the T. brucei RRP44 nuclease in pre-rRNA maturation. TbRRP44 contains both a PIN and a RNB domain whose homologues are found in association with the exosome complex. We found that the exonucleolytic activity of the RNB domain as well as the physical presence of the PIN domain are essential for TbRRP44 function, while a catalytic site mutation in the PIN domain has no detectable effect on cell growth. A new endonucleolytic cleavage site in ITS1 was identified. In addition to the 5.8S rRNA 3'-end maturation, TbRRP44 is required for degradation of the excised 5'-ETS and for removal of part of ITS1 during maturation of the 18S rRNA 3'-end. TbRRP44 deficiency leads to accumulation of many LSU intermediate precursors, most of them not detected in control cells. TbRRP44 is also required for U3 snoRNA and spliced leader processing, indicating that TbRRP44 may have a wide role in RNA processing in T. brucei." @default.
• W4313703744 created "2023-01-08" @default.
• W4313703744 creator A5040462632 @default.
• W4313703744 creator A5051484755 @default.
• W4313703744 creator A5061308652 @default.
• W4313703744 creator A5074172780 @default.
• W4313703744 date "2023-01-05" @default.
• W4313703744 modified "2023-10-09" @default.
• W4313703744 title "Dissecting <i>Trypanosoma brucei</i> RRP44 function in the maturation of segmented ribosomal RNA using a regulated genetic complementation system" @default.
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