Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313704270> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W4313704270 abstract "Abstract Introduction Colorectal cancer (CRC) is the third leading cause of death from cancer in the world; early detection is a key factor for patient´s prognosis. Microvesicles (MVs) are subcellular structures delimited by lipid bilayer intimately involved in physio-pathological processes such as cancer. Our objective is the characterization and detection of surface proteins in plasma derived MVs, as well as their usefulness as a tool in the detection of CRC. Methods Circulating MVs in peripheral blood of healthy individuals, with adenomas, high grade adenoma or carcinoma were isolated and characterized. MVs CD9, CD147 and EpCaM MVs surface proteins quantification was performed using an innovative lateral flow immunoassay (LFIA) developed in our laboratory. Results The characterization of the plasma MVs confirmed our previous observations, presenting a lower concentration of MVs in the groups of high-grade adenoma and mainly CRC. However, the carcinoma group presents a higher amount of protein per MV suggesting a greater MV´s complexity in this group. The analysis of surface antigens by LFIA show an unexpectedly significant reduction of these proteins in the carcinoma group. Conclusions The detection of antigens on the surface of MVs by LFIA may be able to discriminate patients with CRC and could emerge as an alternative test that complements CRC screening programs." @default.
- W4313704270 created "2023-01-08" @default.
- W4313704270 creator A5002765089 @default.
- W4313704270 creator A5006345028 @default.
- W4313704270 creator A5036073182 @default.
- W4313704270 creator A5074733192 @default.
- W4313704270 creator A5082091400 @default.
- W4313704270 creator A5082783173 @default.
- W4313704270 creator A5084518382 @default.
- W4313704270 creator A5086716594 @default.
- W4313704270 date "2023-01-04" @default.
- W4313704270 modified "2023-09-27" @default.
- W4313704270 title "MICROVESICLE SURFACE PROTEIN DETECTION AS A POTENTIAL BIOMARKER IN COLORECTAL CANCER" @default.
- W4313704270 doi "https://doi.org/10.1093/bjs/znac443.051" @default.
- W4313704270 hasPublicationYear "2023" @default.
- W4313704270 type Work @default.
- W4313704270 citedByCount "0" @default.
- W4313704270 crossrefType "journal-article" @default.
- W4313704270 hasAuthorship W4313704270A5002765089 @default.
- W4313704270 hasAuthorship W4313704270A5006345028 @default.
- W4313704270 hasAuthorship W4313704270A5036073182 @default.
- W4313704270 hasAuthorship W4313704270A5074733192 @default.
- W4313704270 hasAuthorship W4313704270A5082091400 @default.
- W4313704270 hasAuthorship W4313704270A5082783173 @default.
- W4313704270 hasAuthorship W4313704270A5084518382 @default.
- W4313704270 hasAuthorship W4313704270A5086716594 @default.
- W4313704270 hasBestOaLocation W43137042701 @default.
- W4313704270 hasConcept C104317684 @default.
- W4313704270 hasConcept C121608353 @default.
- W4313704270 hasConcept C126322002 @default.
- W4313704270 hasConcept C142724271 @default.
- W4313704270 hasConcept C143998085 @default.
- W4313704270 hasConcept C145059251 @default.
- W4313704270 hasConcept C147483822 @default.
- W4313704270 hasConcept C203014093 @default.
- W4313704270 hasConcept C20518536 @default.
- W4313704270 hasConcept C207886595 @default.
- W4313704270 hasConcept C2777428134 @default.
- W4313704270 hasConcept C2781197716 @default.
- W4313704270 hasConcept C2909763251 @default.
- W4313704270 hasConcept C502942594 @default.
- W4313704270 hasConcept C526805850 @default.
- W4313704270 hasConcept C55493867 @default.
- W4313704270 hasConcept C71924100 @default.
- W4313704270 hasConcept C86803240 @default.
- W4313704270 hasConceptScore W4313704270C104317684 @default.
- W4313704270 hasConceptScore W4313704270C121608353 @default.
- W4313704270 hasConceptScore W4313704270C126322002 @default.
- W4313704270 hasConceptScore W4313704270C142724271 @default.
- W4313704270 hasConceptScore W4313704270C143998085 @default.
- W4313704270 hasConceptScore W4313704270C145059251 @default.
- W4313704270 hasConceptScore W4313704270C147483822 @default.
- W4313704270 hasConceptScore W4313704270C203014093 @default.
- W4313704270 hasConceptScore W4313704270C20518536 @default.
- W4313704270 hasConceptScore W4313704270C207886595 @default.
- W4313704270 hasConceptScore W4313704270C2777428134 @default.
- W4313704270 hasConceptScore W4313704270C2781197716 @default.
- W4313704270 hasConceptScore W4313704270C2909763251 @default.
- W4313704270 hasConceptScore W4313704270C502942594 @default.
- W4313704270 hasConceptScore W4313704270C526805850 @default.
- W4313704270 hasConceptScore W4313704270C55493867 @default.
- W4313704270 hasConceptScore W4313704270C71924100 @default.
- W4313704270 hasConceptScore W4313704270C86803240 @default.
- W4313704270 hasIssue "Supplement_1" @default.
- W4313704270 hasLocation W43137042701 @default.
- W4313704270 hasOpenAccess W4313704270 @default.
- W4313704270 hasPrimaryLocation W43137042701 @default.
- W4313704270 hasRelatedWork W2003356793 @default.
- W4313704270 hasRelatedWork W2026856965 @default.
- W4313704270 hasRelatedWork W2041926192 @default.
- W4313704270 hasRelatedWork W2072537511 @default.
- W4313704270 hasRelatedWork W2519566343 @default.
- W4313704270 hasRelatedWork W2965269027 @default.
- W4313704270 hasRelatedWork W3039364812 @default.
- W4313704270 hasRelatedWork W3120235892 @default.
- W4313704270 hasRelatedWork W3149210900 @default.
- W4313704270 hasRelatedWork W4380368510 @default.
- W4313704270 hasVolume "110" @default.
- W4313704270 isParatext "false" @default.
- W4313704270 isRetracted "false" @default.
- W4313704270 workType "article" @default.