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- W4313704259 abstract "<h2>Abstract</h2> Lobular carcinoma in situ (LCIS) is a non-invasive proliferation of discohesive cells arising in the terminal duct lobular unit. LCIS was initially described as a marker of bilateral increased risk of invasive breast carcinoma, however more recently it is recognized to act as a non-obligate precursor of invasive lobular carcinoma. There are 3 main types of LCIS; classical LCIS, florid LCIS and pleomorphic LCIS. The morphological characteristics of the 3 subtypes are described, along with differences in tumour biology. LCIS is associated with loss of expression of E-cadherin protein, part of the cadherin:catenin cell adhesion complex. Immunohistochemistry for E-cadherin can assist in the diagnosis of LCIS, but important caveats apply in its interpretation and other markers such as beta catenin and p120 may also be of use. Classical LCIS has a low upgrade rate and recommended management is regular follow up, however pleomorphic and florid LCIS have a higher risk of associated invasive cancer and are managed like DCIS with therapeutic excision aiming for clear margins." @default.
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- W4313704259 date "2023-03-01" @default.
- W4313704259 modified "2023-09-27" @default.
- W4313704259 title "The diagnosis and management of lobular carcinoma in situ" @default.
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- W4313704259 doi "https://doi.org/10.1016/j.mpdhp.2022.12.004" @default.
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