Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313704760> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W4313704760 endingPage "97" @default.
- W4313704760 startingPage "92" @default.
- W4313704760 abstract "A common approach in laboratory medicine is to use a simple but sensitive test to screen samples to identify those that require additional investigation with a more complex and informative method. Selection of screening thresholds can be guided by biomarker distribution in the tested population and the analytical imprecision of the method.A simulation using joint probabilities derived from the population distribution for galactose-1-phosphate uridylyltransferase (GALT) activity and the analytical imprecision for the GALT assay was used to estimate the number of samples that would require repeat analysis and the number of samples with possibly false-negative screening determinations due to analytical imprecision.In the case of GALT activity, screening a conservative initial threshold 6 standard deviations from the confirmation threshold can essentially eliminate the chance of a false-negative screening determination due to analytical imprecision. The trade-off is a greater number of samples requiring follow-up testing (n = 222, equivalent to 0.15% of samples annually).Selection of thresholds in a screening algorithm is informed by estimates of the number of samples that would require repeat testing and the number that could be false negative due to analytical imprecision." @default.
- W4313704760 created "2023-01-08" @default.
- W4313704760 creator A5007084476 @default.
- W4313704760 creator A5089748758 @default.
- W4313704760 date "2023-01-04" @default.
- W4313704760 modified "2023-10-16" @default.
- W4313704760 title "An Approach for Evaluating Potential Screening Thresholds Using Biomarker Population Distribution and Analytical Imprecision" @default.
- W4313704760 cites W111645394 @default.
- W4313704760 cites W1879090356 @default.
- W4313704760 cites W2006183318 @default.
- W4313704760 cites W2008770239 @default.
- W4313704760 cites W2066854085 @default.
- W4313704760 cites W2079332579 @default.
- W4313704760 cites W2139436361 @default.
- W4313704760 cites W2990427812 @default.
- W4313704760 doi "https://doi.org/10.1093/jalm/jfac102" @default.
- W4313704760 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36610417" @default.
- W4313704760 hasPublicationYear "2023" @default.
- W4313704760 type Work @default.
- W4313704760 citedByCount "0" @default.
- W4313704760 crossrefType "journal-article" @default.
- W4313704760 hasAuthorship W4313704760A5007084476 @default.
- W4313704760 hasAuthorship W4313704760A5089748758 @default.
- W4313704760 hasBestOaLocation W43137047601 @default.
- W4313704760 hasConcept C105795698 @default.
- W4313704760 hasConcept C154945302 @default.
- W4313704760 hasConcept C2781197716 @default.
- W4313704760 hasConcept C2908647359 @default.
- W4313704760 hasConcept C33923547 @default.
- W4313704760 hasConcept C41008148 @default.
- W4313704760 hasConcept C55493867 @default.
- W4313704760 hasConcept C71924100 @default.
- W4313704760 hasConcept C81917197 @default.
- W4313704760 hasConcept C86803240 @default.
- W4313704760 hasConcept C99454951 @default.
- W4313704760 hasConceptScore W4313704760C105795698 @default.
- W4313704760 hasConceptScore W4313704760C154945302 @default.
- W4313704760 hasConceptScore W4313704760C2781197716 @default.
- W4313704760 hasConceptScore W4313704760C2908647359 @default.
- W4313704760 hasConceptScore W4313704760C33923547 @default.
- W4313704760 hasConceptScore W4313704760C41008148 @default.
- W4313704760 hasConceptScore W4313704760C55493867 @default.
- W4313704760 hasConceptScore W4313704760C71924100 @default.
- W4313704760 hasConceptScore W4313704760C81917197 @default.
- W4313704760 hasConceptScore W4313704760C86803240 @default.
- W4313704760 hasConceptScore W4313704760C99454951 @default.
- W4313704760 hasIssue "1" @default.
- W4313704760 hasLocation W43137047601 @default.
- W4313704760 hasLocation W43137047602 @default.
- W4313704760 hasOpenAccess W4313704760 @default.
- W4313704760 hasPrimaryLocation W43137047601 @default.
- W4313704760 hasRelatedWork W2083542484 @default.
- W4313704760 hasRelatedWork W2119158312 @default.
- W4313704760 hasRelatedWork W2125356288 @default.
- W4313704760 hasRelatedWork W2128302072 @default.
- W4313704760 hasRelatedWork W2330407128 @default.
- W4313704760 hasRelatedWork W2552050053 @default.
- W4313704760 hasRelatedWork W2606073172 @default.
- W4313704760 hasRelatedWork W2969635709 @default.
- W4313704760 hasRelatedWork W2970622411 @default.
- W4313704760 hasRelatedWork W2751504412 @default.
- W4313704760 hasVolume "8" @default.
- W4313704760 isParatext "false" @default.
- W4313704760 isRetracted "false" @default.
- W4313704760 workType "article" @default.